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- Thomas, HS, et al.
(författare)
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- 2019
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swepub:Mat__t
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| 2. |
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| 3. |
- Drake, TM, et al.
(författare)
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Surgical site infection after gastrointestinal surgery in children: an international, multicentre, prospective cohort study
- 2020
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Ingår i: BMJ global health. - : BMJ. - 2059-7908. ; 5:12
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Tidskriftsartikel (refereegranskat)abstract
- Surgical site infection (SSI) is one of the most common healthcare-associated infections (HAIs). However, there is a lack of data available about SSI in children worldwide, especially from low-income and middle-income countries. This study aimed to estimate the incidence of SSI in children and associations between SSI and morbidity across human development settings.MethodsA multicentre, international, prospective, validated cohort study of children aged under 16 years undergoing clean-contaminated, contaminated or dirty gastrointestinal surgery. Any hospital in the world providing paediatric surgery was eligible to contribute data between January and July 2016. The primary outcome was the incidence of SSI by 30 days. Relationships between explanatory variables and SSI were examined using multilevel logistic regression. Countries were stratified into high development, middle development and low development groups using the United Nations Human Development Index (HDI).ResultsOf 1159 children across 181 hospitals in 51 countries, 523 (45·1%) children were from high HDI, 397 (34·2%) from middle HDI and 239 (20·6%) from low HDI countries. The 30-day SSI rate was 6.3% (33/523) in high HDI, 12·8% (51/397) in middle HDI and 24·7% (59/239) in low HDI countries. SSI was associated with higher incidence of 30-day mortality, intervention, organ-space infection and other HAIs, with the highest rates seen in low HDI countries. Median length of stay in patients who had an SSI was longer (7.0 days), compared with 3.0 days in patients who did not have an SSI. Use of laparoscopy was associated with significantly lower SSI rates, even after accounting for HDI.ConclusionThe odds of SSI in children is nearly four times greater in low HDI compared with high HDI countries. Policies to reduce SSI should be prioritised as part of the wider global agenda.
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| 5. |
- Koposov, Sergey E., et al.
(författare)
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Kinematics and chemistry of recently discovered Reticulum 2 and Horologium 1 dwarf galaxies
- 2015
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 811:1
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Tidskriftsartikel (refereegranskat)abstract
- We report on VLT/GIRAFFE spectra of stars in two recently discovered ultra-faint satellites, Reticulum 2 and Horologium 1, obtained as part of the Gaia-ESO Survey. We identify 18 members in Reticulum 2 and five in Horologium 1. We find Reticulum 2 to have a velocity dispersion of 3.22(-0.49)(+1.64) km s(-1) , implying a mass-to-light ratio (M/L) of similar to 500. The mean metallicity of Reticulum 2 is [Fe/H] = -2.46, with an intrinsic dispersion of similar to 0.3 dex and alpha-enhancement of similar to 0.4 dex. We conclude that Reticulum 2 is a dwarf galaxy. We also report on the serendipitous discovery of four stars in a previously unknown stellar substructure near Reticulum 2 with [Fe/H] similar to -2 and V-hel similar to 220 km s(-1), far from the systemic velocity of Reticulum 2. For Horologium 1 we infer a velocity dispersion of sigma (V) = 4.9(-0.9)(+2.8) km s(-1) and a M/L ratio of similar to 600, leading us to conclude that Horologium 1 is also a dwarf galaxy. Horologium 1 is slightly more metal-poor than Reticulum 2 ([Fe/H] = -2.76) and is similarly alpha-enhanced: [alpha/Fe] similar to 0.3 dex with a significant spread of metallicities of 0.17 dex. The line-of-sight velocity of Reticulum 2 is offset by 100 km s(-1) from the prediction of the orbital velocity of the Large Magellanic Cloud (LMC), thus making its association with the Cloud uncertain. However, at the location of Horologium 1, both the backward-integrated orbit of the LMC and its halo are predicted to have radial velocities similar to that of the dwarf. Therefore, it is possible that Horologium 1 is or once was a member of the Magellanic family.
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| 6. |
- Opel, Michael, et al.
(författare)
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Genome-Wide Studies of Histone Demethylation Catalysed by the Fission Yeast Homologues of Mammalian LSD1
- 2007
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 2:4
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Tidskriftsartikel (refereegranskat)abstract
- In order to gain a more global view of the activity of histone demethylases, we report here genome-wide studies of the fission yeast SWIRM and polyamine oxidase (PAO) domain homologues of mammalian LSD1. Consistent with previous work we find that the two S. pombe proteins, which we name Swm1 and Swm2 (after SWIRM1 and SWIRM2), associate together in a complex. However, we find that this complex specifically demethylates lysine 9 in histone H3 (H3K9) and both up-and down-regulates expression of different groups of genes. Using chromatin-immunoprecipitation, to isolate fragments of chromatin containing either H3K4me2 or H3K9me2, and DNA microarray analysis (ChIP-chip), we have studied genome-wide changes in patterns of histone methylation, and their correlation with gene expression, upon deletion of the swm1(+) gene. Using hyper-geometric probability comparisons we uncover genetic links between lysine-specific demethylases, the histone deacetylase Clr6, and the chromatin remodeller Hrp1. The data presented here demonstrate that in fission yeast the SWIRM/PAO domain proteins Swm1 and Swm2 are associated in complexes that can remove methyl groups from lysine 9 methylated histone H3. In vitro, we show that bacterially expressed Swm1 also possesses lysine 9 demethylase activity. In vivo, loss of Swm1 increases the global levels of both H3K9me2 and H3K4me2. A significant accumulation of H3K4me2 is observed at genes that are up-regulated in a swm1 deletion strain. In addition, H3K9me2 accumulates at some genes known to be direct Swm1/2 targets that are down-regulated in the swm1 Delta strain. The in vivo data indicate that Swm1 acts in concert with the HDAC Clr6 and the chromatin remodeller Hrp1 to repress gene expression. In addition, our in vitro analyses suggest that the H3K9 demethylase activity requires an unidentified post-translational modification to allow it to act. Thus, our results highlight complex interactions between histone demethylase, deacetylase and chromatin remodelling activities in the regulation of gene expression.
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| 7. |
- Commissaris, Dianne A. C. M., et al.
(författare)
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Interventions to reduce sedentary behavior and increase physical activity during productive work : a systematic review
- 2016
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Ingår i: Scandinavian Journal of Work, Environment and Health. - : Scandinavian Journal of Work, Environment and Health. - 0355-3140 .- 1795-990X. ; 42:3, s. 181-191
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Forskningsöversikt (refereegranskat)abstract
- Objectives: Many current jobs are characterized by sedentary behaviour (SB) and lack of physical activity (PA). Interventions addressing SB and PA at the workplace may benefit workers’ health. The present review is the first to focus on the effectiveness of interventions implemented during productive work with the intention to change workers’ SB and/or PA while working.Methods: Scopus was searched for articles published from 1992 until March 12, 2015. Relevant studies were evaluated using the Quality Assessment Tool for Quantitative Studies and summarized in a best-evidence synthesis.Results: 40 studies describing 41 interventions were included and organized into three categories: alternative workstations (20), interventions promoting stair use (11) and personalized behavioural interventions (10). Strong evidence was found for alternative workstations leading to positive effects on overall SB, while evidence was conflicting for effects on SB and PA at work, overall PA, and work performance. Evidence was moderate for alternative workstations to have no effect on hemodynamics and cardiorespiratory fitness. Stair use promotion interventions were found to increase PA at work, while personalized behavioural interventions increased overall PA; both with moderate evidence. Personalized behavioural interventions were found to have no effect on anthropometric measures (moderate evidence). Regarding work performance and lipid and metabolic profiles, evidence was either conflicting or insufficient.Conclusions: Current evidence supports that introduction of alternative workstations may have positive effects on overall PA and SB, likely without reducing work performance, while the long-term health effects of all three reviewed categories of interventions remain to be established.
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