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| 2. |
- Edgecock, T. R., et al.
(författare)
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High intensity neutrino oscillation facilities in Europe
- 2013
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Ingår i: Physical Review Special Topics - Accelerators and Beams. - : American Physical Society. - 1098-4402. ; 16:2, s. 021002-
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Tidskriftsartikel (refereegranskat)abstract
- The EUROnu project has studied three possible options for future, high intensity neutrino oscillation facilities in Europe. The first is a Super Beam, in which the neutrinos come from the decay of pions created by bombarding targets with a 4 MW proton beam from the CERN High Power Superconducting Proton Linac. The far detector for this facility is the 500 kt MEMPHYS water Cherenkov, located in the Frejus tunnel. The second facility is the Neutrino Factory, in which the neutrinos come from the decay of mu(+) and mu(-) beams in a storage ring. The far detector in this case is a 100 kt magnetized iron neutrino detector at a baseline of 2000 km. The third option is a Beta Beam, in which the neutrinos come from the decay of beta emitting isotopes, in particular He-6 and Ne-18, also stored in a ring. The far detector is also the MEMPHYS detector in the Frejus tunnel. EUROnu has undertaken conceptual designs of these facilities and studied the performance of the detectors. Based on this, it has determined the physics reach of each facility, in particular for the measurement of CP violation in the lepton sector, and estimated the cost of construction. These have demonstrated that the best facility to build is the Neutrino Factory. However, if a powerful proton driver is constructed for another purpose or if the MEMPHYS detector is built for astroparticle physics, the Super Beam also becomes very attractive.
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| 4. |
- Kurup, Dhanesh G., 1969-
(författare)
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Active and Passive Unequally Spaced Reflect-Arrays and Elements of RF Integration Techniques
- 2003
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Using an array synthesis tool based on a modified differential evolution algorithm, it is shown that the position-phase synthesis exhibits improved pattern characteristics compared to both the phase only and position only synthesis of uniform amplitude antenna arrays. The design of an unequally spaced planar reflect-array and an active power combining reflect-array are presented. The unit cell of the active reflect-array consists of an amplifying active reflect-antenna designed using a novel dual polarized microstrip-T coupled patch antenna. Two modelling approaches are proposed for the active reflect-antenna and the modelling methods are compared with the experiments.A computationally efficient analysis of an H-slot in the ground plane of a microstripline is carried out using a transmission line model. To improve the accuracy in the resonant region of the H-slot and retaining the computational efficiency, an artificial neural network is combined with an efficient spectral domain method. An efficient analysis tool for a silicon micromachined H-slot coupled antenna is developed by combining the transmission line models of the H-slot and an aperture coupled antenna. The experimental results are compared with the theory showing good agreement.The analysis and design of a microwave amplifier based on non-resonant slot matching is carried out. It is seen that the designed slot matched amplifier has decreased layout size, improved gain and noise figure characteristics compared to a stub matched amplifier. An efficient method for the analysis of non-resonant slots is compared with other approaches showing good agreement. This points to the fact that non-resonant slot matched circuits can be designed with the same speed and efficiency as we design the traditional stub based matching circuits.To address the problem of bandwidth and performance of reflect-arrays we propose a dielectric resonator antenna with slotline stubs. As a preliminary step we design a dielectric resonator antenna with slotline feed and the experimental results are compared with those of a commercial CAD tool. Design and analysis of 3D interconnects based on non-radiative dielectric waveguides is carried out. At millimeterwave, these interconnects are useful for hybrid and multilayer integration techniques.
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| 5. |
- Kurup, S, et al.
(författare)
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Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment
- 2006
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Ingår i: Biochemical Society Transactions. - 0300-5127 .- 1470-8752. ; 34:Pt 3, s. 454-455
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Tidskriftsartikel (refereegranskat)abstract
- HS (heparan sulphate) plays a key role in angiogenesis, by interacting with growth factors required in the process. it has been proposed that HS controls the diffusion, and thus the availability, of platelet-derived growth factor B that is needed for pericyte recruitment around newly formed capillaries. The present paper summarizes our studies on the importance of HS structure in this regulatory process.
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| 7. |
- Smits, Nicole C., et al.
(författare)
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The heparan sulfate motif (GlcNS6S-IdoA2S)3, common in heparin, has a strict topography and is involved in cell behavior and disease
- 2010
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Ingår i: Journal of Biological Chemistry. - 0021-9258 .- 1083-351X. ; 285:52, s. 41143-41151
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Tidskriftsartikel (refereegranskat)abstract
- Heparan sulfate (HS) is a structurally complex polysaccharide that interacts with a broad spectrum of extracellular effector ligands and thereby is thought to regulate a diverse array of biologic processes. The specificity of HS-ligand interactions is determined by the arrangement of sulfate groups on HS, which creates distinct binding motifs. Biologically important HS motifs are expected to exhibit regulated expression. Yet, there is a profound lack of tools to identify such motifs; consequently, little is known of their structures and functions. We have identified a novel phage display-derived antibody (NS4F5) that recognizes a highly regulated HS motif (HS(NS4F5)), which we have rigorously identified as (GlcNS6S-IdoA2S)(3). HS(NS4F5) exhibits a restricted expression in healthy adult tissues. Blocking HS(NS4F5) on cells in culture resulted in reduced proliferation and enhanced sensitivity to apoptosis. HS(NS4F5) is upregulated in tumor endothelial cells, consistent with a role in endothelial cell activation. Indeed, TNF-α stimulated endothelial expression of HS(NS4F5), which contributed to leukocyte adhesion. In a mouse model of severe systemic AA amyloidosis, HS(NS4F5) was expressed within amyloid deposits, which were successfully detected by microSPECT imaging using NS4F5 as a molecularly targeted probe. Combined, our results demonstrate that NS4F5 is a powerful tool for elucidating the biological function of HS(NS4F5) and can be exploited as a probe to detect novel polysaccharide biomarkers of disease processes.
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