| 1. |
- Kroon, Ulla-Beth, et al.
(författare)
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Fast-track hysterectomy: a randomised, controlled study.
- 2010
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Ingår i: European journal of obstetrics, gynecology, and reproductive biology. - : Elsevier BV. - 1872-7654 .- 0301-2115. ; 151:2, s. 203-7
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Tidskriftsartikel (refereegranskat)abstract
- To investigate if intrathecally administered morphine combined with a low-dose mode of total intravenous anaesthesia (TIVA) accelerates recovery after abdominal surgery as compared, to patient-controlled analgesia (PCA) combined with anaesthesia, based on volatile anaesthetics.
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| 2. |
- Bengtsson, Samuel N., et al.
(författare)
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Free induction decay in the extreme ultraviolet
- 2015
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Ingår i: Proceedings of Frontiers in Optics 2015, FIO 2015. - 9781943580033
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Konferensbidrag (refereegranskat)abstract
- We present an experimental study of controlled Free Induction Decay (FID) in the extreme ultraviolet regime excited by High-order Harmonics. The control is done by applying a delayed infrared pulse.
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| 3. |
- Holmberg, Carl Jacob, et al.
(författare)
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The efficacy of immune checkpoint blockade for melanoma in-transit with or without nodal metastases - A multicenter cohort study
- 2022
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Ingår i: EUROPEAN JOURNAL OF CANCER. - : Elsevier BV. - 0959-8049 .- 1879-0852. ; 40:16
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Guidelines addressing melanoma in-transit metastasis (ITM) recommend immune checkpoint inhibitors (ICI) as a first-line treatment option, despite the fact that there are no efficacy data available from prospective trials for exclusively ITM disease. The study aims to analyze the outcome of patients with ITM treated with ICI based on data from a large cohort of patients treated at international referral clinics. Methods: A multicenter retrospective cohort study of patients treated between January 2015 and December 2020 from Australia, Europe, and the USA, evaluating treatment with ICI for ITM with or without nodal involvement (AJCC8 N1c, N2c, and N3c) and without distant disease (M0). Treatment was with PD-1 inhibitor (nivolumab or pembrolizumab) and/or CTLA-4 inhibitor (ipilimumab). The response was evaluated according to the RECIST criteria modified for cutaneous lesions. Results: A total of 287 patients from 21 institutions in eight countries were included. Immunotherapy was first-line treatment in 64 (22%) patients. PD-1 or CTLA-4 inhibitor monotherapy was given in 233 (81%) and 23 (8%) patients, respectively, while 31 (11%) received both in combination. The overall response rate was 56%, complete response (CR) rate was 36%, and progressive disease (PD) rate was 32%. Median PFS was ten months (95% CI 7.4-12.6 months) with a one-, two-, and five-year PFS rate of 48%, 33%, and 18%, respectively. Median MSS was not reached, and the one-, two-, and five-year MSS rates were 95%, 83%, and 71%, respectively. Conclusion: Systemic immunotherapy is an effective treatment for melanoma ITM. Future studies should evaluate the role of systemic immunotherapy in the context of multimodality therapy, including locoregional treatments such as surgery, intralesional therapy, and regional therapies.
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| 4. |
- Johansson, Magnus, et al.
(författare)
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Gap and out-gap solitons in modulated systems of finite length: exact solutions in the slowly varying envelope limit
- 2011
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Ingår i: PHYSICA SCRIPTA. - : Royal Swedish Academy of Sciences. - 0031-8949 .- 1402-4896. ; 83:6
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Tidskriftsartikel (refereegranskat)abstract
- We discuss nonlinear excitations in finite-size one-dimensional modulated systems. Considering a binary modulated discrete nonlinear Schrodinger chain of large but finite length with periodic boundary conditions, we obtain exact elliptic-function solutions corresponding to stationary excitations in the slowly varying envelope limit. From these solutions, we analyze how the transformation between (localized) gap and (delocalized) out-gap solitons manifests itself in a system of finite length. The analogue of a localized gap soliton appears through a bifurcation at a critical point, so that gap soliton analogues exist only for chains longer than a critical value, which scales inversely proportional to the modulation depth. The total norm of these gap-out-gap states is found to be a monotonic function of the frequency, always inside a nonlinear gap with edges defined by the main nonlinear modes which approach the linear spectrum gap boundaries in the small-amplitude limit. The transformation from a gap to an out-gap state is associated with a particular frequency, close to the lower boundary of the linear gap; at this point the elliptic functions become trigonometric, corresponding to a finite-size analogue of an algebraic soliton. We compare the scenario with earlier results obtained numerically for purely discrete chains with few degrees of freedom.
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| 5. |
- Kroon, Lars, et al.
(författare)
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Absence of localization in a model with correlation measure as a random lattice
- 2004
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - : American Physical Society. - 1098-0121 .- 1550-235X. ; 69:9, s. 094204-
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Tidskriftsartikel (refereegranskat)abstract
- A coherent picture of localization in one-dimensional aperiodically ordered systems is still missing. We show the presence of purely singular continuous spectrum for a discrete system whose modulation sequence has a correlation measure which is absolutely continuous, such as for a random sequence. The system showing these properties is modeled by the Rudin-Shapiro sequence, whose correlation measure even has a uniform density. The absence of localization is also supported by a numerical investigation of the dynamics of electronic wave packets showing weakly anomalous diffusion and an extremely slow algebraic decay of the temporal autocorrelation function.
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| 6. |
- Kroon, Lars, et al.
(författare)
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Bifurcation picture and stability of the gap and out-gap discrete solitons
- 2007
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Ingår i: Low temperature physics (Woodbury, N.Y., Print). - : AIP Publishing. - 1063-777X .- 1090-6517. ; 33:5, s. 481-483
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Tidskriftsartikel (refereegranskat)abstract
- The dynamics of a quaternary fragment of a discrete system of coupled nonlinear oscillators with modulated frequency parameters is investigated, and the stability of its gap and out-gap soliton-like excitations is studied.
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| 7. |
- Kroon, Lars
(författare)
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Cancellation of Acoustic Waves in Scattering Media
- 2015
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Ingår i: 9TH INTERNATIONAL CONGRESS ON ADVANCED ELECTROMAGNETIC MATERIALS IN MICROWAVES AND OPTICS (METAMATERIALS 2015). - : IEEE. - 9781479978366 ; , s. 157-159
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Konferensbidrag (refereegranskat)abstract
- We find scattering cancellation in diffusive transport of acoustics waves propagating through strongly scattering media and for ballistic sound in the long wavelength limit.
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| 8. |
- Kroon, Lars, 1968-
(författare)
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Delocalization in nonperiodic systems
- 2004
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The localization properties of non-interacting linear excitations in one-dimensional aperiodically ordered structures are investigated from a theoretical point of view. The models used have various relevance for real systems, like quasicrystals, photonic crystals, and deterministic aperiodic superlattices. The main objective is to gain a conceptual understanding of the localization phenomenon in different lattice models, especially with respect to their correlation measures.The localization properties of electronic wavefunctions in various nearest neighbor tight -binding models are studied in the framework of the dynamical systems induced by the trace maps of their corresponding transfer matrices. With a unit hopping and an on-site potential modulated by the Rudin-Shapiro sequence, which in analogy with a random potential has an absolutely continuous correlation measure, the electronic spectrum is proved to be purely singular continuous and of zero Lebesgue measure. The absence of localization is also confirmed by numerical simulations of the dynamics of electronic wavepackets showing weakly anomalous diffusion and an algebraic decay of the temporal autocorrelation function. These results are also found to be invariant under the introduction of correlated hopping integrals.The nature of localization of elastic vibrations in harmonic lattices is also studied. The generalized eigenvalue problem arising from classical interactions in diatomic chains can be mapped to mixed tight-binding models, which enables the use of the spectral theory of discrete Schrödinger operators. Like for the Rudin-Shapiro model, it is found that the vibrational spectra of harmonic chains with masses distributed according to the Thue-Morse sequence and the period-doubling sequence are purely singular continuous. These results are obtained by transforming the lattices to on-site models by the use of certain renormalization procedures.Remembering that the correlation measure of the T hue-Morse sequence is purely singular continuous, while that of the period-doubling sequence is pure point, these results strongly suggest that the criticality of localization in deterministic aperiodic lattices is generic and quite independent of the character of the correlation measure associated to the modeling sequence.
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| 9. |
- Kroon, Lars, et al.
(författare)
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Localization-delocalization in aperiodic systems
- 2002
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Ingår i: Physical Review B, Condensed matter and materials physics. - 1098-0121 .- 1550-235X. ; 66:9, s. 094204-
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Tidskriftsartikel (refereegranskat)abstract
- The question of localization in a one-dimensional tight-binding model with aperiodicity given by substitutions is discussed. Since the localization properties of the well-known Rudin-Shapiro chain is still far from well understood, partly due to the absence of rigorous analytical results, we introduce a sequence that has several features in common with the Rudin-Shapiro sequence. We derive a trace map for this system and prove analytically that the electron spectrum is singular continuous. Despite the extended (non-normalizable) nature of the corresponding wave functions, the states show strong localization for finite approximations of the chain. Similar localization properties are found for the Rudin-Shapiro chain, where earlier results have indicated a pure point spectrum. We compare the properties for two other physical systems, ordered according to the two discussed sequences; stationary electron transmission is studied through finite chains using a dynamical map, optical properties of dielectric multilayer structures are investigated.
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| 10. |
- Kroon, Lars, et al.
(författare)
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Neutral inclusions for diffusive acoustic fields
- 2017
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Ingår i: Journal of Sound and Vibration. - : ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. - 0022-460X .- 1095-8568. ; 295, s. 80-89
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Tidskriftsartikel (refereegranskat)abstract
- We predict scattering cancellation in diffusive transport of acoustics waves propagating through multiple scattering media in the stationary limit. This would enable sensing of diffusive sound without disrupting the exterior acoustic field. We present design schemes for making spherical or cylindrical core-shell structures with multiple layers, characterized by homogenous and isotropic diffusion coefficients, neutral to an arbitrary applied multipole field. The double-layered sphere is found to support transparency to two concurrent multipole fields and unique cloaking solutions of arbitrary multipole order. One extra degree of freedom is provided by every layer added to the core-shell structure which may be exploited with our iterative formula for effective diffusivity for cloaking of additional field terms. From this we pass over to the long wavelength limit of ballistic sound and provide formulas for effective mass densities of multi-layered structures in spherical and cylindrical geometries with respect to multipole pressure fields. (C) 2017 Elsevier Ltd. All rights reserved.
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