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Sökning: WFRF:(Larsen Mattias 1975)

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  • Justice, A. E., et al. (författare)
  • Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
  • 2017
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.
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  • Larsen, Mattias, 1975 (författare)
  • Globalization and governance of uncertainty
  • 2008
  • Ingår i: Paper presented at the 12th EADI Conference on Global Governance for Sustainable Development: The Need for Policy Coherence and New Partnerships, Geneva, Switzerland, 24-28 June 2008.
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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  • Larsen, Mattias, 1975, et al. (författare)
  • Intergenerational interests, uncertainty and discrimination: Conceptualising the process of declining child sex ratios in India
  • 2006
  • Ingår i: Paper for the International Conference on Emerging Population Issues in the Asia Pacific Region: Challenges for the 21st Century, International Institute for Population Sciences, 10-13 December 2006, Mumbai, India.
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • This article builds upon the recognition that the declining child sex ratios are a result of an ongoing process of societal change. Looking at areas which have shown significant declines in child sex ratios between 1991 and 2001, the article draws on results from recently conducted field studies in rural areas of Karnataka in the South and of Uttaranchal in the North. Uttaranchal has shown an alarming decline in the child sex ratio from 948 in 1991 to 906 in 2001. Of special interest are results of case studies from Siddapur Taluk7, Uttara Kannada District, in the Western Ghats of Karnataka and from Pithoragarh Tehsil, Pithoragarh District, in the eastern part of Uttaranchal8. For both cases the outstanding feature is a very low child sex ratio. Two additional cases with high child sex ratios are used for comparative purposes.
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