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1.	Dixon, PH, et al. (author) Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy 2009 In: Gut. - : BMJ. - 1468-3288 .- 0017-5749. ; 58:4, s. 537-544 Journal article (peer-reviewed)
2.	Dixon, PH, et al. (author) THE ROLE OF COMMON GENETIC VARIATION AROUND SIX CANDIDATE LOCI FOR SUSCEPTIBILITY TO INTRAHEPATIC CHOLESTASIS OF PREGNANCY 2010 In: HEPATOLOGY. - 0270-9139. ; 52:4, s. 479A-479A Conference paper (other academic/artistic)
3.	Leggat, DJ, et al. (author) Vaccination induces HIV broadly neutralizing antibody precursors in humans 2022 In: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 378:6623, s. 964- Journal article (peer-reviewed)abstract Broadly neutralizing antibodies (bnAbs) can protect against HIV infection but have not been induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare bnAb-precursor B cells. In a randomized, double-blind, placebo-controlled phase 1 clinical trial, the HIV vaccine–priming candidate eOD-GT8 60mer adjuvanted with AS01Bhad a favorable safety profile and induced VRC01-class bnAb precursors in 97% of vaccine recipients with median frequencies reaching 0.1% among immunoglobulin G B cells in blood. bnAb precursors shared properties with bnAbs and gained somatic hypermutation and affinity with the boost. The results establish clinical proof of concept for germline-targeting vaccine priming, support development of boosting regimens to induce bnAbs, and encourage application of the germline-targeting strategy to other targets in HIV and other pathogens.

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Type of publication: journal article (2); conference paper (1)

Type of content: peer-reviewed (2); other academic/artistic (1)

Author/Editor: Marschall, HU (2); Williamson, C (2); Chambers, J. (2); Glantz, A. (2); Lammert, F. (2); Roederer, M (1); show more...; Molokhia, M (1); Khan, SA (1); Hedestam, GBK (1); Koup, RA (1); Taylor, A (1); Lu, D. (1); Cagigi, A (1); Geary, M (1); Brand, J. (1); Thompson, RJ (1); Donnelly, J (1); Corcoran, MM (1); Schiffner, T (1); Whittaker, J. (1); Lombardo, A (1); Cottrell, CA (1); Menis, S (1); Schief, WR (1); Crotty, S (1); Brown, DM (1); deCamp, AC (1); Fulp, WJ (1); Willis, JR (1); Kalyuzhniy, O (1); Leggat, DJ (1); Cohen, KW (1); Finak, G (1); Ballweber-Fleming, L (1); Srikanth, A (1); Plyler, JR (1); Rahaman, F (1); Philiponis, V (1); Whaley, RE (1); Seese, A (1); Ruppel, AM (1); Hoyland, W (1); Mahoney, CR (1); Ambrozak, DR (1); Sincomb, T (1); Mullen, TM (1); Maenza, J (1); Kolokythas, O (1); Khati, N (1); Bethony, J (1); show less...

University: Karolinska Institutet (3)

Language: English (3)

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