| 1. |
- Nilsson, Christa, et al.
(författare)
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Characterization of Oil-Free and Oil-Loaded Liquid-Crystalline Particles Stabilized by Negatively Charged Stabilizer Citrem
- 2012
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Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 28:32, s. 11755-11766
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Tidskriftsartikel (refereegranskat)abstract
- The present study was designed to evaluate the effect of the negatively charged food-grade emulsifier citrem on the internal nanostructures of oil-free and oil-loaded aqueous dispersions of phytantriol (PHYT) and glyceryl monooleate (GMO). To our knowledge, this is the first report in the literature on the utilization of this charged stabilizing agent in the formation of aqueous dispersions consisting of well-ordered interiors (either inverted-type hexagonal (H2) phases or inverted-type microemulsion systems). Synchrotron small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM) were used to characterize the dispersed and the corresponding nondispersed phases of inverted-type nonlamellar liquid-crystalline phases and microemulsions. The results suggest a transition between different internal nanostructures of the aqueous dispersions after the addition of the stabilizer. In addition to the main function of citrem as a stabilizer that adheres to the surface of the dispersed particles, it has a significant impact on the internal nanostructures, which is governed by the following factors: (1) its penetration between the hydrophobic tails of the lipid molecules and (2) its degree of incorporation into the lipid–water interfacial area. In the presence of citrem, the formation of aqueous dispersions with functionalized hydrophilic domains by the enlargement of the hydrophilic nanochannels of the internal H2 phase in hexosomes and the hydrophilic core of the L2 phase in emulsified microemulsions (EMEs) could be particularly attractive for solubilizing and controlling the release of positively charged drugs.
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| 2. |
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| 3. |
- Arlien-Soborg, Mai C., et al.
(författare)
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Acromegaly management in the Nordic countries: A Delphi consensus survey
- 2024
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Ingår i: Clinical Endocrinology. - : WILEY. - 0300-0664 .- 1365-2265.
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Tidskriftsartikel (refereegranskat)abstract
- ObjectiveAcromegaly is associated with increased morbidity and mortality if left untreated. The therapeutic options include surgery, medical treatment, and radiotherapy. Several guidelines and recommendations on treatment algorithms and follow-up exist. However, not all recommendations are strictly evidence-based. To evaluate consensus on the treatment and follow-up of patients with acromegaly in the Nordic countries.MethodsA Delphi process was used to map the landscape of acromegaly management in Denmark, Sweden, Norway, Finland, and Iceland. An expert panel developed 37 statements on the treatment and follow-up of patients with acromegaly. Dedicated endocrinologists (n = 47) from the Nordic countries were invited to rate their extent of agreement with the statements, using a Likert-type scale (1-7). Consensus was defined as >= 80% of panelists rating their agreement as >= 5 or <= 3 on the Likert-type scale.ResultsConsensus was reached in 41% (15/37) of the statements. Panelists agreed that pituitary surgery remains first line treatment. There was general agreement to recommend first-generation somatostatin analog (SSA) treatment after failed surgery and to consider repeat surgery. In addition, there was agreement to recommend combination therapy with first-generation SSA and pegvisomant as second- or third-line treatment. In more than 50% of the statements, consensus was not achieved. Considerable disagreement existed regarding pegvisomant monotherapy, and treatment with pasireotide and dopamine agonists.ConclusionThis consensus exploration study on the management of patients with acromegaly in the Nordic countries revealed a relatively large degree of disagreement among experts, which mirrors the complexity of the disease and the shortage of evidence-based data.
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| 4. |
- Arlien-Søborg, Mai C., et al.
(författare)
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Acromegaly management in the nordic countries : a Delphi consensus survey
- 2024
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Ingår i: Clinical Endocrinology. - : John Wiley & Sons. - 0300-0664 .- 1365-2265.
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Acromegaly is associated with increased morbidity and mortality if left untreated. The therapeutic options include surgery, medical treatment, and radiotherapy. Several guidelines and recommendations on treatment algorithms and follow-up exist. However, not all recommendations are strictly evidence-based. To evaluate consensus on the treatment and follow-up of patients with acromegaly in the Nordic countries.Methods: A Delphi process was used to map the landscape of acromegaly management in Denmark, Sweden, Norway, Finland, and Iceland. An expert panel developed 37 statements on the treatment and follow-up of patients with acromegaly. Dedicated endocrinologists (n = 47) from the Nordic countries were invited to rate their extent of agreement with the statements, using a Likert-type scale (1−7). Consensus was defined as ≥80% of panelists rating their agreement as ≥5 or ≤3 on the Likert-type scale.Results: Consensus was reached in 41% (15/37) of the statements. Panelists agreed that pituitary surgery remains first line treatment. There was general agreement to recommend first-generation somatostatin analog (SSA) treatment after failed surgery and to consider repeat surgery. In addition, there was agreement to recommend combination therapy with first-generation SSA and pegvisomant as second- or third-line treatment. In more than 50% of the statements, consensus was not achieved. Considerable disagreement existed regarding pegvisomant monotherapy, and treatment with pasireotide and dopamine agonists.Conclusion: This consensus exploration study on the management of patients with acromegaly in the Nordic countries revealed a relatively large degree of disagreement among experts, which mirrors the complexity of the disease and the shortage of evidence-based data.
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| 5. |
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| 6. |
- Benner, Mats, et al.
(författare)
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Are some technical universities better than others?
- 2020
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Ingår i: Technical Universities : Past, Present and Future - Past, Present and Future. - Cham : Springer International Publishing. - 9783030505547 - 9783030505554 ; , s. 27-43
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Bokkapitel (refereegranskat)abstract
- Technical universities is an omnibus concept, which may conceal variations. This is the fundamental assumption of this chapter, which deals with three technical universities in three European countries: KTH in Sweden, DTU in Denmark, and EPFL in Switzerland. Based on an analysis of scientific impact profiles and their alignment with government steering, funding and internal organisation and leadership, it is concluded that there are marked variations between the three technical universities. It cannot be said that one technical university is better than others; only that they configure tasks and roles differently.
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| 8. |
- Berg Mårtensson, Hampus, et al.
(författare)
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Investigating potential effects of mobility and accessibility services using the avoid-shift-improve framework
- 2023
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Ingår i: Sustainable cities and society. - : Elsevier BV. - 2210-6707. ; 96, s. 104676-104676
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Tidskriftsartikel (refereegranskat)abstract
- Mobility services and accessibility services could contribute to reduced car-dependency and a more sustainable transport system. However, uncertainty remains regarding what the effects will be and further research is needed. In this paper we examine potential effects on passenger car-travel in an urban context. To do so, we actuate the Avoid-Shift-Improve (ASI) framework using a System Dynamics approach and develop thematic Causal Loop Diagrams. We draw on the findings from a literature study and workshops engaging actors involved in creating visions and planning for the future of mobility and accessibility services in Stockholm, Sweden. The effects discovered are categorized as direct, enabling and structural/systemic, using a retrofitted version of the Three-Levels Model. Contributions include the mapping of mechanisms through which the services can have positive and negative effects in relation to ASI, demonstrating a high degree of interconnectedness. This includes potential synergetic and competitive relations between the services. In addition, the approach gives insight to potential cumulative impact of the services, relatable to Mobility as a Service, including ‘user near’ effects regarding, e.g., commuting and leisure travel, as well as systemic and structural level effects. A discussion is conducted on the implications for actors and policy-makers.
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| 9. |
- Bienkowska, Dzamila, et al.
(författare)
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Public-private innovation : Mediating roles and ICT niches of industrial research institutes
- 2010
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Ingår i: INNOV-MANAG POLICY PRACT. - : Informa UK Limited. - 1447-9338. ; 12:2, s. 206-216
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Tidskriftsartikel (refereegranskat)abstract
- Innovation processes involve diverse sets of organizations including universities, private firms, corporate research labs and public research institutes. Collaborative forms of knowledge production and innovative activity enable actors to reduce risk, specialize, and take advantage of knowledge internal and external to the own organization. This paper discusses interactions and collaborations between public and private sector innovation. This is done through an analysis of semi-public research institutes in Sweden and their roles as arenas for R&D processes involving industry, university and government in terms of funding, research and public-private innovation. Particular attention is paid to technological niches of research institutes and utilization of research findings from collaborative R&D. The results show that institutes occupy specific niches which influence their ways of transferring knowledge. It is argued that diversity among R&D performers as well as funding opportunities is paramount for innovation systems to thrive.
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| 10. |
- Broström, Anders, Docent, 1978-, et al.
(författare)
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Concluding Discussion : The Past, Present, and Future of Technical Universities
- 2020. - 1
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Ingår i: Technical Universities. - Cham : Springer Nature. ; , s. 227-242
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Bokkapitel (refereegranskat)abstract
- Higher education institutions identified as ‘technical universities’ enjoy considerable status in many countries. Yet studies of boundary negotiations from a range of settings suggest that opportunities to transform into a broader, research-based university often takes precedence over the alternative vision of remaining or moving towards becoming a focused technical university. In this chapter, we discuss alternative explanations for the lacklustre appeal of the latter type of institutional template, and outline a roadmap for how the historical legacy of the technical university may be cultivated.
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