| 1. |
|
|
| 2. |
- Blanchart, P., et al.
(författare)
-
Mechanism of traditional Bogolan dyeing technique with clay on cotton fabric
- 2010
-
Ingår i: Applied Clay Science. - : Elsevier BV. - 0169-1317 .- 1872-9053. ; 50:4, s. 455-460
-
Tidskriftsartikel (refereegranskat)abstract
- Bogolan is a traditional dyeing technique deeply rooted in Mali It uses local clays from Niger River region and a leave extract from N galama trees (Anogeissus leiocarpa) The clay contains a significant amount of iron (hydr)oxides mainly akaganeite It reacts with N galama coating onto cotton to form black or brown colors UV/Vis and IR spectroscopy indicated very similar behavior of N galama leaves extract and carboxylic aromatic acids mainly ellagic or gallic acids which form dark colored complexes with iron Since iron (hydr) oxides are coated on clay mineral particles they contribute to the fixation of the Clay mineral particles and also cause the dark color X-ray diffraction of oriented tissue and SEM observations confirmed the presence of clay particles attached on the fiber surface.
|
|
| 3. |
- Colpi, G. M., et al.
(författare)
-
European Academy of Andrology guideline Management of oligo-astheno-teratozoospermia
- 2018
-
Ingår i: Andrology. - : Wiley. - 2047-2919. ; 6:4, s. 513-524
-
Forskningsöversikt (refereegranskat)abstract
- Background: Oligo-astheno-teratozoospermia is frequently reported in men from infertile couples. Its etiology remains, in the majority of cases, unknown with a variety of factors to contribute to its pathogenesis. The aim of this European Academy of Andrology guideline was to provide an overview of these factors and to discuss available management options. Materials and Methods: PubMed was searched for papers in English for articles with search terms: male infertility and oligo-astheno-teratozoospermia. For evidence-based recommendations, the GRADE system was applied. Issues related to urogenital infections/inflammations have not been included in this document as they will be covered by separate guidelines. Results: For men with oligo-astheno-teratozoospermia, the European Academy of Andrology recommends:. A general physical examination to assess signs of hypogonadism. A scrotal physical examination to assess (i) the testes and epididymes for volume and consistency, (ii) deferent ducts for total or partial absence, and (iii) occurrence of varicocoele. Performing two semen analyses, according to World Health Organization guidelines to define an oligo-astheno-teratozoospermia. An endocrine evaluation. A scrotal ultrasound as part of routine investigation. Karyotype analysis and assessment of Yq microdeletions in infertile men with a sperm concentration ≤5 × 106/mL. Cystic fibrosis transmembrane conductance regulator gene evaluation in case of suspicion for incomplete congenital obstruction of the genital tract. Against quitting physical activity to improve the chance of achieving pregnancy. Against androgen replacement therapy to improve the chance of achieving pregnancy. Assisted reproduction techniques to improve the chance of achieving pregnancy, in case other treatment options are not available or not efficient. Androgen replacement therapy in patients with biochemical/clinical signs of hypogonadism, after completion of the fertility treatment. Conclusion: These guidelines can be applied in clinical work and indicate future research needs.
|
|
| 4. |
- Goldfarb, Y, et al.
(författare)
-
Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation
- 2021
-
Ingår i: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 218:11
-
Tidskriftsartikel (refereegranskat)abstract
- The autoimmune regulator (AIRE) is essential for the establishment of central tolerance and prevention of autoimmunity. Interestingly, different AIRE mutations cause autoimmunity in either recessive or dominant-negative manners. Using engineered mouse models, we establish that some monoallelic mutants, including C311Y and C446G, cause breakdown of central tolerance. By using RNAseq, ATACseq, ChIPseq, and protein analyses, we dissect the underlying mechanisms for their dominancy. Specifically, we show that recessive mutations result in a lack of AIRE protein expression, while the dominant mutations in both PHD domains augment the expression of dysfunctional AIRE with altered capacity to bind chromatin and induce gene expression. Finally, we demonstrate that enhanced AIRE expression is partially due to increased chromatin accessibility of the AIRE proximal enhancer, which serves as a docking site for AIRE binding. Therefore, our data not only elucidate why some AIRE mutations are recessive while others dominant, but also identify an autoregulatory mechanism by which AIRE negatively modulates its own expression.
|
|
| 5. |
- Haasen, C., et al.
(författare)
-
Cocaine use in Europe - a multi-centre study : Methodology and prevalence estimates
- 2004
-
Ingår i: European Addiction Research. - 1022-6877 .- 1421-9891. ; 10:4, s. 139-146
-
Tidskriftsartikel (refereegranskat)abstract
- An increase in the use of cocaine and crack in several parts of Europe has raised the question whether this trend is similar to that of the USA in the 1980s. However, research in the field of cocaine use in Europe has been only sporadic. Therefore, a European multi-centre and multi-modal project was designed to study specific aspects of cocaine and crack use in Europe, in order to develop guidelines for public health strategies. Data on prevalence rates were analysed for the general population and for specific subgroups. Despite large differences between countries in the prevalence of cocaine use in the general population, most countries show an increase in the last few years. The highest rate with a lifetime prevalence of 5.2% was found for the United Kingdom, although with a plateau effect around the year 2000. With regard to specific subgroups, three groups seem to show a higher prevalence than the general population: (1) youth, especially in the party scene; (2) socially marginalized groups, such as homeless and prostitutes or those found in open drug scenes; (3) opiate-dependent patients in maintenance treatment who additionally use cocaine. Specific strategies need to be developed to address problematic cocaine use in these subgroups.
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
- Prinzleve, M., et al.
(författare)
-
Cocaine use in Europe - a multi-centre study : Patterns of use in different groups
- 2004
-
Ingår i: European Addiction Research. - 1022-6877 .- 1421-9891. ; 10:4, s. 147-155
-
Tidskriftsartikel (refereegranskat)abstract
- AIM: The study investigates patterns of cocaine powder and crack cocaine use of different groups in nine European cities. DESIGN, SETTING, PARTICIPANTS: Multi-centre cross-sectional study conducted in Barcelona, Budapest, Dublin, Hamburg, London, Paris, Rome, Vienna, and Zurich. Data were collected by structured face-to-face interviews. The sample comprises 1,855 cocaine users out of three subgroups: 632 cocaine users in addiction treatment, mainly maintenance treatment; 615 socially marginalized cocaine users not in treatment, and 608 socially integrated cocaine users not in treatment. MEASUREMENTS: Use of cocaine powder, crack cocaine and other substances in the last 30 days, routes of administration, and lifetime use of cocaine powder and crack cocaine. Findings: The marginalized group showed the highest intensity of cocaine use, the highest intensity of heroin use and of multiple substance use. 95% of the integrated group snorted cocaine powder, while in the two other groups, injecting was quite prevalent, but with huge differences between the cities. 96% of all participants had used at least one other substance in addition to cocaine in the last 30 days. CONCLUSIONS: The use of cocaine powder and crack cocaine varies widely between different groups and between cities. Nonetheless, multiple substance use is the predominating pattern of cocaine use, and the different routes of administration have to be taken into account.
|
|
