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- Ferrand-Drake Del Castillo, Gustav, 1990, et al.
(författare)
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Electrically Switchable Polymer Brushes for Protein Capture and Release in Biological Environments**
- 2022
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Ingår i: Angewandte Chemie - International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 61:22
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Tidskriftsartikel (refereegranskat)abstract
- Interfaces functionalized with polymers are known for providing excellent resistance towards biomolecular adsorption and for their ability to bind high amounts of protein while preserving their structure. However, making an interface that switches between these two states has proven challenging and concepts to date rely on changes in the physiochemical environment, which is static in biological systems. Here we present the first interface that can be electrically switched between a high-capacity (>1 μg cm−2) multilayer protein binding state and a completely non-fouling state (no detectable adsorption). Switching is possible over multiple cycles without any regeneration. Importantly, switching works even when the interface is in direct contact with biological fluids and a buffered environment. The technology offers many applications such as zero fouling on demand, patterning or separation of proteins as well as controlled release of biologics in a physiological environment, showing high potential for future drug delivery in vivo.
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| 2. |
- Kaun, Anne, 1983-, et al.
(författare)
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Political Agency at the Digital Crossroads?
- 2016
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Ingår i: Media and Communication. - : Cogitatio Press. - 2183-2439. ; 4:4, s. 1-7
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Tidskriftsartikel (refereegranskat)abstract
- This thematic issue presents the outcome of the 2015 ECREA Communication and Democracy Section Conference “Political Agency in the Digital Age” that was held at the Copenhagen Business School in Denmark. It problematizes changes in the configurations of political agency in the context of digital media. The articles represent a shift from an exclusive focus on political elites to the interrelation between institutionalised politics and political processes in other societal spheres in the field of media and politics research. Political agency as the main notion of the thematic issue draws attention at the (media) practices through which social actors reproduce, reorganise and challenge politics. At the same time, the issue poses questions about the structures—economic, political and social—that allow for, define and also limit these practices. The contributions gathered here suggest an understanding of agency as constituted through the use of knowledge and resources, themselves embedded within structural contexts; at the same time, agency is transformative of the structures within which it is embedded by making use of knowledge and resources in creative and often radical ways. In that context the development of digital media marks a rupture or critical juncture that allows and requires a rethinking of conditions of political agency. Accordingly the contributions critically scrutinize the role of digital media moving beyond celebratory accounts of democratizing potential of digital media. The rethinking of the grammar of political agency is at the heart of this thematic issue.
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