| 1. |
-
- 2019
-
Tidskriftsartikel (refereegranskat)
|
|
| 2. |
- Botvinik-Nezer, Rotem, et al.
(författare)
-
Variability in the analysis of a single neuroimaging dataset by many teams
- 2020
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 582, s. 84-88
-
Tidskriftsartikel (refereegranskat)abstract
- Data analysis workflows in many scientific domains have become increasingly complex and flexible. Here we assess the effect of this flexibility on the results of functional magnetic resonance imaging by asking 70 independent teams to analyse the same dataset, testing the same 9 ex-ante hypotheses(1). The flexibility of analytical approaches is exemplified by the fact that no two teams chose identical workflows to analyse the data. This flexibility resulted in sizeable variation in the results of hypothesis tests, even for teams whose statistical maps were highly correlated at intermediate stages of the analysis pipeline. Variation in reported results was related to several aspects of analysis methodology. Notably, a meta-analytical approach that aggregated information across teams yielded a significant consensus in activated regions. Furthermore, prediction markets of researchers in the field revealed an overestimation of the likelihood of significant findings, even by researchers with direct knowledge of the dataset(2-5). Our findings show that analytical flexibility can have substantial effects on scientific conclusions, and identify factors that may be related to variability in the analysis of functional magnetic resonance imaging. The results emphasize the importance of validating and sharing complex analysis workflows, and demonstrate the need for performing and reporting multiple analyses of the same data. Potential approaches that could be used to mitigate issues related to analytical variability are discussed. The results obtained by seventy different teams analysing the same functional magnetic resonance imaging dataset show substantial variation, highlighting the influence of analytical choices and the importance of sharing workflows publicly and performing multiple analyses.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- Andersson, Camilla, 1979-, et al.
(författare)
-
Interannual variation and trends in air pollution over Europe due to climate variability during 1958–2001 simulated with a regional CTM coupled to the ERA40 reanalysis
- 2007
-
Ingår i: Tellus. Series B, Chemical and physical meteorology. - Stockholm : Tellus. - 0280-6509 .- 1600-0889. ; 59, s. 77-98
-
Tidskriftsartikel (refereegranskat)abstract
- A three-dimensional Chemistry Transport Model was used to study the meteorologically induced interannual variability and trends in deposition of sulphur and nitrogen as well as concentrations of surface ozone (O3), nitrogen dioxide (NO2) and particulate matter (PM) and its constituents over Europe during 1958–2001. The model was coupled to the meteorological reanalysis ERA40, produced at the European Centre for Medium-range Weather Forecasts. Emissions and boundary conditions of chemical compounds and PM were kept constant at present levels. The average European interannual variation, due to meteorological variability, ranges from 3% for O3, 5%for NO2, 9% for PM, 6–9% for dry deposition, to about 20% for wet deposition of sulphur and nitrogen. For the period 1979–2001 the trend in ozone, due to climate variability is increasing in central and southwestern Europe and decreasing in northeastern Europe, the trend in NO2 is approximately opposite. The trend in PM is positive in eastern Europe. There are negative trends in wet deposition in southwestern and central Europe and positive trends in dry deposition overall. A bias in ERA40 precipitation could be partly responsible for the trends. The variation and trends need to be considered when interpreting measurements and designing measurement campaigns.
|
|
| 7. |
- Godman, Brian, et al.
(författare)
-
Utilisation Trend of Long-Acting Insulin Analogues including Biosimilars across Europe : Findings and Implications
- 2021
-
Ingår i: BioMed Research International. - : Hindawi Publishing Corporation. - 2314-6133 .- 2314-6141. ; 2021
-
Tidskriftsartikel (refereegranskat)abstract
- Background. Diabetes mellitus rates and associated costs continue to rise across Europe enhancing health authority focus on its management. The risk of complications is enhanced by poor glycaemic control, with long-acting insulin analogues developed to reduce hypoglycaemia and improve patient convenience. There are concerns though with their considerably higher costs, but moderated by reductions in complications and associated costs. Biosimilars can help further reduce costs. However, to date, price reductions for biosimilar insulin glargine appear limited. In addition, the originator company has switched promotional efforts to more concentrated patented formulations to reduce the impact of biosimilars. There are also concerns with different devices between the manufacturers. As a result, there is a need to assess current utilisation rates for insulins, especially long-acting insulin analogues and biosimilars, and the rationale for patterns seen, among multiple European countries to provide future direction.Methodology. Health authority databases are examined to assess utilisation and expenditure patterns for insulins, including biosimilar insulin glargine. Explanations for patterns seen were provided by senior-level personnel.Results. Typically increasing use of long-acting insulin analogues across Europe including both Western and Central and Eastern European countries reflects perceived patient benefits despite higher prices. However, activities by the originator company to switch patients to more concentrated insulin glargine coupled with lowering prices towards biosimilars have limited biosimilar uptake, with biosimilars not currently launched in a minority of European countries. A number of activities were identified to address this. Enhancing the attractiveness of the biosimilar insulin market is essential to encourage other biosimilar manufacturers to enter the market as more long-acting insulin analogues lose their patents to benefit all key stakeholder groups.Conclusions. There are concerns with the availability and use of insulin glargine biosimilars among European countries despite lower costs. This can be addressed.
|
|
| 8. |
- Haddad, Tariq Sami, et al.
(författare)
-
Improving tumor budding reporting in colorectal cancer: a Delphi consensus study
- 2021
-
Ingår i: Virchows Archiv. - : SPRINGER. - 0945-6317 .- 1432-2307. ; 479:3, s. 459-469
-
Tidskriftsartikel (refereegranskat)abstract
- Tumor budding is a long-established independent adverse prognostic marker in colorectal cancer, yet methods for its assessment have varied widely. In an effort to standardize its reporting, a group of experts met in Bern, Switzerland, in 2016 to reach consensus on a single, international, evidence-based method for tumor budding assessment and reporting (International Tumor Budding Consensus Conference [ITBCC]). Tumor budding assessment using the ITBCC criteria has been validated in large cohorts of cancer patients and incorporated into several international colorectal cancer pathology and clinical guidelines. With the wider reporting of tumor budding, new issues have emerged that require further clarification. To better inform researchers and health-care professionals on these issues, an international group of experts in gastrointestinal pathology participated in a modified Delphi process to generate consensus and highlight areas requiring further research. This effort serves to re-affirm the importance of tumor budding in colorectal cancer and support its continued use in routine clinical practice.
|
|
| 9. |
- Karlsson, Per Erik, et al.
(författare)
-
The vulnerability of northern European vegetation to ozone damage in a changing climate An assessment based on current knowledge
- 2021
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The potential vulnerability of vegetation at northern latitudes to ozone damage was assessed based on current knowledge with regard to air ozone concentrations and leaf ozone uptake as well as to plant traits affecting ozone tolerance. The focus was on the northern European arctic, alpine and northern boreal vegetation zones, with a special focus on high-altitude vegetation. In particular, we analysed if there are increasing risks for ozone impacts on northern vegetation due to high spring ozone concentrations in relation to climate change induced shifts such as e.g. an earlier start of the growing season. The ozone concentrations in these regions are characterized by the influence of a combination of conditions caused by high latitudes and high altitudes. Ozone concentrations increase with altitude and the difference in ozone concentrations between day and night are smaller at high-altitude and high-latitude sites. Summer periods with long daylight conditions potentially promote the leaf ozone uptake through the open stomata. The aims of this report were: • To assess the current state of knowledge regarding the potential vulnerability of far northern vegetation to ozone damage, today and in the future • To provide advice for policy implications regarding necessary ozone precursor emission abatement • To provide advice for future research and monitoring of ozone impacts on the vegetation at northern latitudes Ongoing environmental changes affecting far northern latitude ecosystems were reviewed. Current and novel methods were described for how to estimate the time of year during which the ozone exposure for vegetation should be accumulated. Time trends for ozone concentrations at northern latitudes were analysed. Ozone episodes with high concentrations at far northern latitudes were described. Source attributions of northern ozone concentrations were analysed. Environmental conditions at far northern latitudes that might be important for ozone damage were evaluated. Plant traits that can influence the ozone vulnerability were discussed. Current experimental results for ozone injury on northern plant species were evaluated. Future scenarios for ozone impact on northern vegetation were discussed. Some important results from the analyses are described below. At high altitudes and high latitudes, the ozone concentrations are relatively similar during day- and night-time. Furthermore, at high latitudes, the long daylight duration during the summer has the potential to increase the duration of the daily period with plant gas exchange and leaf ozone uptake. Therefore, the absorption of ozone through the stomata may potentially be higher at northern latitudes. However, measurements of light intensity and quality at northern sites in combination with a simple calculation example illustrated that this probably was not the case, since the potential added ozone uptake in the early morning and late evening at northern sites may be cancelled out by a lower ozone uptake in the middle of the day, as compared to southern sites. Both data on budburst and data on ecosystem CO2 exchange as well as meteorological observations show that there has been a development towards an earlier start of the growing season during the year, with approximately 0.5 – 1 day per year. Thus, there is clear evidence for an earlier start of the growing season, which is likely to continue. However, the timing of the spring ozone maximum is also shifted towards earlier in the year. There is presently no evidence for an increasing overlap between the growing season and the ozone peak. Despite this, there is a potential for increased ozone uptake to vegetation in spring due to the earlier growing start of vegetation and increased uptake of ozone to vegetation in May. The impact of this on the accumulated phytotoxic ozone dose for northern vegetation needs to be investigated further. The overall conclusions about the present and near future ozone vulnerability of northern vegetation were: • There remain uncertainties regarding to what extent northern vegetation is affected by ozone exposure. • According to current knowledge, we could not find evidence that expected changes in ozone concentrations and climate would make the northern arctic, alpine and subalpine vegetation substantially more vulnerable to ozone than other types of European vegetation. • The risk of significant and lasting negative impact of the current exposure to ozone on northern boreal forests is most likely not greater than for boreonemoral and nemoral forests in southern Fennoscandia. • However, peak ozone concentrations occurring in spring and early summer may affect vegetation at northern latitudes in Fennoscandia since the start of the growing season in the future may occur earlier during the year. The policy implications that can be derived from these conclusions were: • The current state of knowledge implies that ecosystems in the far north are not more susceptible to ozone than vegetation in other parts of Europe. Hence, we cannot advocate for a stronger reduction of ozone precursors emissions based exclusively on the ozone sensitivity of vegetation in the far north. • Policies designed to reduce emissions of ozone precursors to protect vegetation in other parts of Europe as well as in the entire northern hemisphere are likely to suffice to protect vegetation in northern Fennoscandia. There are important remaining knowledge gaps. Our conclusions are based on important, but limited observations. Experimental evidence from investigations specifically designed to study ozone sensitivity of high-altitude vegetation in northern Europe are to a large extent lacking. It is recommended that further experimental research is undertaken to directly compare the ozone sensitivity of plants of high-latitude/high-altitude origin with that of plants (species, genotypes) representative of regions of the southern part of the Nordic region. This research should include the characteristics of the high-latitude climate and other conditions. A specific research question is if the new ozone critical levels for European vegetation based on PODYSPEC (Mapping Manual, 2017) are correct, both regarding calculation methodology as well as impact assessments? In particular, there is a lack of information about the degree of stomata closure during nights in high-latitude area plants. This is important for the modelling of ozone uptake (dry deposition) in these areas and requires coordinated measurement campaigns in close cooperation with modelers. Further research questions may be related to the future development of the northern regions – e.g. oil and gas extraction including flaring, shipping, more tourism and climate change – how will that affect the ozone exposure of in the northern vegetation? Do future ozone precursor emission scenarios describe this correctly? Will warm and dry summers like 2018 become more frequent in connection with climate change, and how will this affect ozone impacts on vegetation? There are currently very few, long term ozone monitoring stations in the arctic and alpine vegetation zones, in particular at high altitudes. Given the expected increase in anthropogenic activities in these areas in combination with climate change, it is strongly recommended to increase the number of high-altitude ozone monitoring sites in these regions.
|
|
| 10. |
- Langner, J., et al.
(författare)
-
Model-simulated source contributions to PM2.5 in Santiago and the central region of Chile
- 2020
-
Ingår i: Aerosol and Air Quality Research. - : Taiwan Association for Aerosol Research. - 2071-1409 .- 1680-8584. ; 20:5, s. 1111-1126
-
Tidskriftsartikel (refereegranskat)abstract
- The contributions to PM2.5 from different emission sectors across central Chile and the Santiago metropolitan area during summer/fall and winter have been evaluated using a chemical transport model. The simulations generally underestimate the mean PM2.5 concentrations compared to measurements conducted at stations in Santiago that belong to the Chilean National Air Quality Information System (SINCA). The potential reasons for this discrepancy include underestimated direct PM2.5 emissions, missing emissions for semi-and intermediately volatile organic compounds (SVOCs and IVOCs) and overestimated wind speeds in the simulations. The simulated winter PM2.5 concentrations in Santiago are lower and higher than the values observed during nighttime, and daytime and late evening, respectively, which may be related to excessive simulated wind speeds, as well as to uncertainties in the diurnal variation in the emissions. During summer/fall, the simulated diurnal variation better agrees with the observations, but the peak concentrations during the morning are underestimated, whereas those during the evening are overestimated. The simulated contributions of different aerosol components to the PM2.5 at one station in Santiago are all lower than the observed values, except for elemental carbon equivalent black carbon (BCe), which exhibit comparable or higher levels in the simulations. The absolute differences are the largest for the total organic matter, whereas the relative differences are the largest for BCe and ammonium. The simulated sector contributions indicate that emissions originating from transport and construction machinery dominate the PM2.5 in Santiago; however, residential wood combustion is the primary source in other urban areas of central Chile, except near major point sources. Away from urban areas, traffic routes and major industrial sources, secondary inorganic aerosol (SIA) is estimated to be the largest component of the aerosol, whereas the simulated secondary organic aerosol (SOA) only contributes a small fraction.
|
|
