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| 2. |
- Gorchs, L, et al.
(författare)
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Chemokine Receptor Expression on T Cells Is Modulated by CAFs and Chemokines Affect the Spatial Distribution of T Cells in Pancreatic Tumors
- 2022
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 14:15
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Tidskriftsartikel (refereegranskat)abstract
- The accumulation of T cells is associated with a better prognosis in pancreatic cancer. However, the immunosuppressive tumor microenvironment, largely composed by cancer-associated fibroblasts (CAFs), can prevent T cells from reaching the tumor nests. We examined how human CAFs modulated chemokine receptors known to be associated with T cell trafficking, CXCR3 and CCR5, and T cell exclusion, CXCR4. CAFs decreased the expression of CXCR3 and CCR5 but increased CXCR4 expression in both 2D and 3D cultures, affecting the migratory capacity of T cells towards CXCL10. An immunohistochemistry analysis showed that very few T cells were found in the tumor nests. Within the stroma, CD8+ T cells were localized more distantly from the malignant cells whereas CD4+ T cells were more equally distributed. Tumor tissues with a high production of chemokines were associated with less T cell infiltration when the whole tissue was analyzed. However, when the spatial localization of CD8+ T cells within the tissue was taken into account, levels of CXCR3 ligands and the CCR5 ligand CCL8 showed a positive association with a high relative T cell infiltration in tumor-rich areas. Thus, CXCR3 ligands could mediate T cell trafficking but CAFs could prevent T cells from reaching the malignant cells.
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| 4. |
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| 5. |
- Lindberg, CF, et al.
(författare)
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Adaptive control of external carbon flow rate in an activated sludge process
- 1996
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Ingår i: WATER SCIENCE AND TECHNOLOGY. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0273-1223. ; 34:3-4, s. 173-180
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- In this study an adaptive carbon flow rate controller is applied to a pre-denitrifying pilot-scale plant. The goal of the control strategy is to maintain a low nitrate concentration in the anoxic zone by controlling the external flow rate of the carbon so
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| 6. |
- Lindberg, CF, et al.
(författare)
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Estimation of the respiration rate and oxygen transfer function utilizing a slow DO sensor
- 1996
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Ingår i: WATER SCIENCE AND TECHNOLOGY. - : PERGAMON-ELSEVIER SCIENCE LTD. ; 33:1, s. 325-333
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Recension (övrigt vetenskapligt/konstnärligt)abstract
- In this paper a software sensor for estimating the respiration rate and the nonlinear oxygen transfer function K(L)a is presented. The respiration rate and the oxygen transfer function were estimated from measurements of the dissolved oxygen concentration
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| 7. |
- Lindberg, CF
(författare)
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Multivariable modeling and control of an activated sludge process
- 1998
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Ingår i: WATER SCIENCE AND TECHNOLOGY. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0273-1223. ; 37:12, s. 149-156
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- This paper contains two contributions. First it is shown, in a simulation study using the IAWQ model, that a linear multivariable time-invariant state-space model can be used to predict the ammonium and nitrate concentration in the last aerated zone in a
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| 8. |
- Lindberg, CF, et al.
(författare)
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Nonlinear and set-point control of the dissolved oxygen concentration in an activated sludge process
- 1996
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Ingår i: WATER SCIENCE AND TECHNOLOGY. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0273-1223. ; 34:3-4, s. 135-142
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Control of the dissolved oxygen concentration (DO) in an activated sludge process is of considerable importance because of economy and process efficiency. A strategy for designing a nonlinear DO controller was developed. The basic idea was to take the non
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