| 1. |
- Ghodrati, Behzad, et al.
(författare)
-
Product support logistics based on product design characteristics and operating environment
- 2003
-
Ingår i: Proceedings of the 38th annual International Logistics Conference and Exhibition. - : Society of Logistics Engineers.
-
Konferensbidrag (refereegranskat)abstract
- To improve the reliability, maintainability, and supportability (RMS) of a product, it is necessary to understand the factors influencing the product performance. This factors can be user environment, human (operator) aspects like training, and technical characteristics of the product. The environmental conditions in which the equipment is to be operated, such as temperature, humidity, dust, road conditions, maintenance facilities, maintenance crew training, operators' skill, etc, often have considerable influence directly on the product reliability and indirectly on the product supportability characteristics. Thus operating environment should be seriously considered while dimensioning product support and service delivery performance strategies, since it will have an impact on operational and maintenance cost and service quality to provide product support plan in an optimal condition. Spare parts are classified, as a product support items whose availability is important when planned or unplanned maintenance is to be carried out. Forecasting the required support/spare parts based on technical characteristics and operating environmental conditions of a system, is the one of the best ways for optimizing unplanned stoppages. This paper discusses about product support (required spare part) logistics based on product design characteristics and operating environment both for conventional and functional products.
|
|
| 2. |
- Ghodrati, Behzad, et al.
(författare)
-
Product support (spare parts procurement) strategy based on reliability characteristics and geographical location
- 2003
-
Ingår i: International Conference on Industrial Logistics. - Vaasa : University of Vaasa. - 952476010X ; , s. 222-235
-
Konferensbidrag (refereegranskat)abstract
- Product support, which is also referred to after sale service to the product is important for customer because it increases the availability of the product and it assures the expected function of the product in its operational phase. It gets affected by many factors such as - reliability and maintainability characteristics and geographical location of the product. By highlighting the reliability issues and geographical distribution of product in design and manufacturing phases, the product life cycle cost (LCC) can be optimized. One of the important steps in product design is the decision making for design out maintenance (DOM) and/or designs for maintenance (DFM). The DOM alternative leads to produce high reliable, and vice versa, whereas the DFM assure the similar performance with lower reliability. However, the need for product support and spare parts must be considered in both alternatives. The forecasting of required product support and spare parts based on reliability-maintainability characteristics is one approach for the product LCC optimization. Consequently, spare parts inventory management based on geographical distribution and reliability characteristics of the product can be also used as an alternative. This article describes a method to forecast the spare part requirements based on reliability estimation of the existing product under the influence of the product-operating environment. Subsequently the management of the spare parts inventory will be discussed based on the geographical location and required performance of the product.
|
|
| 3. |
- Kumar, Dhananjay, et al.
(författare)
-
Affordable phenotyping of winter wheat under field and controlled conditions for drought tolerance
- 2020
-
Ingår i: Agronomy. - : MDPI AG. - 2073-4395. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- Drought stress is one of the key plant stresses reducing grain yield in cereal crops worldwide. Although it is not a breeding target in Northern Europe, the changing climate and the drought of 2018 have increased its significance in the region. A key challenge, therefore, is to identify novel germplasm with higher drought tolerance, a task that will require continuous characterization of a large number of genotypes. The aim of this work was to assess if phenotyping systems with low-cost consumer-grade digital cameras can be used to characterize germplasm for drought tolerance. To achieve this goal, we built a proximal phenotyping cart mounted with digital cameras and evaluated it by characterizing 142 winter wheat genotypes for drought tolerance under field conditions. The same genotypes were additionally characterized for seedling stage traits by imaging under controlled growth conditions. The analysis revealed that under field conditions, plant biomass, relative growth rates, and Normalized Difference Vegetation Index (NDVI) from different growth stages estimated by imaging were significantly correlated to drought tolerance. Under controlled growth conditions, root count at the seedling stage evaluated by imaging was significantly correlated to adult plant drought tolerance observed in the field. Random forest models were trained by integrating measurements from field and controlled conditions and revealed that plant biomass and relative growth rates at key plant growth stages are important predictors of drought tolerance. Thus, based on the results, it can be concluded that the consumer-grade cameras can be key components of affordable automated phenotyping systems to accelerate pre-breeding for drought tolerance.
|
|
| 4. |
|
|
| 5. |
- Kumar, Dhananjay, et al.
(författare)
-
Reliability analysis of power transmission cables of electric mine loaders using the proportional hazards model
- 1992
-
Ingår i: Reliability Engineering & System Safety. - : Elsevier BV. - 0951-8320 .- 1879-0836. ; 37:3, s. 217-222
-
Tidskriftsartikel (refereegranskat)abstract
- The proportional hazards model (PHM) is a powerful technique which can be used to investigate the effects of operating environment and the diagnostic variables (covariates) associated with an item on its life length. The effects of two different designs and maintenance on the reliability of a power transmission cable of an electric mine loader is investigated using PHM. The purpose is to illustrate the application of this model in making decisions about selecting the proper material or designing an item to meet the required purpose efficiently. (11 refs.)
|
|
| 6. |
- Bhattacharyya, Dhananjay, et al.
(författare)
-
RNAHelix: computational modeling of nucleic acid structures with Watson-Crick and non-canonical base pairs
- 2017
-
Ingår i: Journal of Computer-Aided Molecular Design. - : SPRINGER. - 0920-654X .- 1573-4951. ; 31:2, s. 219-235
-
Tidskriftsartikel (refereegranskat)abstract
- Comprehensive analyses of structural features of non-canonical base pairs within a nucleic acid double helix are limited by the availability of a small number of three dimensional structures. Therefore, a procedure for model building of double helices containing any given nucleotide sequence and base pairing information, either canonical or non-canonical, is seriously needed. Here we describe a program RNAHelix, which is an updated version of our widely used software, NUCGEN. The program can regenerate duplexes using the dinucleotide step and base pair orientation parameters for a given double helical DNA or RNA sequence with defined Watson-Crick or non-Watson-Crick base pairs. The original structure and the corresponding regenerated structure of double helices were found to be very close, as indicated by the small RMSD values between positions of the corresponding atoms. Structures of several usual and unusual double helices have been regenerated and compared with their original structures in terms of base pair RMSD, torsion angles and electrostatic potentials and very high agreements have been noted. RNAHelix can also be used to generate a structure with a sequence completely different from an experimentally determined one or to introduce single to multiple mutation, but with the same set of parameters and hence can also be an important tool in homology modeling and study of mutation induced structural changes.
|
|
| 7. |
- Gubat, Johannes, 1986-, et al.
(författare)
-
Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action
- 2022
-
Ingår i: Frontiers in Oncology. - : Frontiers Media SA. - 2234-943X. ; 12
-
Tidskriftsartikel (refereegranskat)abstract
- Dienone compounds have been demonstrated to display tumor-selective anti-cancer activity independently of the mutational status of TP53. Previous studies have shown that cell death elicited by this class of compounds is associated with inhibition of the ubiquitin-proteasome system (UPS). Here we extend previous findings by showing that the dienone compound b-AP15 inhibits proteasomal degradation of long-lived proteins. We show that exposure to b-AP15 results in increased association of the chaperones VCP/p97/Cdc48 and BAG6 with proteasomes. Comparisons between the gene expression profile generated by b-AP15 to those elicited by siRNA showed that knock-down of the proteasome-associated deubiquitinase (DUB) USP14 is the closest related to drug response. USP14 is a validated target for b-AP15 and we show that b-AP15 binds covalently to two cysteines, Cys203 and Cys257, in the ubiquitin-binding pocket of the enzyme. Consistent with this, deletion of USP14 resulted in decreased sensitivity to b-AP15. Targeting of USP14 was, however, found to not fully account for the observed proteasome inhibition. In search for additional targets, we utilized genome-wide CRISPR/Cas9 library screening and Proteome Integral Solubility Alteration (PISA) to identify mechanistically essential genes and b-AP15 interacting proteins respectively. Deletion of genes encoding mitochondrial proteins decreased the sensitivity to b-AP15, suggesting that mitochondrial dysfunction is coupled to cell death induced by b-AP15. Enzymes known to be involved in Phase II detoxification such as aldo-ketoreductases and glutathione-S-transferases were identified as b-AP15-targets using PISA. The finding that different exploratory approaches yielded different results may be explained in terms of a “target” not necessarily connected to the “mechanism of action” thus highlighting the importance of a holistic approach in the identification of drug targets. We conclude that b-AP15, and likely also other dienone compounds of the same class, affect protein degradation and proteasome function at more than one level.
|
|
| 8. |
- Kumar, Dhananjay
(författare)
-
Identification of novel hypoxia-responsive factors in deep-water rice conferring tolerance to flood during germination
- 2020
-
Ingår i: Biologia Plantarum. - : Institute of Experimental Botany. - 0006-3134 .- 1573-8264. ; 64, s. 244-252
-
Tidskriftsartikel (refereegranskat)abstract
- Flood in rice fields at the time of seed sowing and early seedling establishment causes extensive crop loss due to the inability of the seeds to tolerate and overcome submergence. In the present study, rice genotypes from Assam, India tolerant to hypoxia during germination were identified through systematic screening of deep-water rice genotype collection from flood-prone ecosystem of Brahmaputra river valley. The difference in tolerance to hypoxia during germination within the species provides scope for identification of novel hypoxia-responsive factors involved in tolerance as mechanism of tolerance may not be conserved across tolerant gennplasms. Tolerant genotypes were further subjected to physiological and molecular characterization. Growth rate kinetics in tolerant genotypes new Rangdhakekua bao (RKB) and cultivar Khao Hlan On (KHO) from International Rice Research Institute (IRRI) used as positive control exhibited stronger escape strategy under hypoxic condition compared to sensitive genotype IR-64 (negative control). Activities of a-amylase and pyruvate decarboxylase were significantly higher in RKB and KHO than in IR-64, while no significant difference was observed in the alcohol dehydrogenase activity. Reverse transcription quantitative PCR confirmed increased amounts of transcripts of sucrose nonfermenting I related protein kinase, myeloblastosis-related protein S1, rice amylase 3D, and trehalose phosphate phosphatase 7 genes, which are known to be involved in hypoxia signaling cascade. Besides, transcription factors (TFs) like ethylene responce factors 71 and 63, ethylene insensitive 3-like la and proteins like cxpansins A7 and A2, which are involved in cell elongation had also significantly higher amounts in RKB compared to IR64. Additional factors that include TFs like ERF71 and FRF63 that shows perturbation at transcription even within tolerant genotypes might constitute the genotype-specific regulation, evolved as a part of its adaptive mechanism to survive under submerged conditions.
|
|
| 9. |
- Kumar, Dhananjay, et al.
(författare)
-
Maintenance scheduling under age replacement policy using proportional hazards model and TTT-plotting
- 1997
-
Ingår i: European Journal of Operational Research. - 0377-2217 .- 1872-6860. ; 99:3, s. 507-515
-
Tidskriftsartikel (refereegranskat)abstract
- The failure characteristics of a system may depend on the total operating time, operating time since the last repair, failure history, operating conditions or on the values of monitored variables. A reliability based approach which takes into consideration values of monitored variables is suggested for estimating the optimum maintenance (or replacement) time interval for a system or threshold values of monitored variables under the age replacement policy. The maintenance cost equation is formed on the basis of the planned and unplanned maintenance costs and the values of monitored variables. The proportional hazards model is used to identify the importance of monitored variables. The reliability function is estimated considering the values of monitored variables. A total time on test (TTT) plot based on this estimate of the reliability function is used to estimate the optimum maintenance (or replacement) time interval for a system or threshold values of monitored variables. This approach is illustrated with an example.
|
|
| 10. |
- Kumar, Dhananjay, et al.
(författare)
-
Proportional hazards model : an application to power supply cables of electric mine loaders
- 1994
-
Ingår i: International Journal of Reliability, Quality and Safety Engineering (IJRQSE). - 0218-5393. ; 1:3, s. 337-352
-
Tidskriftsartikel (refereegranskat)abstract
- The electric power supply cable is one of the most critical components of an electric mine loader. The effects of operating conditions such as fault types, cable types, numbers and types of repair done, the machines on which these cables are used, are analyzed using the proportional hazards model. The relatively important operating conditions influencing the life length of the cable are identified and their magnitudes are estimated. Before fitting any model to the data, simple graphical tools have been used in formulating covariates and selecting the suitable model. The proportional hazards model is found to be an effective tool for analyzing the effects of covariates. Graphical methods have been used to test the goodness-of-fit of the proportional hazards model
|
|
