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- Chouke, Prashant B., et al.
(författare)
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Bioinspired metal/metal oxide nanoparticles: A road map to potential applications
- 2022
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Ingår i: Materials Today Advances. - : Elsevier Ltd. - 2590-0498. ; 16
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Tidskriftsartikel (refereegranskat)abstract
- Manufacturing of metal and metal oxide nanoparticles (M/MO NPs) in large quantities needed a strong reliable, sustainable, and eco-friendly protocol. Present work represents on biogenic approaches to fabricate green nanoparticles using green technology. The fabrications of M/MO NPs using natural bio-resources were engaged by means of alternative technique in place of conventional methods. These methods are naturally benign, straightforward, economical, and renewed technology; they does not content harmful chemicals, zero contaminants, and eco-friendly. The extracts from the biogenic resources are widely accepted owing to its capability to minimise and control the size and shape of metal and metal oxides NPs because of different structure directing agents, usually bioorganic phyto-chemicals. In this present review, we have summarized fabrication of different NPs like silver, gold, copper oxide, cobalt oxide, titanium oxide, cerium oxide, bismuth oxide, zinc oxide and nickel oxide nanoparticles using natural resources. The challenges, limiting factors and future directions of the bioinspired synthesis of metal/metal oxide NPs are also highlighted in this review. Moreover, biogenic materials has explored for further environmental remediation in terms of photocatalytic activity, elimination of organic waste, and antibacterial, antioxidant assay, and protein-metal complexes binding affinities by molecular docking.
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- Kopel, Pavel, et al.
(författare)
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Trithiocyanurate Complexes of Iron, Manganese and Nickel and Their Anticholinesterase Activity
- 2014
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Ingår i: Molecules. - : MDPI AG. - 1420-3049 .- 1420-3049. ; 19:4, s. 4338-4354
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Tidskriftsartikel (refereegranskat)abstract
- The complexes of Fe(II), Mn(II) and Ni(II) with a combination of a Schiff base, nitrogen-donor ligand or macrocyclic ligand and trithiocyanuric acid (ttcH(3)) were prepared and characterized by elemental analysis and spectroscopies. Crystal and molecular structures of the iron complex of composition [Fe(L-1)](ttcH(2))(ClO4)center dot EtOH center dot H2O (1), where L-1 is Schiff base derived from tris(2-aminoethyl)amine and 2-pyridinecarboxaldehyde, were solved. It was found that the Schiff base is coordinated to the central iron atom by six nitrogens forming deformed octahedral arrangement, whereas trithiocyanurate(1-) anion, perchlorate and solvent molecules are not coordinated. The X-ray structure of the Schiff base sodium salt is also presented and compared with the iron complex. The anticholinesterase activity of the complexes was also studied.
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- Soukup, O, et al.
(författare)
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Novel acetylcholinesterase reactivator K112 and its cholinergic properties.
- 2010
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Ingår i: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. - : Elsevier BV. - 1950-6007. ; 64:8, s. 541-5
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Tidskriftsartikel (refereegranskat)abstract
- The oxime reactivator K112 is a member of the new group of xylene linker-containing AChE reactivators. Its cholinergic properties could be of importance at OP poisoning and are not related to the AChE reactivation that has been studied. It has been found that, despite of reactivating potency, this compound has additional effects. These cholinergic effects include a weak inhibition of AChE (IC(50)=43.8+/-4.88muM), inhibition of binding to the porcine muscarinic M2 receptor (IC(50)=4.36muM) and finally, the inhibition of HACU (68.4+/-9.9%), a key regulatory step in the synthesis of ACh. The inhibition of the binding of (3H)-HC-3 (64.7+/-4.7%) and the influence on the membrane fluidity have also been observed. Blocking properties of K112 on the muscarinic receptors have been revealed in the in vitro experiment (rat urinary bladder) and in the in vivo experiment (rat heart BPM) as well. All these cholinergic properties could significantly contribute to the antidotal effect of K112 at the poisoning by the organophosphates.
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- Soukup, O, et al.
(författare)
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Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors.
- 2011
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Ingår i: Physiological research / Academia Scientiarum Bohemoslovaca. - 1802-9973. ; 60:4, s. 679-686
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Tidskriftsartikel (refereegranskat)abstract
- Current treatment of organophosphorus poisoning, resulting in overstimulation and desensitization of muscarinic and nicotinic receptors by acetylcholine (ACh), consists of the administration of atropine and oxime reactivators. However, no versatile oxime reactivator has been developed yet and some mortality still remains after application of standard atropine treatment, probably due to its lack of antinicotinic action. In our study, we focused on the interesting non-acetylcholinesterase property of oximes, i.e. antinicotinic effect of reactivators. Two standard reactivators (HI-6, obidoxime) and two new compounds (K027 and K203) were chosen and in vitro (patch clamp) and in vivo (nerve-evoked muscle contraction) testings were applied. Both examinations showed antinicotinic effects of the reactivators. In vitro inhibition of acetylcholine-evoked currents by obidoxime, HI-6 and K203 was equivalent while K027 was less potent. Similar order of potency was observed by the in vivo examiations. We thus confirm previous in vitro results, which describe antinicotinic effects of oxime reactivators, and furthermore, we show in vivo antagonism of oxime reactivators exerted by inhibition of the ACh effect on the nicotinic receptor in the neuromuscular junction. Taking together, the effects of tested oxime reactivators indicate an antagonism on both embryonic and adult form of the nicotinic receptors.
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- Soukup, Ondrej, et al.
(författare)
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The effect of oxime reactivators on muscarinic receptors: Functional and binding examinations.
- 2011
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Ingår i: Environmental toxicology and pharmacology. - : Elsevier BV. - 1872-7077 .- 1382-6689. ; 31:3, s. 364-70
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Tidskriftsartikel (refereegranskat)abstract
- The antidotal treatment of organophosphorus poisoning is still a problematic issue since no versatile antidote has been developed yet. In our study, we focused on an interesting property, which does not relate to the reactivation of inhibited acetylcholinesterase (AChE) of some oximes, but refers to their anti-muscarinic effects which may contribute considerably to their treatment efficacy. One standard reactivator (HI-6) and two new compounds (K027 and K203) have been investigated for their antimuscarinic properties. Anti-muscarinic effects were studies by means of an in vitro stimulated atrium preparation (functional test), the [(3)H]-QNB binding assay and G-protein coupled receptor assay (GPCR, beta-Arrestin Assay). Based on the functional data HI-6 demonstrates the highest anti-muscarinic effect. However, only when comparing [(3)H]-QNB binding results and GPCR data, K203 shows a very promising compound with regard to anti-muscarinic potency. The therapeutic impact of these findings has been discussed.
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- Soukup, Ondrej, et al.
(författare)
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The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors.
- 2013
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Ingår i: Archives of toxicology. - : Springer Science and Business Media LLC. - 1432-0738 .- 0340-5761. ; 87:4, s. 711-9
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Forskningsöversikt (refereegranskat)abstract
- Organophosphorus inhibitors (OP) of acetylcholinesterase (AChE) represent a group of highly toxic compounds. The treatment of OP intoxication is, however, insufficiently ensured. Currently, two main categories of drugs-anticholinergics and oxime reactivators- are employed as antidotes. Oximes have been reported to act at several levels of the cholinergic transmission, and among the non-reactivation effects, the interaction with cholinergic receptors stands out. This review addresses issues correlated with non-reactivating effects of oxime reactivators with a special focus on the muscarinic and nicotinic receptors, but involvement of other cholinergic structures such as AChE and choline uptake carriers are discussed too. It can be concluded that the oxime reactivators show a variation in their antagonistic effect on the muscarinic and nicotinic receptors, which is likely to be of significance in the treatment of OP poisoning. In vitro data reported oximes to exert higher efficacy on the muscarinic M2 subtype than on the AChE. However, this effect seemed to be subtype specific since the antagonistic M3 effect was lower. Also, and importantly, the antimuscarinic effect was larger than that on nicotinic receptors. Even though atropine showed a much higher muscarinic antagonism, it is supposed that non-reactivation properties of oxime reactivators play a significant role in the treatment of OP poisoning.
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