| 1. |
- Choudhury, Anmol, et al.
(författare)
-
Atmospheric microplastic and nanoplastic : The toxicological paradigm on the cellular system
- 2023
-
Ingår i: Ecotoxicology and Environmental Safety. - : Elsevier BV. - 0147-6513 .- 1090-2414. ; 259
-
Tidskriftsartikel (refereegranskat)abstract
- The increasing demand for plastic in our daily lives has led to global plastic pollution. The improper disposal of plastic has resulted in a massive amount of atmospheric microplastics (MPs), which has further resulted in the production of atmospheric nanoplastics (NPs). Because of its intimate relationship with the environment and human health, microplastic and nanoplastic contamination is becoming a problem. Because microplastics and nanoplastics are microscopic and light, they may penetrate deep into the human lungs. Despite several studies demonstrating the abundance of microplastics and nanoplastics in the air, the potential risks of atmospheric microplastics and nanoplastics remain unknown. Because of its small size, atmospheric nanoplastic character-ization has presented significant challenges. This paper describes sampling and characterization procedures for atmospheric microplastics and nanoplastics. This study also examines the numerous harmful effects of plastic particles on human health and other species. There is a significant void in research on the toxicity of airborne microplastics and nanoplastics upon inhalation, which has significant toxicological potential in the future. Further study is needed to determine the influence of microplastic and nanoplastic on pulmonary diseases.
|
|
| 2. |
- Naser, Shaikh Sheeran, et al.
(författare)
-
Posterity of nanoscience as lipid nanosystems for Alzheimer's disease regression
- 2023
-
Ingår i: MATERIALS TODAY BIO. - : Elsevier BV. - 2590-0064. ; 21
-
Tidskriftsartikel (refereegranskat)abstract
- Alzheimer's disease (AD) is a type of dementia that affects a vast number of people around the world, causing a great deal of misery and death. Evidence reveals a relationship between the presence of soluble A & beta; peptide aggregates and the severity of dementia in Alzheimer's patients. The BBB (Blood Brain Barrier) is a key problem in Alzheimer's disease because it prevents therapeutics from reaching the desired places. To address the issue, lipid nanosystems have been employed to deliver therapeutic chemicals for anti-AD therapy in a precise and targeted manner. The applicability and clinical significance of lipid nanosystems to deliver therapeutic chemicals (Galantamine, Nicotinamide, Quercetin, Resveratrol, Curcumin, HUPA, Rapamycin, and Ibuprofen) for anti-AD therapy will be discussed in this review. Furthermore, the clinical implications of the aforementioned therapeutic compounds for anti-AD treatment have been examined. Thus, this review will pave the way for researchers to fashion therodiagnostics approaches based on nanomedicine to overcome the problems of delivering therapeutic molecules across the blood brain barrier (BBB).
|
|
| 3. |
- Sinha, Adrija, et al.
(författare)
-
The translational paradigm of nanobiomaterials : Biological chemistry to modern applications
- 2022
-
Ingår i: MATERIALS TODAY BIO. - : Elsevier. - 2590-0064. ; 17
-
Tidskriftsartikel (refereegranskat)abstract
- Recently nanotechnology has evolved as one of the most revolutionary technologies in the world. It has now become a multi-trillion-dollar business that covers the production of physical, chemical, and biological systems at scales ranging from atomic and molecular levels to a wide range of industrial applications, such as electronics, medicine, and cosmetics. Nanobiomaterials synthesis are promising approaches produced from various biological elements be it plants, bacteria, peptides, nucleic acids, etc. Owing to the better biocompatibility and biological approach of synthesis, they have gained immense attention in the biomedical field. Moreover, due to their scaled -down sized property, nanobiomaterials exhibit remarkable features which make them the potential candidate for different domains of tissue engineering, materials science, pharmacology, biosensors, etc. Miscellaneous char-acterization techniques have been utilized for the characterization of nanobiomaterials. Currently, the commer-cial transition of nanotechnology from the research level to the industrial level in the form of nano-scaffolds, implants, and biosensors is stimulating the whole biomedical field starting from bio-mimetic nacres to 3D printing, multiple nanofibers like silk fibers functionalizing as drug delivery systems and in cancer therapy. The contribution of single quantum dot nanoparticles in biological tagging typically in the discipline of genomics and proteomics is noteworthy. This review focuses on the diverse emerging applications of Nanobiomaterials and their mechanistic advancements owing to their physiochemical properties leading to the growth of industries on different biomedical measures. Alongside the implementation of such nanobiomaterials in several drug and gene delivery approaches, optical coding, photodynamic cancer therapy, and vapor sensing have been elaborately discussed in this review. Different parameters based on current challenges and future perspectives are also dis-cussed here.
|
|
| 4. |
- Kirti, Apoorv, et al.
(författare)
-
Nanoparticle-mediated metronomic chemotherapy in cancer : A paradigm of precision and persistence
- 2024
-
Ingår i: Cancer Letters. - : Elsevier. - 0304-3835 .- 1872-7980. ; 594
-
Tidskriftsartikel (refereegranskat)abstract
- Current methods of cancer therapy have demonstrated enormous potential in tumor inhibition. However, a high dosage regimen of chemotherapy results in various complications which affect the normal body cells. Tumor cells also develop resistance against the prescribed drugs in the whole treatment regimen increasing the risk of cancer relapse. Metronomic chemotherapy is a modern treatment method that involves administering drugs at low doses continuously, allowing the drug sufficient time to take its effect. This method ensures that the toxicity of the drugs is to a minimum in comparison to conventional chemotherapy. Nanoparticles have shown efficacy in delivering drugs to the tumor cells in various cancer therapies. Combining nanoparticles with metronomic chemotherapy can yield better treatment results. This combination stimulates the immune system, improving cancer cells recognition by immune cells. Evidence from clinical and pre-clinical trials supports the use of metronomic delivery for drug-loaded nanoparticles. This review focuses on the functionalization of nanoparticles for improved drug delivery and inhibition of tumor growth. It emphasizes the mechanisms of metronomic chemotherapy and its conjunction with nanotechnology. Additionally, it explores tumor progression and the current methods of chemotherapy. The challenges associated with nano-based metronomic chemotherapy are outlined, paving the way for prospects in this dynamic field.
|
|
| 5. |
- Simnani, Faizan Zarreen, et al.
(författare)
-
Nanocarrier vaccine therapeutics for global infectious and chronic diseases
- 2023
-
Ingår i: Materials Today. - : Elsevier BV. - 1369-7021 .- 1873-4103. ; 66, s. 371-408
-
Tidskriftsartikel (refereegranskat)abstract
- Immunization has the potential to become a viable weapon for the upcoming pandemic and save millions of lives, while also dramatically lowering the high mortality rate brought on by a number of infectious and chronic illnesses. Despite the success of some vaccinations for infectious illnesses, obstacles remain in avoiding and creating fully protective vaccines. Current COVID-19 pandemic highlights need for vaccination platform improvements. Nanomaterials have been created as a possible nanocarrier to elicit a robust immune response against important global morbidity and mortality drivers by encapsulating targeted antigen and functionalizing nanoparticles with particular molecules. In addition to their application in cancer immunotherapy, nanocarriers are currently being included into the development of vaccines against human immunodeficiency virus (HIV), malaria, TB, and influenza. In order to evaluate conventional and next-generation vaccination platforms, this study focuses on the COVID-19 and cancer vaccine as well as the passage and interaction of nanoparticles with immune cells in the lymph node. It also draws attention to the gaps in current and future HIV, TB, malaria, and influenza vaccinations, as well as nanovaccines. The importance of the dose-dependent vaccine in inducing and maintaining neutralizing antibodies after immunization has been discussed in more detail.
|
|
| 6. |
- Kumar, Anmol, et al.
(författare)
-
GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function
- 2015
-
Ingår i: PLOS Genetics. - : PLoS. - 1553-7390 .- 1553-7404. ; 11:12
-
Tidskriftsartikel (refereegranskat)abstract
- Degeneration of nigrostriatal dopaminergic system is the principal lesion in Parkinson's disease. Because glial cell line-derived neurotrophic factor (GDNF) promotes survival of dopamine neurons in vitro and in vivo, intracranial delivery of GDNF has been attempted for Parkinson's disease treatment but with variable success. For improving GDNF-based therapies, knowledge on physiological role of endogenous GDNF at the sites of its expression is important. However, due to limitations of existing genetic model systems, such knowledge is scarce. Here, we report that prevention of transcription of Gdnf 3'UTR in Gdnf endogenous locus yields GDNF hypermorphic mice with increased, but spatially unchanged GDNF expression, enabling analysis of postnatal GDNF function. We found that increased level of GDNF in the central nervous system increases the number of adult dopamine neurons in the substantia nigra pars compacta and the number of dopaminergic terminals in the dorsal striatum. At the functional level, GDNF levels increased striatal tissue dopamine levels and augmented striatal dopamine release and re-uptake. In a proteasome inhibitor lactacystin-induced model of Parkinson's disease GDNF hypermorphic mice were protected from the reduction in striatal dopamine and failure of dopaminergic system function. Importantly, adverse phenotypic effects associated with spatially unregulated GDNF applications were not observed. Enhanced GDNF levels up-regulated striatal dopamine transporter activity by at least five fold resulting in enhanced susceptibility to 6-OHDA, a toxin transported into dopamine neurons by DAT. Further, we report how GDNF levels regulate kidney development and identify microRNAs miR-9, miR-96, miR-133, and miR-146a as negative regulators of GDNF expression via interaction with Gdnf 3'UTR in vitro. Our results reveal the role of GDNF in nigrostriatal dopamine system postnatal development and adult function, and highlight the importance of correct spatial expression of GDNF. Furthermore, our results suggest that 3'UTR targeting may constitute a useful tool in analyzing gene function.
|
|
| 7. |
- Rout, Jitendra Kumar, et al.
(författare)
-
Understanding large-scale network effects in detecting review spammers
- 2023
-
Ingår i: IEEE Transactions on Computational Social Systems. - : Institute of Electrical and Electronics Engineers (IEEE). - 2329-924X.
-
Tidskriftsartikel (refereegranskat)abstract
- Opinion spam detection is a challenge for online review systems and social forum operators. Opinion spamming costs businesses and people money since it deceives customers as well as automated opinion mining and sentiment analysis systems by bestowing undeserved positive opinions on target firms and/or bestowing fake negative opinions on others. One popular detection approach is to model a review system as a network of users, products, and reviews, for example using review graph models. In this article, we study the effects of network scale on network-based review spammer detection models, specifically on the trust model and the SpammerRank model. We then evaluate both network models using two large publicly available review datasets, namely: the Amazon dataset (containing 6 million reviews by more than 2 million reviewers) and the UCSD dataset (containing over 82 million reviews by 21 million reviewers). It has been observed thatSpammerRank model provides a better scaling time for applications requiring reviewer indicators and in case of trust model distributions are flattening out indicating variance of reviews with respect to spamming. Detailed observations on the scaling effects of these models are reported in the result section.
|
|
| 8. |
- Saha, Utsa, et al.
(författare)
-
Detrimental consequences of micropolymers associated plasticizers on endocrinal disruption
- 2024
-
Ingår i: MATERIALS TODAY BIO. - : Elsevier. - 2590-0064. ; 27
-
Tidskriftsartikel (refereegranskat)abstract
- The prevalence of polymer usage in everyday activities has emerged as a detriment to both human life and the environment. A large number of studies describe severe impacts of micropolymers (MP) and nanopolymers (NP) on various organ systems, including the endocrine system. Additionally, plasticizers utilized as additives have been identified as endocrine-disrupting chemicals (EDCs). MP/NP, along with associated plasticizers, affect principal signalling pathways of endocrine glands such as the pituitary, thyroid, adrenal, and gonads, thereby disrupting hormone function and metabolic processes crucial for maintaining homeostasis, fertility, neural development, and fetal growth. This review delves into the sources, distribution, and effects of micropolymers, nanopolymers, and associated plasticizers acting as EDCs. Furthermore, it provides a detailed review of the mechanisms underlying endocrine disruption in relation to different types of MP/NP.
|
|
