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- Shur, Vladimir, et al.
(författare)
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Nanoscale Domain Effects in Ferroelectrics. Formation and Evolution of Self-Assembled Structures in LiNbO3and LiTaO3
- 2007
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Ingår i: Ferroelectrics (Print). - : Informa UK Limited. - 0015-0193 .- 1563-5112. ; 354, s. 145-157
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Tidskriftsartikel (refereegranskat)abstract
- We discuss the most interesting nanoscale domain effects resulting in formation andevolution of self-assembled domain structures in various representatives of LiNbO3 andLiTaO3 family. Several exotic domain kinetic scenarios for complete suppression of theclassical wall motion have been revealed. It has been shown that the modification of thesurface layer allows to obtain: (1) the wall motion controlled by merging with nanoscaledomains generated in front of the moving wall and (2) the discrete switching by enlarge-ment of the web-like self-assembled ensemble of isolated domains. The formation ofnanoscale quasi-periodic and self-similar structures during cooling after pulse heatingwithout any application of external electric field was studied. It has been shown thatall experimental results can be explained, if the retardation of the bulk screening of thedepolarization field is taken into account.
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- Ivshina, Anna V., et al.
(författare)
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Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer
- 2006
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Ingår i: Cancer Research. - 0008-5472 .- 1538-7445. ; 66:21, s. 10292-10301
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Tidskriftsartikel (refereegranskat)abstract
- Histologic grading of breast cancer defines morphologic subtypes informative of metastatic potential, although not without considerable interobserver disagreement and clinical heterogeneity particularly among the moderately differentiated grade 2 (G2) tumors. We posited that a gene expression signature capable of discerning tumors of grade 1 (G1) and grade 3 (W) histology might provide a more objective measure of grade with prognostic benefit for patients with G2 disease. To this end, we studied the expression profiles of 347 primary invasive breast tumors analyzed on Affymetrix microarrays. Using class prediction algorithms, we identified 264 robust grade-associated markers, six of which could accurately classify G1 and G3 tumors, and separate G2 tumors into two highly discriminant classes (termed G2a and G2b genetic grades) with patient survival outcomes highly similar to those with G1 and G3 histology, respectively. Statistical analysis of conventional clinical variables further distinguished G2a and G2b subtypes from each other, but also from histologic G1 and G3 tumors. In multivariate analyses, genetic grade was consistently found to be an independent prognostic indicator of disease recurrence comparable with that of lymph node status and tumor size. When incorporated into the Nottingham prognostic index, genetic grade enhanced detection of patients with less harmful tumors, likely to benefit little from adjuvant therapy. Our findings show that a genetic grade signature can improve prognosis and therapeutic planning for breast cancer patients, and support the view that low- and high-grade disease, as defined genetically, reflect independent pathobiological entities rather than a continuum of cancer progression.
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- Lobov, A., et al.
(författare)
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Field induced evolution of regular and random 2D domain structures and shape of isolated domains in LiNbO3 and LiTaO3
- 2006
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Ingår i: Ferroelectrics (Print). - : Informa UK Limited. - 0015-0193 .- 1563-5112. ; 341:1, s. 109-116
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Tidskriftsartikel (refereegranskat)abstract
- The shapes of isolated domains produced by application of the uniform external electric field in different experimental conditions were investigated experimentally in single crystalline lithium niobate LiNbO3 and lithium tantalate LiTaO3. The study of the domain kinetics by computer simulation and experimentally by polarization reversal of the model structure using two-dimensional regular electrode pattern confirms applicability of the kinetic approach to explanation of the experimentally observed evolution of the domain shape and geometry of the domain structure. It has been shown that the fast domain walls strictly oriented along X directions appear after domain merging.
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- Rabe, Benjamin, et al.
(författare)
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The MOSAiC Distributed Network: Observing the coupled Arctic system with multidisciplinary, coordinated platforms
- 2024
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Ingår i: Elementa. - 2325-1026. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- Central Arctic properties and processes are important to the regional and global coupled climate system. The Multidisciplinary drifting Observatory for the Study of Arctic Climate (MOSAiC) Distributed Network (DN) of autonomous ice-tethered systems aimed to bridge gaps in our understanding of temporal and spatial scales, in particular with respect to the resolution of Earth system models. By characterizing variability around local measurements made at a Central Observatory, the DN covers both the coupled system interactions involving the ocean-ice-atmosphere interfaces as well as three-dimensional processes in the ocean, sea ice, and atmosphere. The more than 200 autonomous instruments (“buoys”) were of varying complexity and set up at different sites mostly within 50 km of the Central Observatory. During an exemplary midwinter month, the DN observations captured the spatial variability of atmospheric processes on sub-monthly time scales, but less so for monthly means. They show significant variability in snow depth and ice thickness, and provide a temporally and spatially resolved characterization of ice motion and deformation, showing coherency at the DN scale but less at smaller spatial scales. Ocean data show the background gradient across the DN as well as spatially dependent time variability due to local mixed layer sub-mesoscale and mesoscale processes, influenced by a variable ice cover. The second case (May–June 2020) illustrates the utility of the DN during the absence of manually obtained data by providing continuity of physical and biological observations during this key transitional period. We show examples of synergies between the extensive MOSAiC remote sensing observations and numerical modeling, such as estimating the skill of ice drift forecasts and evaluating coupled system modeling. The MOSAiC DN has been proven to enable analysis of local to mesoscale processes in the coupled atmosphere-ice-ocean system and has the potential to improve model parameterizations of important, unresolved processes in the future.
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| 8. |
- Shur, Vladimir, et al.
(författare)
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Modification of the Domain Kinetics in Congruent Lithium Niobate by Proton Exchanged Surface Layers
- 2006
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Konferensbidrag (refereegranskat)abstract
- We have studied the domain kinetics in congruent lithium niobate (CLN) single crystals with different types of the proton exchanged surface layers. The influence of the artificial dielectric layers and the surface gradient of the spontaneous polarization on the domain structure geometry, the shape of the individual domains, and the switching parameters were demonstrated. It was shown that after several cycles of polarization reversal the domain kinetics changes drastically. As a result the domain geometry is defined by spatial distribution of the residual domains existing in the area of domain merging during the previous switching. The role of residual domains increases with the cycle number.
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