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- Arendt, Maja Louise, et al.
(författare)
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The ABCC4 gene is associated with pyometra in golden retriever dogs
- 2021
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- Pyometra is one of the most common diseases in female dogs, presenting as purulent inflammation and bacterial infection of the uterus. On average 20% of intact female dogs are affected before 10 years of age, a proportion that varies greatly between breeds (3-66%). The clear breed predisposition suggests that genetic risk factors are involved in disease development. To identify genetic risk factors associated with the disease, we performed a genome-wide association study (GWAS) in golden retrievers, a breed with increased risk of developing pyometra (risk ratio: 3.3). We applied a mixed model approach comparing 98 cases, and 96 healthy controls and identified an associated locus on chromosome 22 (p = 1.2 x 10(-6), passing Bonferroni corrected significance). This locus contained five significantly associated SNPs positioned within introns of the ATP-binding cassette transporter 4 (ABCC4) gene. This gene encodes a transmembrane transporter that is important for prostaglandin transport. Next generation sequencing and genotyping of cases and controls subsequently identified four missense SNPs within the ABCC4 gene. One missense SNP at chr22:45,893,198 (p.Met787Val) showed complete linkage disequilibrium with the associated GWAS SNPs suggesting a potential role in disease development. Another locus on chromosome 18 overlapping the TESMIN gene, is also potentially implicated in the development of the disease.
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- Bergknut, Niklas, et al.
(författare)
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Incidence of intervertebral disk degeneration-related diseases and associated mortality rates in dogs
- 2012
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Ingår i: Journal of the American Veterinary Medical Association. - : American Veterinary Medical Association (AVMA). - 0003-1488. ; 240, s. 1300-1309
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Tidskriftsartikel (refereegranskat)abstract
- Conclusions and Clinical Relevance-Differences in incidence rates among various breeds suggested a genetic involvement. Knowledge of the distribution of IVD degeneration related diseases among dogs of various breeds and ages may facilitate early diagnosis and preemptive treatments in patients at risk for developing these diseases. (J Am Vet Med Assoc 2012;240:1300-1309)
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