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- Boulo, S., et al.
(author)
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First amyloid β1-42 certified reference material for re-calibrating commercial immunoassays
- 2020
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In: Alzheimer's and Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 16:11, s. 1493-1503
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Journal article (peer-reviewed)abstract
- Introduction: Reference materials based on human cerebrospinal fluid were certified for the mass concentration of amyloid beta (Aβ)1-42 (Aβ42). They are intended to be used to calibrate diagnostic assays for Aβ42. Methods: The three certified reference materials (CRMs), ERM-DA480/IFCC, ERM-DA481/IFCC and ERM-DA482/IFCC, were prepared at three concentration levels and characterized using isotope dilution mass spectrometry methods. Roche, EUROIMMUN, and Fujirebio used the three CRMs to re-calibrate their immunoassays. Results: The certified Aβ42 mass concentrations in ERM-DA480/IFCC, ERM-DA481/IFCC, and ERM-DA482/IFCC are 0.45, 0.72, and 1.22μg/L, respectively, with expanded uncertainties (k=2) of 0.07, 0.11, and 0.18μg/L, respectively. Before re-calibration, a good correlation (Pearson's r>0.97), yet large biases, were observed between results from different commercial assays. After re-calibration the between-assay bias was reduced to<5%. Discussion: The Aβ42 CRMs can ensure the equivalence of results between methods and across platforms for the measurement of Aβ42. © 2020 the Alzheimer's Association
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| 3. |
- Kenalemang-Palm, Lame M., 1991-
(author)
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"It takes a long time to become young" : A critical feminist intersectional study of Vogue’s Non-Issue
- 2023
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In: European Journal of Cultural Studies. - : Sage Publications. - 1367-5494 .- 1460-3551.
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Journal article (peer-reviewed)abstract
- Older female celebrities are increasingly visible in popular media culture, but what kinds of representations are being offered? By deploying a feminist intersectional perspective and adopting Multimodal Critical Discourse Analysis (MCDA), this article interrogates how British Vogue’s Non-Issue communicates ideas and values about ageing and how the magazine constructs discourses through which women’s ageing is understood. The analysis shows that the Non-Issue represents older women as radical and empowered subjects. The rhetoric of freedom and choice, central to postfeminism, is prominent in the magazine and aligns with neoliberal discourses of successful ageing. Such discourses encourage women to confine themselves to never-ending, rigid forms of self-surveillance, self-monitoring and self-disciplining that ultimately subject the older female body to a ‘new’ set of bodily inscriptions and prescriptions that reinforce patriarchal standards of beauty. These standards of beauty are, however, challenged in the magazine through a recuperated do-it-yourself discourse of punk spirit rebellion that works to commodify women’s empowerment, yet still reduces women to how they look.
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| 4. |
- Kenalemang-Palm, Lame M., 1991-, et al.
(author)
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The scientifization of “green” anti-ageing cosmetics in online marketing : a multimodal critical discourse analysis
- 2023
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In: Social Semiotics. - : Routledge. - 1035-0330 .- 1470-1219. ; 33:5, s. 1026-1045
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Journal article (peer-reviewed)abstract
- This paper examines the marketing of trending green cosmetic products containing natural ingredients and coming with claims to keep skin health-enhancing and age-defying benefits. This is fostered by the growing importance of successful ageing and the neoliberal self-care agenda. Adopting the notion of "integrated design" from Multimodal Critical Discourse Analysis (MCDA), this paper looks at the communicative affordances of the web and how marketers of "green" cosmetics connect these to science. The analysis shows that the integrated design of the webpages allows cosmetic companies to connote science while glossing over significant details, leaving causalities, classifications, and processes unspecified. This marketing frames fighting the "look" of ageing as a moral and ethical consumption choice. Such choices relate to self-care regimes of a "successful" neoliberal citizenship.
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| 5. |
- Pannee, Josef, 1979, et al.
(author)
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Round robin test on quantification of amyloid-β 1-42 in cerebrospinal fluid by mass spectrometry.
- 2016
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association. - : Wiley. - 1552-5279. ; 12:1, s. 55-59
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Journal article (peer-reviewed)abstract
- Cerebrospinal fluid (CSF) amyloid-β 1-42 (Aβ42) is an important biomarker for Alzheimer's disease, both in diagnostics and to monitor disease-modifying therapies. However, there is a great need for standardization of methods used for quantification. To overcome problems associated with immunoassays, liquid chromatography-tandem mass spectrometry (LC-MS/MS) has emerged as a critical orthogonal alternative.
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