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- Jones, Gregory T., et al.
(författare)
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Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci
- 2017
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Ingår i: Circulation Research. - 0009-7330 .- 1524-4571. ; 120:2, s. 341-
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Tidskriftsartikel (refereegranskat)abstract
- Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA. Objective: To identify additional AAA risk loci using data from all available genome-wide association studies. Methods and Results: Through a meta-analysis of 6 genome-wide association study data sets and a validation study totaling 10 204 cases and 107 766 controls, we identified 4 new AAA risk loci: 1q32.3 (SMYD2), 13q12.11 (LINC00540), 20q13.12 (near PCIF1/MMP9/ZNF335), and 21q22.2 (ERG). In various database searches, we observed no new associations between the lead AAA single nucleotide polymorphisms and coronary artery disease, blood pressure, lipids, or diabetes mellitus. Network analyses identified ERG, IL6R, and LDLR as modifiers of MMP9, with a direct interaction between ERG and MMP9. Conclusions: The 4 new risk loci for AAA seem to be specific for AAA compared with other cardiovascular diseases and related traits suggesting that traditional cardiovascular risk factor management may only have limited value in preventing the progression of aneurysmal disease.
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- Liu, C. P., et al.
(författare)
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High-Speed 1.56-μm Multiple Quantum Well Asymmetric Fabry-Perot Modulator/Detector (AFPMD) for Radio-Over-Fibre Applications
- 2005
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Ingår i: Microwave Photonics, 2005. MWP 2005. International Topical Meeting on. - : IEEE. ; , s. 137-140
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Konferensbidrag (refereegranskat)abstract
- We have designed and fabricated air-bridged optical modulator/detectors with modulation bandwidth exceeding 15GHz, the highest yet reported for InGaAsP/InGaAsP MQW AFPMDs. Wavelength dependence of the modulated output power at microwave frequencies is reported for the first time and the wide optical bandwidths ( gt; 17nm) so measured suggest that the AFPMD can be used with low-cost uncooled CWDM lasers in radio-over-fibre applications.
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- Yu, Y. C., et al.
(författare)
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Enhanced linear dynamic range of asymmetric Fabry-Perot modulator/detector
- 2006
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Ingår i: IEEE Photonics Technology Letters. - : Institute of Electrical and Electronics Engineers (IEEE). - 1041-1135 .- 1941-0174. ; 18:12-sep, s. 1040-1042
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Tidskriftsartikel (refereegranskat)abstract
- An InGaAsP multiple-quantum-well asymmetric Fabry-Wrot modulator/detector has been developed for radio-over-fiber systems. The measured bandwidth is more than 6 GHz and the total insertion loss is 7.1 dB. The property of nonlinearity and spurious-free dynamic range (SFDR) has been studied theoretically. By optimizing the operation optical wavelength and bias voltage based on the numerical simulation, fifth-order nonlinearity dominates the intermodulation distortion and an SFDR of 101 dB center dot Hz(4/5) has been achieved experimentally.
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- Yu, Y. C., et al.
(författare)
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Enhanced linear dynamic range of asymmetric Fabry-Perot modulator/detector
- 2006
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Ingår i: IEEE Photonics Technology Letters. - : Institute of Electrical and Electronics Engineers (IEEE). - 1041-1135 .- 1941-0174. ; 18:08-maj, s. 770-772
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Tidskriftsartikel (refereegranskat)abstract
- An InGaAsP multiple-quantum-well asymmetric Fabry-Perot modulator/detector has been developed for radioover-fiber systems. The measured bandwidth is more than 6 GHz and the total insertion loss is 7.1 dB. The property of nonlinearity and spurious-free dynamic range (SFDR) has been studied theoretically. By optimizing the operation optical wavelength and bias voltage based on the numerical simulation, fifth-order nonlinearity dominates the intermodulation distortion and an SFDR of 101 dB. Hz(4/5) has been achieved experimentally.
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| 10. |
- Nelander, Rikard, et al.
(författare)
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Fingerprints of spatial charge transfer in Quantum Cascade Lasers
- 2007
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Ingår i: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 102, s. 1-113104
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Tidskriftsartikel (refereegranskat)abstract
- We show that mid-infrared transmission spectroscopy of a quantum cascade laser provides clear-cut information on changes in charge location at different bias. Theoretical simulations of the evolution of the gain/absorption spectrum for a lambda~7.4 µm InGaAs/AlInAs/InP quantum cascade laser have been compared with the experimental findings. Transfer of electrons between the ground states in the active region and the states in the injector goes hand in hand with a decrease of discrete intersubband absorption peaks and an increase of broad, high-energy absorption toward the continuum delocalized states above the barriers.
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