| 1. |
- Engert, Andreas, et al.
(författare)
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The European Hematology Association Roadmap for European Hematology Research : a consensus document
- 2016
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Ingår i: Haematologica. - Pavia, Italy : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 101:2, s. 115-208
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Tidskriftsartikel (refereegranskat)abstract
- The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at (sic)23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.
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| 2. |
- Aad, G, et al.
(författare)
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- 2015
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swepub:Mat__t
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| 3. |
- Asselbergs, Folkert W., et al.
(författare)
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Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci
- 2012
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Ingår i: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297. ; 91:5, s. 823-838
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWASs) have identified many SNPs underlying variations in plasma-lipid levels. We explore whether additional loci associated with plasma-lipid phenotypes, such as high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TGs), can be identified by a dense gene-centric approach. Our meta-analysis of 32 studies in 66,240 individuals of European ancestry was based on the custom similar to 50,000 SNP genotyping array (the ITMAT-Broad-CARe array) covering similar to 2,000 candidate genes. SNP-lipid associations were replicated either in a cohort comprising an additional 24,736 samples or within the Global Lipid Genetic Consortium. We identified four, six, ten, and four unreported SNPs in established lipid genes for HDL-C, LDL-C, TC, and TGs, respectively. We also identified several lipid-related SNPs in previously unreported genes: DGAT2, HCAR2, GPIHBP1, PPARG, and FTO for HDL-C; SOCS3, APOH, SPTY2D1, BRCA2, and VLDLR for LDL-C; SOCS3, UGT1A1, BRCA2, UBE3B, FCGR2A, CHUK, and INSIG2 for TC; and SERPINF2, C4B, GCK, GATA4, INSR, and LPAL2 for TGs. The proportion of explained phenotypic variance in the subset of studies providing individual-level data was 9.9% for HDL-C, 9.5% for LDL-C, 10.3% for TC, and 8.0% for TGs. This large meta-analysis of lipid phenotypes with the use of a dense gene-centric approach identified multiple SNPs not previously described in established lipid genes and several previously unknown loci. The explained phenotypic variance from this approach was comparable to that from a meta-analysis of GWAS data, suggesting that a focused genotyping approach can further increase the understanding of heritability of plasma lipids.
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| 4. |
- Berger, Cyrille, 1982-, et al.
(författare)
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DSeg : Détection directe de segments dans une image
- 2010
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Ingår i: 17ème congrès francophone AFRIF-AFIA Reconnaissance des Formes et Intelligence Artificielle (RFIA).
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Konferensbidrag (refereegranskat)abstract
- Cet article présente une approche ``model-driven'' pour détecter des segmentsde droite dans une image. L'approche détecte les segments de manièreincrémentale sur la base du gradient de l'image, en exploitant un filtre deKalman linéaire qui estime les paramètres de la droite support des segments etles variances associées. Les algorithmes sont rapides et robustes au bruit etaux variations d'illumination de la scène perçue, ils permettent de détecterdes segments plus longs que les approches existantes guidées par les données(``data-driven''), et ils ne nécessitent pas de délicate détermination deparamètres. Des résultats avec différentes conditions d'éclairage et descomparaisons avec les approches existantes sont présentés.
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| 5. |
- Berger, Cyrille, 1982-, et al.
(författare)
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DSeg: Direct Line Segments Detection
- 2023
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This paper presents a model-driven approach to detect image line segments. The approach incrementally detects segments on the gradient image using a linear Kalman filter that estimates the supporting line parameters and their associated variances. The algorithm is fast and robust with respect to image noise and illumination variations, it allows the detection of longer line segments than data-driven approaches, and does not require any tedious parameters tuning. An extension of the algorithm that exploits a pyramidal approach to enhance the quality of results is proposed. Results with varying scene illumination and comparisons to classic existing approaches are presented.
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| 6. |
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| 7. |
- Berger, Cyrille, 1982-
(författare)
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Perception de la géométrie de l'environment pour la navigation autonome
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Le but de la recherche en robotique mobile est de donner aux robots la capacité d'accomplir des missions dans un environnement qui n'est pas parfaitement connu. Mission, qui consiste en l'exécution d'un certain nombre d'actions élémentaires (déplacement, manipulation d'objets...) et qui nécessite une localisation précise, ainsi que la construction d'un bon modèle géométrique de l'environnement, a partir de l'exploitation de ses propres capteurs, des capteurs externes, de l'information provenant d'autres robots et de modèle existant, par exemple d'un système d'information géographique. L'information commune est la géométrie de l'environnement. La première partie du manuscrit couvre les différentes méthodes d'extraction de l'information géométrique. La seconde partie présente la création d'un modèle géométrique en utilisant un graphe, ainsi qu'une méthode pour extraire de l'information du graphe et permettre au robot de se localiser dans l'environnement.
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| 8. |
- Berger, Cyrille, 1982-, et al.
(författare)
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Using planar facets for stereovision SLAM
- 2008
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Ingår i: Proceedings of the IEEE/RSJ International Conference on Intelligent RObots and Systems (IROS). - : IEEE conference proceedings. - 9781424420575 ; , s. 1606-1611
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Konferensbidrag (refereegranskat)abstract
- In the context of stereovision SLAM, we propose a way to enrich the landmark models. Vision-based SLAM approaches usually rely on interest points associated to a point in the Cartesian space: by adjoining oriented planar patches (if they are present in the environment), we augment the landmark description with an oriented frame. Thanks to this additional information, the robot pose is fully observable with the perception of a single landmark, and the knowledge of the patches orientation helps the matching of landmarks. The paper depicts the chosen landmark model, the way to extract and match them, and presents some SLAM results obtained with such landmarks.
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| 9. |
- Elena, J. W., et al.
(författare)
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Diabetes and risk of pancreatic cancer : a pooled analysis from the pancreatic cancer cohort consortium
- 2013
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Ingår i: Cancer Causes and Control. - : Springer Science and Business Media LLC. - 0957-5243 .- 1573-7225. ; 24:1, s. 13-25
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Diabetes is a suspected risk factor for pancreatic cancer, but questions remain about whether it is a risk factor or a result of the disease. This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic cancer cohort consortium (PanScan). Methods: The pooled data included 1,621 pancreatic adenocarcinoma cases and 1,719 matched controls from twelve cohorts using a nested case-control study design. Subjects who were diagnosed with diabetes near the time (<2 years) of pancreatic cancer diagnosis were excluded from all analyses. All analyses were adjusted for age, race, gender, study, alcohol use, smoking, BMI, and family history of pancreatic cancer. Results: Self-reported diabetes was associated with a forty percent increased risk of pancreatic cancer (OR = 1.40, 95 % CI: 1.07, 1.84). The association differed by duration of diabetes; risk was highest for those with a duration of 2-8 years (OR = 1.79, 95 % CI: 1.25, 2.55); there was no association for those with 9+ years of diabetes (OR = 1.02, 95 % CI: 0.68, 1.52). Conclusions: These findings provide support for a relationship between diabetes and pancreatic cancer risk. The absence of association in those with the longest duration of diabetes may reflect hypoinsulinemia and warrants further investigation.
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| 10. |
- Ernst, Yolandi, et al.
(författare)
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The African Regional Greenhouse Gases Budget (2010–2019)
- 2024
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Ingår i: Global Biogeochemical Cycles. - 0886-6236. ; 38:4
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Tidskriftsartikel (refereegranskat)abstract
- As part of the REgional Carbon Cycle Assessment and Processes Phase 2 (RECCAP2) project, we developed a comprehensive African Greenhouse gases (GHG) budget covering 2000 to 2019 (RECCAP1 and RECCAP2 time periods), and assessed uncertainties and trends over time. We compared bottom-up process-based models, data-driven remotely sensed products, and national GHG inventories with top-down atmospheric inversions, accounting also for lateral fluxes. We incorporated emission estimates derived from novel methodologies for termites, herbivores, and fire, which are particularly important in Africa. We further constrained global woody biomass change products with high-quality regional observations. During the RECCAP2 period, Africa's carbon sink capacity is decreasing, with net ecosystem exchange switching from a small sink of −0.61 ± 0.58 PgC yr−1 in RECCAP1 to a small source in RECCAP2 at 0.16 (−0.52/1.36) PgC yr−1. Net CO2 emissions estimated from bottom-up approaches were 1.6 (−0.9/5.8) PgCO2 yr−1, net CH4 were 77 (56.4/93.9) TgCH4 yr−1 and net N2O were 2.9 (1.4/4.9) TgN2O yr−1. Top-down atmospheric inversions showed similar trends. Land Use Change emissions increased, representing one of the largest contributions at 1.7 (0.8/2.7) PgCO2eq yr−1 to the African GHG budget and almost similar to emissions from fossil fuels at 1.74 (1.53/1.96) PgCO2eq yr−1, which also increased from RECCAP1. Additionally, wildfire emissions decreased, while fuelwood burning increased. For most component fluxes, uncertainty is large, highlighting the need for increased efforts to address Africa-specific data gaps. However, for RECCAP2, we improved our overall understanding of many of the important components of the African GHG budget that will assist to inform climate policy and action.
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