| 1. |
- Robinson, N. A., et al.
(författare)
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Applying genetic technologies to combat infectious diseases in aquaculture
- 2022
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Ingår i: Reviews in Aquaculture. - : Wiley. - 1753-5123 .- 1753-5131. ; 15:2, s. 491-535
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Tidskriftsartikel (refereegranskat)abstract
- Disease and parasitism cause major welfare, environmental and economic concerns for global aquaculture. In this review, we examine the status and potential of technologies that exploit genetic variation in host resistance to tackle this problem. We argue that there is an urgent need to improve understanding of the genetic mechanisms involved, leading to the development of tools that can be applied to boost host resistance and reduce the disease burden. We draw on two pressing global disease problems as case studies—sea lice infestations in salmonids and white spot syndrome in shrimp. We review how the latest genetic technologies can be capitalised upon to determine the mechanisms underlying inter- and intra-species variation in pathogen/parasite resistance, and how the derived knowledge could be applied to boost disease resistance using selective breeding, gene editing and/or with targeted feed treatments and vaccines. Gene editing brings novel opportunities, but also implementation and dissemination challenges, and necessitates new protocols to integrate the technology into aquaculture breeding programmes. There is also an ongoing need to minimise risks of disease agents evolving to overcome genetic improvements to host resistance, and insights from epidemiological and evolutionary models of pathogen infestation in wild and cultured host populations are explored. Ethical issues around the different approaches for achieving genetic resistance are discussed. Application of genetic technologies and approaches has potential to improve fundamental knowledge of mechanisms affecting genetic resistance and provide effective pathways for implementation that could lead to more resistant aquaculture stocks, transforming global aquaculture. © 2022 The Authors. Reviews in Aquaculture published by John Wiley & Sons Australia, Ltd.
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| 2. |
- Kalenyuk, Aleksey A., et al.
(författare)
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Unusual two-dimensional behavior of iron-based superconductors with low anisotropy
- 2017
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Ingår i: Physical Review B. - 2469-9950 .- 2469-9969. ; 96:13
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Tidskriftsartikel (refereegranskat)abstract
- We study angular-dependent magnetoresistance in iron-based superconductors Ba1−xNaxFe2As2 and FeTe1−xSex. Both superconductors have relatively small anisotropies γ∼2 and exhibit a three-dimensional (3D) behavior at low temperatures. However, we observe that they start to exhibit a profound two-dimensional behavior at elevated temperatures and in applied magnetic field parallel to the surface. We conclude that the unexpected two-dimensional (2D) behavior of the studied low-anisotropic superconductors is not related to layeredness of the materials, but is caused by appearance of surface superconductivity when magnetic field exceeds the upper critical field Hc2(T) for destruction of bulk superconductivity. We argue that the corresponding 3D-2D bulk-to-surface dimensional transition can be used for accurate determination of the upper critical field.
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| 5. |
- Galin, Mikhail A., et al.
(författare)
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Synchronization of Large Josephson-Junction Arrays by Traveling Electromagnetic Waves
- 2018
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Ingår i: Physical Review Applied. - 2331-7019. ; 9:5
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Tidskriftsartikel (refereegranskat)abstract
- Mutual synchronization of many Josephson junctions is required for superradiant enhancement of the emission power. However, the larger the junction array is, the more difficult is the synchronization, especially when the array size becomes much larger than the emitted wavelength. Here, we study experimentally Josephson emission from such larger-than-the-wavelength Nb/NbSi/Nb junction arrays. For one of the arrays we observe a clear superradiant enhancement of emission above a threshold number of active junctions. The arrays exhibit strong geometrical resonances, seen as steps in current-voltage characteristics. However, radiation patterns of the arrays have forward-backward asymmetry, which is inconsistent with the solely geometrical resonance (standing-wave) mechanism of synchronization. We argue that the asymmetry provides evidence for an alternative mechanism of synchronization mediated by unidirectional traveling-wave propagation along the array (such as a surface plasmon). In this case, emission occurs predominantly in the direction of propagation of the traveling wave. Our conclusions are supported by numerical modeling of Josephson traveling-wave antenna. We argue that such a nonresonant mechanism of synchronization opens a possibility for phase locking of very large arrays of oscillators.
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| 6. |
- Kalenyuk, Aleksey A., et al.
(författare)
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Influence of the Fermi surface geometry on the Josephson effect between iron-pnictide and conventional superconductors
- 2021
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Ingår i: Physical Review B. - 2469-9950 .- 2469-9969. ; 103:21
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Tidskriftsartikel (refereegranskat)abstract
- We study hybrid Josephson junctions between a multiband Ba1-xNaxFe2As2 iron-pnictide and Nb. We observe that the insertion of a Cu interlayer in such junctions leads to a dramatic enhancement of the IcRn product, despite the weaker proximity-induced superconductivity of Cu. This counterintuitive phenomenon is attributed to the differences in Fermi surface geometries of Nb and Cu, which affect the selectivity of tunneling in sign-reversal s± bands of pnictide. Our results indicate that the sensitivity to Fermi surface geometries provides a new tool for phase-sensitive studies and paves the way to conscious Fermi surface engineering of pnictide junctions.
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| 7. |
- Kalenyuk, Aleksey A., et al.
(författare)
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Phase-Sensitive Evidence for the Sign-Reversal s± Symmetry of the Order Parameter in an Iron-Pnictide Superconductor Using Nb/Ba1−xNaxFe2As2 Josephson Junctions
- 2018
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 120:6
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Tidskriftsartikel (refereegranskat)abstract
- Josephson current provides a phase-sensitive tool for probing the pairing symmetry. Here we present an experimental study of high-quality Josephson junctions between a conventional s-wave superconductor Nb and a multiband iron-pnictide Ba1−xNaxFe2As2. Junctions exhibit a large enough critical current density to preclude the d-wave symmetry of the order parameter in the pnictide. However, the IcRn product is very small ≃3μV, which is not consistent with the sign-preserving s++ symmetry either. We argue that the small IcRn value, along with its unusual temperature dependence, provides evidence for the sign-reversal s± symmetry of the order parameter in Ba1−xNaxFe2As2. We conclude that it is the phase sensitivity of our junctions that leads to an almost complete (below a subpercent) cancellation of supercurrents from sign-reversal bands in the pnictide.
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| 9. |
- Dmitriev, Alexey A, et al.
(författare)
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Genetic and epigenetic analysis of non-small cell lung cancer with NotI-microarrays
- 2012
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Ingår i: Epigenetics. - : Landes Bioscience. - 1559-2294 .- 1559-2308. ; 7:5, s. 502-513
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Tidskriftsartikel (refereegranskat)abstract
- This study aimed to clarify genetic and epigenetic alterations that occur during lung carcinogenesis and to design perspective sets of newly identified biomarkers. The original method includes chromosome 3 specific NotI-microarrays containing 180 NotI clones associated with genes for hybridization with 40 paired normal/tumor DNA samples of primary lung tumors: 28 squamous cell carcinomas (SCC) and 12 adenocarcinomas (ADC). The NotI-microarray data were confirmed by qPCR and bisulfite sequencing analyses. Forty-four genes showed methylation and/or deletions in more than 15% of non-small cell lung cancer (NSCLC) samples. In general, SCC samples were more frequently methylated/deleted than ADC. Moreover, the SCC alterations were observed already at stage I of tumor development, whereas in ADC many genes showed tumor progression specific methylation/deletions. Among genes frequently methylated/deleted in NSCLC, only a few were already known tumor suppressor genes: RBSP3 (CTDSPL), VHL and THRB. The RPL32, LOC285205, FGD5 and other genes were previously not shown to be involved in lung carcinogenesis. Ten methylated genes, i.e., IQSEC1, RBSP3, ITGA9, FOXP1, LRRN1, GNAI2, VHL, FGD5, ALDH1L1 and BCL6 were tested for expression by qPCR and were found downregulated in the majority of cases. Three genes (RBSP3, FBLN2 and ITGA9) demonstrated strong cell growth inhibition activity. A comprehensive statistical analysis suggested the set of 19 gene markers, ANKRD28, BHLHE40, CGGBP1, RBSP3, EPHB1, FGD5, FOXP1, GORASP1/TTC21, IQSEC1, ITGA9, LOC285375, LRRC3B, LRRN1, MITF, NKIRAS1/RPL15, TRH, UBE2E2, VHL, WNT7A, to allow early detection, tumor progression, metastases and to discriminate between SCC and ADC with sensitivity and specificity of 80-100%.
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| 10. |
- Dremov, Viacheslav V., et al.
(författare)
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Local Josephson vortex generation and manipulation with a Magnetic Force Microscope
- 2019
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Josephson vortices play an essential role in superconducting quantum electronics devices. Often seen as purely conceptual topological objects, 2π-phase singularities, their observation and manipulation are challenging. Here we show that in Superconductor—Normal metal—Superconductor lateral junctions Josephson vortices have a peculiar magnetic fingerprint that we reveal in Magnetic Force Microscopy (MFM) experiments. Based on this discovery, we demonstrate the possibility of the Josephson vortex generation and manipulation by the magnetic tip of a MFM, thus paving a way for the remote inspection and control of individual nano-components of superconducting quantum circuits.
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