| 1. |
- Alavi, Ali, et al.
(författare)
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Dual Mode IR Position and State Transfer for Tangible Tabletops
- 2011
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Ingår i: Proceedings of the ACM International Conference on Interactive Tabletops and Surfaces. - New York, NY, USA : ACM. ; 1:1, s. 278-279
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Konferensbidrag (refereegranskat)abstract
- This paper presents a method for tracking multiple active tangible devices on tabletops. Most tangible devices for tabletops use infrared to send information about their position, orientation, and state. The method we propose can be realized as a tabletop system using a low-cost camera to detect position and a low-cost infrared (IR) receiver to detect the state of each device. Since two different receivers (camera and IR-receiver) are used simultaneously we call the method dual mode. Using this method, it is possible to use devices with a large variation of states simultaneously on a tabletop, thus having more interactive devices on the surface.
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| 2. |
- Alavi, Ali, et al.
(författare)
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Multi-State Device Tracking for Tangible Tabletops
- 2011
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Ingår i: Larsson, Thomas ; Kjelldahl, Lars ; Jää-Aro, Kai-Mikael (eds): Proceedings of SIGRAD 2011. Evaluations of Graphics and Visualization — Efficiency, Usefulness, Accessibility, Usability, November 17–18, 2011, KTH, Stockholm, Sweden. - 1650-3686. ; 1:1, s. 114-
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Konferensbidrag (refereegranskat)abstract
- On tangible tabletops, Tangible User Interfaces (TUIs) can signalize their identity, position, orientation, and state by active infrared light. This provides rich interaction capabilities in complex, dynamic scenarios. If TUIs have to transfer additional high-resolution information, many bits are required for each update. This has a negative impact on the overall update rate of the system. In the first part of this paper, we present an in-house map application where interaction with time-dependent contour lines may benefit from high-resolution TUI states. Prototypical TUI concepts such as slider, ruler, and dials further motivate the benefit of high-resolution tracking. In the second part of the paper, we depart from a device tracking overview and then show how tangible devices for tabletops typically use infrared (IR) emitters and a camera to send information about their position, orientation, and state. Since transferring many additional information bits via a normal camera-based tabletop system is not feasible anymore, we introduce next a new system setup that still offers a sufficiently high update rate for a smooth interaction. The new method can be realized as a tabletop system using a low-cost camera detecting position, combined with a low-cost infrared receiver detecting the state of each device. Since both kinds of sensors are used simultaneously we call the method “dual mode.” This method combines a camera-based tracking with the possibility to transfer an almost unlimited amount of states for each device.
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| 3. |
- Bathelt, Jens, et al.
(författare)
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Conceptual Design Approach For Mechatronic Systems Controlled by a Programmable Logic Controller (PLC)
- 2003
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Konferensbidrag (refereegranskat)abstract
- Traditionally, the development of mechatronic systems starts with the mechanical design. Later electronic components and program logic for the product are added. This work proposes an improved interdisciplinary concurrent product development process with an enhanced function structure for the conceptual design phase. The new methodology is based on the German guideline VDI 2221 [1]. Transition conditions, time aspects and logic flow are added to the normal function structure. An example shows how to use the improved function structure. The enhanced function structure is used to derive the initial logic for the development of the PLC program controlling the machine later on. Since the extended function structure also covers the traditional information, it can still be used when building the assembly tree. By adding more information in the neutral function structure, the same information can be used for the mechanical design as well as for the electronic and logical design. The interdisciplinary communication and documentation among the engineers will be improved and errors in the concept will be detected earlier.
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| 4. |
- Bauer, Michael, et al.
(författare)
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Association between solar insolation and a history of suicide attempts in bipolar I disorder.
- 2019
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Ingår i: Journal of psychiatric research. - : Elsevier BV. - 1879-1379 .- 0022-3956. ; 113, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- In many international studies, rates of completed suicide and suicide attempts have a seasonal pattern that peaks in spring or summer. This exploratory study investigated the association between solar insolation and a history of suicide attempt in patients with bipolar I disorder. Solar insolation is the amount of electromagnetic energy from the Sun striking a surface area on Earth. Data were collected previously from 5536 patients with bipolar I disorder at 50 collection sites in 32 countries at a wide range of latitudes in both hemispheres. Suicide related data were available for 3365 patients from 310 onset locations in 51 countries. 1047 (31.1%) had a history of suicide attempt. There was a significant inverse association between a history of suicide attempt and the ratio of mean winter solar insolation/mean summer solar insolation. This ratio is smallest near the poles where the winter insolation is very small compared to the summer insolation. This ratio is largest near the equator where there is relatively little variation in the insolation over the year. Other variables in the model that were positively associated with suicide attempt were being female, a history of alcohol or substance abuse, and being in a younger birth cohort. Living in a country with a state-sponsored religion decreased the association. (All estimated coefficients p<0.01). In summary, living in locations with large changes in solar insolation between winter and summer may be associated with increased suicide attempts in patients with bipolar disorder. Further investigation of the impacts of solar insolation on the course of bipolar disorder is needed.
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| 5. |
- Bonagas, Nadilly, et al.
(författare)
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Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
- 2022
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Ingår i: NATURE CANCER. - : Springer Science and Business Media LLC. - 2662-1347. ; 3:2, s. 156-
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Tidskriftsartikel (refereegranskat)abstract
- The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical development. In the present study, we demonstrate a role for MTHFD2 in DNA replication and genomic stability in cancer cells, and perform a drug screen to identify potent and selective nanomolar MTHFD2 inhibitors; protein cocrystal structures demonstrated binding to the active site of MTHFD2 and target engagement. MTHFD2 inhibitors reduced replication fork speed and induced replication stress followed by S-phase arrest and apoptosis of acute myeloid leukemia cells in vitro and in vivo, with a therapeutic window spanning four orders of magnitude compared with nontumorigenic cells. Mechanistically, MTHFD2 inhibitors prevented thymidine production leading to misincorporation of uracil into DNA and replication stress. Overall, these results demonstrate a functional link between MTHFD2-dependent cancer metabolism and replication stress that can be exploited therapeutically with this new class of inhibitors. Helleday and colleagues describe a nanomolar MTHFD2 inhibitor that causes replication stress and DNA damage accumulation in cancer cells via thymidine depletion, demonstrating a potential therapeutic strategy in AML tumors in vivo.
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| 6. |
- Chen, S., et al.
(författare)
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SEMarbeta: Mobile sketch-gesture-video remote support for car drivers
- 2013
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Ingår i: ACM International Conference Proceeding Series. - New York, NY, USA : ACM. - 9781450319041 ; , s. 69-76
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Konferensbidrag (refereegranskat)abstract
- Uneven knowledge distribution is often an issue in remote support systems, creating the occasional need for additional information layers that extend beyond plain videoconference and shared workspaces. This paper introduces SEMarbeta, a remote support system designed for car drivers in need of help from an officebound professional expert. We introduce a design concept and its technical implementation using low-cost hardware and techniques inspired by augmented reality research. In this setup, the driver uses a portable Android tablet PC while the expert mechanic uses a stationary computer equipped with a video camera capturing his gestures and sketches. Hence, verbal instructions can be combined with supportive gestures and sketches added by the expert mechanic to the car's video display. To validate this concept, we carried out a user study involving two typical automotive repair tasks: checking engine oil and examining fuses. Based on these tasks and following a between-group (drivers and expert mechanics) design, we compared voice-only with additional sketch- and gesture-overlay on video screenshots measuring objective and perceived quality of help. Results indicate that sketch- and gesture-overlay can benefit remote car support in typical breakdown situations.
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| 7. |
- Costanza, Enrico, et al.
(författare)
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Mixed Reality: Survey
- 2009
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Ingår i: D. Lalanne, M. Stolze, J. Kohlas (Ed.) Human Machine Interaction: Research Results of the MMI Program. - 9783642004360 ; :LNCS 5440, s. 22-
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This chapter presents an overview of the Mixed Reality (MR) paradigm, which proposes to overlay our real-world environment with digital, computer-generated objects. It presents example applications and outlines limitations and solutions for their technical implementation. In MR systems, users perceive both the physical environment around them and digital elements presented through, for example, the use of semitransparent displays. By its very nature, MR is a highly interdisciplinary field engaging signal processing, computer vision, computer graphics, user interfaces, human factors, wearable computing, mobile computing, information visualization, and the design of displays and sensors. This chapter presents potential MR applications, technical challenges in realizing MR systems, as well as issues related to usability and collaboration in MR. It separately presents a section offering a selection of MR projects which have either been partly or fully undertaken at Swiss universities and rounds off with a section on current challenges and trends.
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| 8. |
- Feicht, Patrick, et al.
(författare)
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Systematic evaluation of different types of graphene oxide in respect to variations in their in-plane modulus
- 2017
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Ingår i: Carbon. - : Elsevier. - 0008-6223 .- 1873-3891. ; 114, s. 700-705
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Tidskriftsartikel (refereegranskat)abstract
- Graphene oxide samples prepared in various laboratories following a diversity of synthesis protocols based on Brodie's (BGO) and Hummers/Offeman's (HGO) methods were compared in respect of their in plane moduli. A simple wrinkling method allowed for a spatial resolution <1.5 pm by converting the wrinkling frequency. Quite surprisingly, a drastic variation of the in-plane moduli was found spanning the range from 600 GPa for the best BGO types, which is in the region of chemically derived graphene, all the way down to less than 200 GPa for HGO types. This would suggest that there are no two equal GO samples and GO should not be regarded a compound but rather a class of materials with very variable physical properties. While large differences between Brodie's and Hummers/Offeman's types might have been expected, even within the group of Hummers/Offeman's types pronounced differences are observed that, based on C-13 solid-state NMR, were related to over-functionalization versus over-oxidation.
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| 9. |
- Flavin, Richard, et al.
(författare)
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SPINK1 protein expression and prostate cancer progression
- 2014
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Ingår i: Clinical Cancer Research. - Philadelphia, USA : American Association for Cancer Research. - 1078-0432 .- 1557-3265. ; 20:18, s. 4904-11
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: SPINK1 overexpression has been described in prostate cancer and is linked with poor prognosis in many cancers. The objective of this study was to characterize the association between SPINK1 overexpression and prostate cancer-specific survival.Experimental design: The study included 879 participants in the U.S. Physicians' Health Study and Health Professionals Follow-Up Study, diagnosed with prostate cancer (1983-2004) and treated by radical prostatectomy. Protein tumor expression of SPINK1 was evaluated by immunohistochemistry on tumor tissue microarrays.Results: Seventy-four of 879 (8%) prostate cancer tumors were SPINK1 positive. Immunohistochemical data were available for PTEN, p-Akt, pS6, stathmin, androgen receptor (AR), and ERG (as a measure of the TMPRSS2:ERG translocation). Compared with SPINK1-negative tumors, SPINK1-positive tumors showed higher PTEN and stathmin expression, and lower expression of AR (P < 0.01). SPINK1 overexpression was seen in 47 of 427 (11%) ERG-negative samples and in 19 of 427 (4%) ERG-positive cases (P = 0.0003). We found no significant associations between SPINK1 status and Gleason grade or tumor stage. There was no association between SPINK1 expression and biochemical recurrence (P = 0.56). Moreover, there was no association between SPINK1 expression and prostate cancer mortality (there were 75 lethal cases of prostate cancer during a mean of 13.5 years follow-up; HR = 0.71; 95% confidence interval, 0.29-1.76).Conclusions: Our results suggest that SPINK1 protein expression may not be a predictor of recurrence or lethal prostate cancer amongst men treated by radical prostatectomy. SPINK1 and ERG protein expression do not seem to be entirely mutually exclusive, as some previous studies have suggested.
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| 10. |
- Fuchs, Matthias, et al.
(författare)
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E-Business Readiness, Intensity, and Impact : An Austrian Destination Management Organization Study
- 2010
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Ingår i: Journal of Travel Research. - : Sage Publications. - 0047-2875. ; 49:2, s. 165-178
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Tidskriftsartikel (refereegranskat)abstract
- The majority of today’s information and communication technology (ICT) impact studies disregard infrastructural, organizational, and environmental factors typically responsible for successful e-business adoption and use. This article proposes an empirical approach that shows how the mentioned factors determine both e-business adoption and the impact of information and communication technologies. The research framework is based on E. Rogers’ Innovation Diffusion Theory and is tested with survey data gathered in the Austrian destination management organization sector. By referring to K. Zhu and K. L. Kraemer’s (2005) e-business impact model, the proposed approach explicates how the use of e-business applications may positively affect the performance of tourism organizations. Online survey data are analyzed through a linear structural equation modeling approach.
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