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- Bryois, J., et al.
(författare)
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Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease
- 2020
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 52:5, s. 482-493
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson’s disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson’s disease. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.
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| 2. |
- Feeney, Laura Marie, et al.
(författare)
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A geometric derivation of the probability of finding a relay in multi-rate networks
- 2004. - 1
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Konferensbidrag (refereegranskat)abstract
- Relaying can improve performance of a wireless network, especially when transmission modes with different distance/cost tradeoffs are available. Examples of such modes include data rates or transmission power. This paper geometrically analyzes the probability that a high-cost direct transmission can be replaced by a combination of low-cost relay transmissions. The main result of the analysis is a technology-agnostic characterization of a communication systems amenability to relaying strategies and some recommendations for how to structure such systems
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| 5. |
- Feeney, Laura Marie, et al.
(författare)
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Multi-rate relaying for performance improvement in IEEE 802.11 WLANs
- 2007. - 5
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Konferensbidrag (refereegranskat)abstract
- It is well known that the presence of nodes using a low data transmit rate has a disproportionate impact on the performance of an IEEE 802.11 WLAN. ORP is an opportunistic relay protocol that allows nodes to increase their effective transmit rate by replacing a low data rate transmission with a two-hop sequence of shorter range, higher data rate transmissions, using an intermediate node as a relay. ORP differs from existing protocols in discovering relays experimentally, by optimistically making frames available for relaying. Relays identify themselves as suitable relays by forwarding these frames. This approach has several advantages compared with previously proposed relay protocols: Most importantly, ORP does not rely on observations of received signal strength to infer the availability of relay nodes and transmit rates. We present analytic and simulation results showing that ORP improves the throughput by up to 40% in a saturated IEEE 802.11b network.
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