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- Wang, Z., et al.
(author)
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Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
- 2022
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 54:9, s. 1332-1344
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Journal article (peer-reviewed)abstract
- Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention. Multi-ancestry meta-analyses of genome-wide association studies for self-reported physical activity during leisure time, leisure screen time, sedentary commuting and sedentary behavior at work identify 99 loci associated with at least one of these traits.
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| 2. |
- Horellou, Cathy, 1967, et al.
(author)
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The XXL Survey: XXXIV. Double Irony in XXL-North: A tale of two radio galaxies in a supercluster at z = 0.14
- 2018
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 620
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Journal article (peer-reviewed)abstract
- Aims. We show how the XXL multiwavelength survey can be used to shed light on radio galaxies and their environment. Methods. Two prominent radio galaxies were identified in a visual examination of the mosaic of XXL-North obtained with the Giant Metrewave Radio Telescope at 610 MHz. Counterparts were searched for in other bands. Spectroscopic redshifts from the GAMA database were used to identify clusters and/or groups of galaxies, estimate their masses with the caustic method, and quantify anisotropies in the surrounding galaxy distribution via a Fourier analysis. Results. Both radio galaxies are of FR I type and are hosted by early-type galaxies at a redshift of 0.138. The first radio source, named the Exemplar, has a physical extent of ∼400 kpc; it is located in the cluster XLSSC 112, which has a temperature of ∼2 keV, a total mass of ∼1014 Mo, and resides in an XXL supercluster with eight known members. The second source, named the Double Irony, is a giant radio galaxy with a total length of about 1.1 Mpc. Its core coincides with a cataloged point-like X-ray source, but no extended X-ray emission from a surrounding galaxy cluster was detected. However, from the optical data we determined that the host is the brightest galaxy in a group that is younger, less virialized, and less massive than the Exemplar's cluster. A friends-of-friends analysis showed that the Double Irony's group is a member of the same supercluster as the Exemplar. There are indications that the jets and plumes of the Double Irony have been deflected by gas associated with the surrounding galaxy distribution. Another overdensity of galaxies (the tenth) containing a radio galaxy was found to be associated with the supercluster. Conclusions. Radio Galaxies can be used to find galaxy clusters/groups that are below the current sensitivity of X-ray surveys.
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