| 1. |
- Tuskan, G A, et al.
(författare)
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The genome of black cottonwood, Populus trichocarpa (Torr. & Gray).
- 2006
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 313:5793, s. 1596-604
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Tidskriftsartikel (refereegranskat)abstract
- We report the draft genome of the black cottonwood tree, Populus trichocarpa. Integration of shotgun sequence assembly with genetic mapping enabled chromosome-scale reconstruction of the genome. More than 45,000 putative protein-coding genes were identified. Analysis of the assembled genome revealed a whole-genome duplication event; about 8000 pairs of duplicated genes from that event survived in the Populus genome. A second, older duplication event is indistinguishably coincident with the divergence of the Populus and Arabidopsis lineages. Nucleotide substitution, tandem gene duplication, and gross chromosomal rearrangement appear to proceed substantially more slowly in Populus than in Arabidopsis. Populus has more protein-coding genes than Arabidopsis, ranging on average from 1.4 to 1.6 putative Populus homologs for each Arabidopsis gene. However, the relative frequency of protein domains in the two genomes is similar. Overrepresented exceptions in Populus include genes associated with lignocellulosic wall biosynthesis, meristem development, disease resistance, and metabolite transport.
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| 2. |
- Larimer, M.E., et al.
(författare)
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An international comparison of a web-based personalized feedback intervention in high school students USA and Sweden
- 2013
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Ingår i: Alcoholism. - : John Wiley & Sons. - 0145-6008 .- 1530-0277. ; 37:s2, s. 260A-260A
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- A key developmental period for alcohol misuse is emerging adulthood (roughly ages 18–25). Personalized Feedback Interventions (PFI) are effective in reducing alcohol-related harmin college populations, however little research has evaluated PFIs given during high school.Moreover, cultural differences influence both alcohol misuse and response to interventions. The purpose of this study is to evaluate the efficacy of a web-based PFI given to high school seniors (ages 17-19) in the USA and Sweden. 1181 participants (42.3%male; 28.3%risky drinkers based on AUDIT-C) in the USA and 2171 in Sweden (44.1%male; 52.3% risky drinkers based on AUDIT-C) were assessed during their high school senior year. Approximately 1/3 were randomized to receive PFI. Approximately 1 week after viewing the PFI, participants were asked to complete a post-feedback satisfaction survey (3 subscales: information motivated change, shared information with friends, information was educational), and their “stage” on the readiness to change scale. Results showed 1) information motivated change subscale was associated with increases in contemplation and action stages of change and decreases in precontemplation; Swedish participants and those with higher AUDIT-C scores had lower scores; (2) USA sample was less likely to share information with friends; those with higher AUDIT-C scores were more likely to share information with friends; and (3) those with higher AUDIT-C scores were less likely to find information educational. Participants completed 6- and 12- month follow up surveys. After controlling for key baseline variables and using appropriate distributions for analyses, 6 month outcomes from 2236 participants (852 in USA; 1384 in Sweden; 731 received PFI), found those who received PFI drank significantly less alcohol per occasion (typical and peak), had lower blood alcohol concentration (typical and peak) and drank on fewer occasions than those who did not receive the PFI (effect size range: d = .12 to d = .22). There were no significant effects of PFI on alcohol-related problems or readiness to change and no significant interactions between country of residence and intervention on drinking outcomes. Results suggest web-based PFIs given during senior year of high school are efficacious in reducing alcohol use during transition to adulthood. Twelve-month outcomes and mediators will also be presented. This research was supported by NIAAA # 5R01AA018276 awarded to Drs. Larimer & Berglund.
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| 3. |
- Andersson, Claes, et al.
(författare)
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Relationship of Protective Behavioral Strategies to Alcohol Consequences Among Swedish High School Seniors : Moderating Role of Conduct Disorder Symptoms
- 2012
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Ingår i: Alcoholism. - : Wiley-Blackwell. - 0145-6008 .- 1530-0277. ; 36:s1, s. 67A-67A
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- This observational study sought to improve our understanding of factors that contribute to risky sexual behavior among women seeking treatment for alcohol and other substance use disorders. Women were recruited at the start of outpatient (n=236) or inpatient (n=166) treatment. At intake, a Timeline Follow-back interview was used to obtain retrospective reports of daily drinking, drug use, and sexual behavior for a 90-day pre-treatment baseline period. Additional interview and questionnaire measures also were obtained. Measures were re- administered at four 90-day follow-up interviews. Among women who reported sex with a primary partner during baseline (n=261), 15% reported consistent condom use for all events with this partner, whereas 80% reported no condom use with this partner. Among women who reported sex with a non-primary partner (n=159; doesn’t include commercial sex trading), 26% reported consistent condom use and 45% reported no condom use with such partners. Significant correlates of non-use of condoms included negative beliefs and attitudes and low self-efficacy regarding condom use and AIDS prevention, as well as psychological distress, sexual impulsiveness and sensation seeking, history of severe assault by a male partner, and (with primary partners) negative partner attitudes toward condom use. Some of these correlates also predicted unprotected sex with a primary partner during the first 90 days after treatment entry, after controlling for baseline. However, unsafe sex with a non-primary partner during follow-up was most notably associated with follow-up levels of substance use, i.e., more drinks per drinking day and greater frequency of alcohol, marijuana, and cocaine use. In sum, preliminary analyses of baseline and follow-up data indicate a high prevalence of unprotected sex in this population. Identification of factors related to baseline and follow-up levels of risky behavior may suggest targets for future intervention development.
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| 4. |
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| 5. |
- Berglund, Mats, et al.
(författare)
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Self-reported disability in relation to alcohol and other drug use and mental health among emerging adults : an international comparison
- 2012
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Ingår i: Alcoholism. - : John Wiley & Sons. - 0145-6008 .- 1530-0277. ; 36:s1, s. 284A-284A
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The present study includes baseline data from 2867 students (77.8% from Sweden, 22.2% from US) and evaluates the relationships among self-reported disabilities, alcohol use, other substance use, and psychosocial adjustment. There were 114 (4.6%) ‘‘hard-of-hearing’’ (HH) students, 129 (5.2%) reported visual disabilities, 33 (1.3%) reported motor disabilities, 223 (9.0%) reported a reading/writing disability, and 97 (3.6%) reported they had ‘‘other’’ disabilities. Of these, 70 (14.1%) reported more than one disability. Presence of a disability was significantly higher among Sweden students (2 (1)=19.93, p< 0.001), with 19.1% of Sweden students and 11.5% of US students reporting at least one disability. Reporting any type of disability was associated with significantly greater alcohol use frequency, intensity, and related problems (all p < 0.02), significantly more mental health symptoms and conduct problems (p < 0.005), and significantly greater likelihood of illicit and prescription drug use (all p < 0.001). With respect to specific disabilities, individuals with motor disabilities reported the highest levels of alcohol use and mental health symptoms, whereas individuals who reported ‘‘other’’ disabilities had higher rates of illicit drug use and conduct problems. Further, there was a significantly positive correlation between the number of disabilities and intensity of alcohol use, mental health symptoms, conduct problems, illicit and prescription drug use, and alcohol related problems (all p < 0.001). The association between conduct problems and disability (any disability and number of disabilities) was moderated by country of origin, gender, and drinking for coping reasons on the Drinking Motives Questionnaire. Participants in Sweden, males, and those who drank for coping reasons were more likely to report a relationship between disability and conduct problems (p < 0.001). Participants who drank for coping reasons were also more likely to report a relationship between disability and alcohol related problems (p=0.001). These findings indicate students with disabilities are an important risk group for preventive interventions for alcohol, substance, and mental health problems, and may benefit from interventions which target healthy coping skills. This research was supported by NIAAA # 5R01AA018276 awarded to Drs. Larimer & Berglund
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| 6. |
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| 7. |
- Valenstein-Mah, Helen, et al.
(författare)
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Facets of mindfulness predict drinking consequences in a sample of American and Swedish adolescents
- 2015
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Ingår i: Alcoholism: Clinical and Experimental Research. - : John Wiley & Sons. ; 39:S1, s. 146A-146A
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Mindfulness-based interventions have become increasingly utilized with individuals with alcohol and substance use disorders (e.g., Bowen et al., 2014); however, the relationship between mindfulness and substance use is complex (Karyadi et al., 2014). Mindfulness is a multifaceted construct and includes factors related to attentional control, present moment focus, and an attitude of non-judgment and acceptance. Thus, the relationship between different mindfulness factors and substance use, and negative consequences related to its use, may differ. In the present study, we examined which specific elements of mindfulness would best predict drinking consequences 6 months later in a sample of American and Swedish adolescents. Additionally, we examined whether adolescents’ nationality would moderate the relationship between mindfulness and drinking consequences. Our sample included Washington St, USA and Swedish adolescents participating in a larger study investigating a brief online intervention for alcohol use (N = 3,352). Participants completed an online survey at 6- and 12-month follow up. At the 6-month follow up, trait-mindfulness wasmeasured using the Cognitive and AffectiveMindfulness Scale-Revised (Feldman et al., 2007). At 12-month follow up, alcohol related negative consequences were measured using the Rutgers Alcohol Problem Index (White & Lobouvie, 1989). Linear regression analysis revealed that mindfulness factors did explain a significant proportion of variance in drinking consequences scores, R2 = 0.02, F(4, 620) = 2.67, p = 0.03. Specifically, the mindfulness factor of attention predicted drinking consequences, such that lower levels of attention predictedmore drinking consequences, b = 0.23, p = 0.02. None of the other mindfulness factors significantly predicted drinking consequences. Adolescents’ nationality did notmoderate the relationship between the mindfulness factors and drinking consequences 6 month later. The present study findings differ from previous findings, which found a relationship between awareness and drinking consequences (Fernandez et al., 2010), although this may be due to differences in how mindfulness factors were conceptualized and assessed. Nationality was not shown to moderate the relationship between mindfulness factors and drinking consequences, suggesting that mindfulness factors may not be culturally bound and may operate consistently across cultures, although examination of additional cultures is needed.
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| 8. |
- Berglund, Mats, et al.
(författare)
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Perceived Risk for Cannabis, Tobacco and Alcohol : Comparison of US and Swedish High School Students
- 2014
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Ingår i: Alcoholism. - : John Wiley & Sons. - 0145-6008 .- 1530-0277. ; 38:s1, s. 347A-347A
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Aims: Perceived risk is related to use of cannabis, alcohol, and tobacco among youth. Sweden and US have different policies and customs related to these substances thatmay influence both risk perception and behavior regarding use of these substances. Differences in perceived risk of cannabis, cigarettes, chewing tobacco and alcohol in Sweden and the US have been reported but no direct systematic comparison has been performed. Design and setting: The ATLAS Project is a long-term longitudinal study comparing the development of substance use from high school to the young adult life period (18–23 years) in the US and Sweden. Participants: Baseline data for 3352 17–19 year-old high school students (65%from Sweden, 56% women, mean age 17.8, 35%from US 58%women,mean age 17.6). Measurements: Surveys of perceived risk items, ever use of cannabis, cigarettes and alcohol, as well as conduct problems, mental health symptoms, and impulsivity. Findings: The largest differences between the countries were found for the risk of cannabis use. Swedish participants reported much higher perceived risk both for continuous and occasional use than US students. For cigarettes, chewing tobacco and alcohol students from the US reported higher risk perception than the Swedish students did. Females reported higher perceived risk for all substances than male students.Conduct problems were associated with less perceived risk in all examples and impulsivity in cannabis and alcohol issues. Increasedmental health symptoms were associated with increased perceived risk for alcohol. Those who have used the specific drug reported lower levels of risk for that drug butmostly not for other drugs. Conclusions: Perceived risk for cannabis was higher in Swedish students than in US students while cigarette smoking, chewing tobacco and alcohol use were perceived as more risky in the US. One possibility could be that Sweden has much tougher drug laws than the US while less stringent alcohol and tobacco laws.
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| 9. |
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| 10. |
- Grazioli, V.S., et al.
(författare)
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Injunctive norms of alcohol-related consequences among high school students : impact on alcohol outcomes
- 2013
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Ingår i: Alcoholism. - : John Wiley & Sons. - 0145-6008 .- 1530-0277. ; 37:s2, s. 156A-156A
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Literature indicates that high school students experience numerous negative consequences related to drinking (Miller, Naimi, Brewer, & Jones, 2007). It is therefore important to understand determinants of drinking behaviors in this population, such as injunctive norms (i.e., perception of self and/or others’ approval of a specific behavior; Cialdini et al., 1990). A recent study among college students documented a discrepancy between personal attitudes about alcohol-related consequences and perceived attitudes of peers, with students perceiving peers to be more approving of alcohol-related consequences than themselves, which predicted higher rates of alcohol use (DeMartini, Carey, Lao, & Luciano, 2011). To our knowledge, this has not been studied among high school students. Thus, the purpose of the current study is to evaluate the predictive role of perceived differences in injunctive norms between self and peers for alcohol-related consequences among high school seniors. The sample included 3,352 students in the US (n = 1181, 57.7%female) and Sweden (n = 2171, 55.9% female), participating in an international longitudinal study about alcohol use trajectories. Measures included injunctive norms for self and friends for alcohol-related consequences (i.e., 7 items adapted from the RAPI; White & Labouvie, 1989), alcohol-related consequences (RAPI; White & Labouvie, 1989), and alcohol use (DDQ; Collins, Parks, & Marlatt, 1985). Paired samples t-tests were used to compare mean injunctive norms for self (M = 1.78), and friends (M = 2.02). There was a significant difference in perceived attitudes between self and friends (t (3173) = -17.76, p < .001) such that injunctive norms for self were lower than for friends. Next, regression analyses evaluated the discrepancy in injunctive norms for self and friends and its relation to alcohol outcomes. Differences between self and friends were computed by subtracting self from friends (F-S). F-S significantly predicted total drinks per week (b = .11, F (1, 3059) = 40.27, p < .001), average drinks per drinking occasion (b = .08, F (1, 3059) = 17.37, p < .001), and negative consequences (b = .21, F (1, 3113) = 143.09, p < .001). These results provide additional support of the importance of injunctive norms of alcohol-related consequences in young adults and have implications for prevention programs tailored to high school students. This research was supported by NIAAA #U01 AA018276 awarded to Drs. Larimer & Berglund.
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