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- Esmaily, Sorosh, et al.
(författare)
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Patient Outcomes after Heart Transplantation in Sweden between 1988 and 2017: Continuous Improvement in Survival.
- 2020
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Ingår i: The Journal of heart and lung transplantation. 39 (4), S284. - : Elsevier BV. - 1557-3117 .- 1053-2498.
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Konferensbidrag (refereegranskat)abstract
- To investigate the survival of heart transplant (HTx) recipients during different time periods in Sweden. We hypothesized that the survival for HTx recipients has improved following advancements in the management of these patients.Data was obtained through the database of the organ exchange organization Scandiatransplant. All patients who underwent HTx in Sweden between Jan 1988 and Dec 2017 were included. Patients were divided into five cohorts of six-year periods each.A total of 1137 HTx recipients were included. Main causes of transplantation were dilated cardiomyopathy (44 %) and ischemic heart disease (18 %). Retransplantation constituted a small portion of the overall total (2 %). The cohorts were similar in terms of age and gender, while later cohorts had higher BMI, lower GFR and longer ischemia time (Tab. 1). The later cohorts received organs from older donors (Tab. 1). The amount of heart transplantations performed in Sweden has increased with time (Tab. 1). Log-rank test comparing the survival curves was able to show improved survival during later eras (Fig. 1).Survival among HTx recipients has significantly improved in Sweden over time, despite less favorable recipients and donor characteristics. This was related to both reduced postoperative mortality and also improved long-time survival.
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- Kohli, S, et al.
(författare)
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Childhood leukaemia in areas with different radon levels : A spatial and temporal analysis using GIS
- 2000
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Ingår i: Journal of Epidemiology and Community Health. - : BMJ. - 0143-005X .- 1470-2738. ; 54:11, s. 822-826
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Tidskriftsartikel (refereegranskat)abstract
- Objectives-To evaluate the relation between exposure to ground radon levels and leukaemia among children using existing population and disease registers. Design-Ecological correlation study. Setting-The county of Ostergotland in Sweden. Methods-Every child born in the county between 1979 and 1992 was mapped to the property centroid coordinates by linking addresses in the population and property registers. Population maps were overlaid with radon maps and exposure at birth and each subsequent year was quantified as high, normal, low or unknown. This was analysed with data from the tumour registry. Standardised mortality ratios (SMRs) were calculated using the age and sex specific rates for Sweden for the year 1995. Results-90 malignancies occurred among 53 146 children (498 887 person years) who formed the study population. SMRs for acute lymphatic leukemia (ALL) among children born in high, normal and low risk areas were 1.43, 1.17 and 0.25 respectively. The relative risk for the normal risk group and high risk group as compared with the low risk group was 4.64 (95% CI 1.29, 28.26) and 5.67 (95% CI 1.06, 42.27). The association between ALL and continued residence at normal or high risk areas showed a similar trend. No association between radon risk levels and any other malignancy was seen. Conclusion-Children born in and staying at areas where the risk from ground radon has been classified as low are less likely to develop ALL than those born in areas classified as normal and high risk.
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- Valdimarsson, T, et al.
(författare)
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Three years' follow-up of bone density in adult coeliac disease : Significance of secondary hyperparathyroidism
- 2000
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Ingår i: Scandinavian Journal of Gastroenterology. - 0036-5521 .- 1502-7708. ; 35:3, s. 274-280
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Tidskriftsartikel (refereegranskat)abstract
- Background: The mechanisms of disturbances in bone mineral density (BMD) in coeliac disease are not completely understood. The aim of this prospective study was to investigate the possible significance of secondary hyperparathyroidism (SHPT) with regard to BMD in patients with untreated coeliac disease. Methods: One hundred and five adult patients with untreated coeliac disease were examined for BMD and serum parathyroid hormone (PTH) concentration. BMD in the hip, lumbar spine, and forearm were examined up to 3 years after the introduction of a gluten-free diet. Results: SHPT was found in 27% (28 of 105) of the patients. In patients with SHPT serum levels of 25- hydroxy-vitamin D were lower and those of alkaline phosphatase higher than in patients with normal PTH, but ionized serum calcium did not differ between the two groups. BMD was more severely reduced in patients with SHPT. Although the BMD increment was more rapid in patients with than in those without SPTH, only in the latter group did mean BMD became normal after 1-3 years on a gluten-free diet (GFD). After 3 years on a GFD more than half of the patients with initial SHPT still had low BMD in both the hip and the forearm. Furthermore, in patients with SHPT the intestinal mucosa more often remained atrophic at the 1-year follow-up, despite good compliance with the diet. Conclusions: Low BMD in patients with untreated coeliac disease is often associated with SHPT. After 3 years on a GFD the BMD remains low only in patients with initial SHPT. We therefore suggest that PTH should be measured when the diagnosis of coeliac disease is made, as an indicator of more serious intestinal disorder and complicating bone disease.
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- Zackrisson, Ulf, et al.
(författare)
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Alterations of follicular microcirculation and apex structure during ovulation in the rat.
- 2011
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Ingår i: European journal of obstetrics, gynecology, and reproductive biology. - : Elsevier BV. - 1872-7654 .- 0301-2115.
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: We utilized methods for intravital microscopy and microcirculation measurements to study changes during ovulation. STUDY DESIGN: Immature gonadotrophin-primed rats were laparotomized and one ovary was examined for morphological alterations during a 3h period (covering a period from 1h before to 27h after hCG) through water-immersion lenses (maximum magnification 812×). Microcirculatory blood flow was assessed by measurements of blood cell velocity and laser Doppler flowmetry. RESULTS: Follicular hyperaemia was observed 30min after hCG and then vasomotion was observed. A gradual decline of apical blood flow was seen, which later was associated with an avascular area over the top of the apex. Cells from the surface over the follicular apex were then detached from the exterior of the follicle and this phenomenon was initiated more than one hour prior to follicular rupture. The subsequent structural alterations varied with or without formation of a cone over the stigma. In ovulations with a stigma-cone, a translucent, irregular mass formed over the stigma. Prior to follicular rupture, granulosa cells and follicular fluid were extruded from the follicular cavity at a velocity of around 70μm/s. Occasionally, intra-antral haemorrhage occurred prior to or during follicular rupture. CONCLUSION: Characteristic features of ovulation in the rat are microcirculatory vasomotion, gradual formation of apical avascular area, specific changes of the stigma, and extrusion of the oocyte-granulosa cell complex with or without haemorrhage.
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