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- Asp, Michaela, et al.
(författare)
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A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart
- 2019
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Ingår i: Cell. - : CELL PRESS. - 0092-8674 .- 1097-4172. ; 179:7, s. 1647-
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Tidskriftsartikel (refereegranskat)abstract
- The process of cardiac morphogenesis in humans is incompletely understood. Its full characterization requires a deep exploration of the organ-wide orchestration of gene expression with a single-cell spatial resolution. Here, we present a molecular approach that reveals the comprehensive transcriptional landscape of cell types populating the embryonic heart at three developmental stages and that maps cell-type-specific gene expression to specific anatomical domains. Spatial transcriptomics identified unique gene profiles that correspond to distinct anatomical regions in each developmental stage. Human embryonic cardiac cell types identified by single-cell RNA sequencing confirmed and enriched the spatial annotation of embryonic cardiac gene expression. In situ sequencing was then used to refine these results and create a spatial subcellular map for the three developmental phases. Finally, we generated a publicly available web resource of the human developing heart to facilitate future studies on human cardiogenesis.
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| 4. |
- Chapman, David, 1972-, et al.
(författare)
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Climate change and human behaviour : Understanding modal choice in a rapidly urbanising Arctic
- 2019
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This poster explores the human dimension of non-motorised transport, i.e. soft-mobility in Arctic communities. Empirical results are used to show how people’s modal choice in the European Arctic is being influenced by climate evolution and human-made climate change. From these results, it is possible to conceive new visions of the how to design the outside environments of Arctic settlements that can better enable people to move around in Arctic communities with reduced reliance on vehicles. At the societal level, this research will help reduce energy consumption and pollution from transport.
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| 5. |
- Chapman, David, 1972-, et al.
(författare)
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Climate change and human behaviour : Understanding modal choice in a rapidly urbanising Arctic
- 2020
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Ingår i: Arctice Frontiers Science.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This research explores the human dimension of non-motorised transport, i.e. soft-mobility in Arctic communities. Empirical results are used to show how people’s modal choice in the European Arctic is being influenced by climate evolution and human-made climate change. From these results, it is possible to conceive new visions of the how to design the outside environments of Arctic settlements that can better enable people to move around in Arctic communities with reduced reliance on vehicles. At the societal level, this research will help reduce energy consumption and pollution from transport. For the individual, it highlights social, economic and the health benefits of soft-mobility. This includes creating places that are attractive, safe, and recognisable, as a basis for people’s informed decision-making about outdoor activities and modal choice. Pilot projects are ongoing in Riksgränsen, Björkliden and Abisko (Sweden) with data collected from residents and tourists using citizen science. Outcomes have practical and policy implications for town planning and tourism.
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| 6. |
- Chapman, David, 1972-, et al.
(författare)
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Designing winter cities : Arctic urbanisation and Asian mobilities consumption
- 2021
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Ingår i: Asian Mobilities Consumption in a Changing Arctic. - London : Taylor & Francis. ; , s. 168-180
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Bokkapitel (refereegranskat)abstract
- This chapter considers an urbanising Arctic and the design of winter cities with a specific focus on Asian mobilities consumption. The chapter explores how Asian consumption mobilities can be seen as the outcome of interactions between the built environment of Arctic settlements, individuals and climate.Special attention is placed on how the built environment of Arctic cities is modified and shaped by “winter”. The focus is placed on the theory of urban morphology, production of space and ongoing climate change. This is important in order to understand Asian tourist mobilities in Arctic settlements because these environments bring unexpected conditions and challenges for tourists’ perceptions of heritage sites and their mobility between them. The chapter concludes by presenting some urban design recommendations for Arctic cities that can assist in understanding and enabling Asian mobilities in a changing Arctic.
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| 7. |
- Chapman, David, 1972-, et al.
(författare)
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Practical urban planning for winter cycling : lessons from a Swedish pilot study
- 2021
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Ingår i: Journal of Transport & Health. - : Elsevier. - 2214-1405 .- 2214-1413. ; 21
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Tidskriftsartikel (refereegranskat)abstract
- IntroductionA detailed understanding of how the weather affects cycling is lacking. Where research has been carried out, the focus has often been on temperate and hotter climates; little research has been carried out regarding cycling in colder climate communities. This study therefore investigated the lived experience of winter-season cycling to provide empirical data for planning winter cycling in cold-climate communities.MethodsBetween 1 December 2017 and 30 April 2018, the activities of 13 cyclists (eight female and five male, mean age 42 years, age range 11–74 years) in Luleå, Sweden, were surveyed. Methods: Structured questionnaires, individual travel diaries, and recorded data for outdoor temperature, precipitation type, and snow cover were used.Results1) Cycle level and frequency could be maintained during the winter season; 2) in winter, participants were more likely to use their bicycles for commuting than other activities, 3) electric bicycles helped winter cycling significantly; 4) the quality of the cycling infrastructure is critical to making winter cycling attractive.ConclusionFor winter cycling to be successful, town planners need to consider winter cycling as a specific activity with its own design, policy and management requirements. This study has shown that year-round cycling can be achieved in cold-climate communities, with all its attendant potential health benefits.
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| 8. |
- Chapman, David, et al.
(författare)
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Social life and use of an Arctic city centre during the COVID-19 pandemic
- 2023
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Ingår i: Arctic Yearbook. - : University of the Arctic Thematic Network (TN) on Geopolitics and Security. - 2298-2418. ; , s. 185-200
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Tidskriftsartikel (refereegranskat)abstract
- From March 2020, regulations and recommendations were implemented in Sweden to reduce the spread of COVID-19, which included limitations to public life. Overall, these sought to reduce activities that brought people together and in so doing, transitioned the relationship between cities and people into a new paradigm.The study explores public usage of an Arctic city during the pandemic to understand how COVID-19 altered people’s ‘social life’. Data was collected in the Arctic city of Luleå, by structured questionnaires and semi-structured interviews. These indicate that: 1) a significant reduction in city visits, 2) multi-faceted city visits were reduced to single task based visits, 3) a significant reduction in leisure based activities, 4) an increase in digitalization of work, retail and leisure activities, 5) perceptions of responsibility, guilt, boredom and minimizing social networks were reported, and 6) post-pandemic, people questioned the ability of cities to bounce back.The survey and interviews show that in the Arctic city of Luleå, restrictions put in place to reduce spread of the infection had a significant impact on public life and use of the public realm, which is in accordance with research from outside the Arctic.The conclusion is that in the short term, the role of urban centres in daily life was reduced and the role of digitalisation for work, goods and services was rapidly advanced. However, the research also shows that the ‘social dimension’ of Arctic cities - to see other people and take part of civic life on site - was not easy to replace and is valued by the community.
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| 9. |
- Chapman, David, 1972-, et al.
(författare)
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Toward an Integrated Model for Soft-Mobility
- 2019
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Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 16:19
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Tidskriftsartikel (refereegranskat)abstract
- A key urban design challenge is to create built environments that encourage outdoor activityall year round. This study explores a new model for soft-mobility that places the interaction betweenthe urban form, the seasonal climate and climate change, and the individual at the center of people’ssoft-mobility choices, or in more general, their modal choice. The research methods used werecomparative studies of documents, surveys, mental mapping, and photo elicitation. These studieswere undertaken to research people’s outdoor activity in the built environment during the winterseason of a cold climate settlement. The results were analyzed against the three-dimensions of themodel. In the discussion it is argued that in places with significant climate variation, the interactionbetween the urban form, the season, and the individual together influence soft-mobility choices. Inturn, these interactions influence people’s level of outdoor activity and the individual health benefitssuch activity can aord. In conclusion, it is highlighted that all three dimensions of the model are in aconstant state of change and evolution, especially in relation to planning and development processesand climate change.
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| 10. |
- Emelyanova, Anastasia, et al.
(författare)
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Age-inclusive Arctic outdoor spaces: a policy review in four Nordic countries
- 2024
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Ingår i: International Journal of Circumpolar Health. - : Taylor & Francis. - 1239-9736 .- 2242-3982. ; 83:1
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Forskningsöversikt (refereegranskat)abstract
- In the last decade, policy strategies were adopted in response to population ageing in the Nordic countries. Governmental actions have to be evaluated in terms of their efficacy. The objective of this article is to identify and review the policies related to age-inclusive outdoor spaces in the Arctic regions of Nordic countries. Our analysis focuses on central government white papers that address the older adults in Finland, Norway, Sweden, and Iceland. A review of such policy documents provides insights into the predominant understandings of older adults and healthy ageing. Moreover, such analysis may identify “blind spots” in the national policies, especially regarding the sparsely researched northernmost and rural Arctic territories. Our results demonstrate how the older populations in the Nordic Arctic and their access to outdoor spaces are addressed in the policy documents. We found that with few exceptions, the older people of the rural Arctic is strikingly absent in the Nordic national governmental papers. Moreover, access to outdoor spaces is mentioned in general terms, and specific challenges of the rural Arctic context, such as the harsh climate, long winters and geographical distances are not addressed. The noticed omissions might be the result of “urban-rural”, “south-north”, “indoor-outdoor”, and “generalisation” biases.
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