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- Pfarr, C. M., et al.
(författare)
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Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras
- 1994
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Ingår i: Cell. - : Cell Press. - 0092-8674 .- 1097-4172. ; 76:4, s. 747-760
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Tidskriftsartikel (refereegranskat)abstract
- As NIH 3T3 fibroblasts become quiescent, the level of c-Jun protein decreases while JunD accumulates. When resting cells are stimulated with fresh serum, nuclear-localized JunD is rapidly degraded, followed by resynthesis of both c-Jun and JunD later in G1. Overexpression of JunD results in slower growth and an increase in the percentage of cells in G0/G1 while c-Jun overexpression produces larger S/G2 and M phase populations. In addition, JunD partially suppresses transformation by an activated ras gene whereas c-Jun cooperates with ras to transform cells. These data indicate that two closely related transcription factors can function in an opposing manner.
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- Roizard, X., et al.
(författare)
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Friction behavior of ferritic stainless steel in a strongly diluted alcohol solution of alkylphosphonic acid
- 2018
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Ingår i: Tribology International. - : Elsevier BV. - 0301-679X .- 1879-2464. ; 118, s. 465-473
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Tidskriftsartikel (refereegranskat)abstract
- The present study investigates the potential for using this more environmentally friendly lubrication at an industrial scale forming of stainless steel. Against this background we analyze the characteristics of the tribofilm formed on a stainless steel surface during sliding experiments performed in solutions containing alkylphosphonic acids, under various contact conditions. Specific tribological tests were designed to analyze the dynamics of the lubricating mechanism. It was found that both the grafting of molecules and the transformation of these into an efficient tribofihn are quick processes, irrespective of substrate roughness or contact pressure, systematically leading to low friction coefficient.
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- Roizard, X., et al.
(författare)
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Insights into sliding wear and friction behavior of copper in ethanol containing alkylphosphonic acid molecules
- 2016
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Ingår i: Tribology International. - : Elsevier BV. - 0301-679X .- 1879-2464. ; 96, s. 141-148
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Tidskriftsartikel (refereegranskat)abstract
- In this work, the friction and wear behavior of bare copper was investigated for the first time under lubricated sliding conditions in diluted ethanol solutions of butylhosphonic (C4P), octylphosphonic (C8P), dodecylphosphonic (C12P), and hexadecylphosphonic (C16P) acids. The technique aims towards a more environmentally friendly lubrication to be used in shaping of copper sheets. Bare copper samples were subjected to unidirectional sliding using a tribometer with ball-on-disk contact geometry. Copper substrates (20 mm2×1 mm) were run against 100Cr6 ∅10 mm ball bearing counterbodies. All tests were conducted using the same sliding conditions with a normal load of 10 N, tangential velocity of 0.01 m/s, at room temperature of 20 °C. Worn surfaces were analyzed by Scanning Electron Microscopy, Optical Microscopy and White Light Interference Profilometry. When comparing to sliding tests in the pure ethanol solvent, significant decreases in terms of wear track dimensions, transferred material on the ball and friction coefficients are observed when active molecules are present in the solution. These form protective tribofilms exhibiting lubricating and anti-wear properties. Deeper studies on the tribological behavior of copper in C4P solution show that both low friction and low transfer of work material to the ball prevail in a specific range of low molecule concentration (5×10-4 M; 25×10-4 M). Even if the molecules are introduced during the test, after a few cycles, the tribological behavior improves, regardless of both friction level and copper surface degradation. Finally, specific friction tests were performed to further investigate the mechanisms. It was found that two mechanisms are involved; firstly molecules grafting onto the surface directly reduces friction, and secondly transformation of these grafted molecules into a tribofilm during the first mechanical contact cycles reduces it even further.
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