| 1. |
- Hulsart Billström, Gry, 1982-
(författare)
-
Bone Regeneration with Cell-free Injectable Scaffolds
- 2017
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Bone is a remarkable multifunctional tissue with the ability to regenerate and remodel without generating any scar tissue. However, bone loss due to injury or diseases can be a great challenge and affect the patient significantly. Autologous bone grafting is commonly used throughout the world. Autograft both fills the void and is bone inductive, housing the particular cells that are needed for bone regeneration. However, a regenerative complement to autograft is of great interest as the use of biomaterials loaded with bioactive molecules can avoid donor site morbidity and the problem of a limited volume of material. Two such regenerative products that utilise bone morphogenetic protein (BMP)-7 and -2 have been used for more than a decade clinically. Unfortunately, several side effects have been reported, such as severe swelling due to inflammation and ectopic bone formation. Additionally, the products require open surgery and use of supra physiological doses of the BMPs due to poor localisation and retention of the growth factor. The purpose of this thesis was to harness the strong inductive capacity of the BMP-2 by optimising the carrier of this bioactive protein, thereby minimising the side effects that are associated with the clinical products and facilitating safe and localised bone regeneration. We focused on an injectable hyaluronan-based carrier developed through polymer chemistry at the University of Uppsala. The strategy was to use the body’s own regenerative pathway to stimulate and enhance bone healing in a manner similar to the natural bone-healing process. The hyaluronan-based carrier has a similar composition to the natural extracellular matrix and is degraded by resident enzymes. Earlier studies have shown improved properties when adding hydroxyapatite, a calcium phosphate that constitutes the inorganic part of the bone matrix. In Paper I, the aim was to improve the carrier by adding other forms of calcium phosphate. The results indicated that bone formation was enhanced when using nano-sized hydroxyapatite. In Paper II, we discovered the importance of crushing the material, thus enhancing permeability and enlarging the surface area. We wished to further develop the carrier system, but were lacking an animal model with relatively high throughput, facilitated access, paired data, and we were also committed to the 3Rs of refinement, reduction, and replacement. To meet these challenges, we developed and refined an animal model, and this is described in Paper III. In Paper IV, we sought to further optimise the biomaterial properties of the hydrogel through covalent bonding of bisphosphonates to the hyaluronan hydrogel. This resulted in exceptional retention of the growth factor BMP-2. In Paper V, SPECT/PET/µCT was combined as a tri-modal imaging method to allow visualisation of the biomaterial’s in situ action, in terms of drug retention, osteoblast activity and mineralisation. Finally, in Paper VI the correlation between existing in vitro results with in vivo outcomes was observed for an array of biomaterials. The study identified a surprisingly poor correlation between in vitro and in vivo assessment of biomaterials for osteogenesis.
|
|
| 2. |
|
|
| 3. |
- Frändén, Märit, 1973-
(författare)
-
"Att blotta vem jag är" : Släktnamnsskick och släktnamnsbyten hos samer i Sverige 1920–2009
- 2010
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this thesis is to describe surname patterns and changes of surname among the Sami of Sweden. It presents the results of three studies. The first is a survey of the present-day stock of surnames (family names) among the Sami community, based on the 2005 electoral register for the Swedish Sami Parliament. It investigates the proportions of names deriving from different languages, and the commonest names in each group. The same study was carried out for different areas, showing that the northernmost parts of Sweden have a Sami name stock significantly different from that of the majority population. Further south, the stock of names is less marked, but no area is without Sami elements.The second study, based on archival material, concerns changes of name by Swedish Sami to newly formed surnames, over the period 1920–2004. It examines not only the names adopted, but also the ones replaced; how the name stock has been affected by different patterns of name change; and, as far as possible, who the name changers were. The study shows that, for a long time, names derived from Sami and Finnish were replaced with names formed from Swedish. This may be largely because of the stigma once attached to Sami ethnicity. More recently, Sami-language names seem to have been retained to a greater extent, possibly owing to the improved status of the culture.The third study looks at name changes in favour of names marked as Sami in character. The data consist in part of archive materials, but above all of interviews with three Sami informants who have themselves adopted Sami-language surnames. This study presents the informants’ thoughts on ethnicity and changes of name.In addition to the author’s own studies, the thesis includes a review of earlier research on Sami surnames, hereditary and non-hereditary, and a list of individual surnames with literature references regarding their origins and meanings. In the thesis, name changes are studied as a single, overall process, with an emphasis on the role of names in society, in particular as ethnic markers.
|
|
| 4. |
- Linghede, Eva, 1978-
(författare)
-
Glitch i Idrottslandet : en kritiskkreativ undersökning av queeranden inom svensk idrott(svetenskap)
- 2019
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The dominant story in critical sports research is that sport is characterised by heteronormativity and hegemonic masculinity norms. These norms are manifested in sexism, homophobia, homonegativity and racism which affect all athletes, regardless of identity. Although important, this is a story that risks reinforcing ideas of how all sport “is”. The thesis is a response to calls from feminist theorists and sport researchers who argue that we need to move away from a logic of negativity built into critical theory and instead put our analytical tools to the task of constructing alternative possible scenarios. The aim of the thesis is to explore what some major strands within contemporary feminist theory can accomplish in relation to dominating stories about gender, sexuality and scientific knowledge production in sport research. More specifically, I explore how the concepts of figuration and intra-action can open up for other possible sport (science) worlds.The thesis consists of a frame-story and four articles, which in turn are based on three substudies. In the first substudy I interviewed boys and men who engage with horses and in horse riding. By engaging in a sport, equestrianism, that in Sweden is dominated by girls/women and female coded, they transgress and challenge – glitch – ideas of how Real sports boys/men should be, live and act. The interview stories from this study are enacted in various ways in article I and IV. In the second substudy I interviewed elite athletes with experiences of living non-straight and who in that way glitch heteronormativity in sports (sometimes also homonormativity). These stories make up the heart of the figurations presented in article II. In the third substudy, I explored athletic bodies that, due to intersex variations, glitch the idea that the only way of being a body (in sport) is to be male or female. This analysis is presented in article III.The thesis is populated by horseguys who challenge stereotypical masculinity norms, sporting contexts that turn heteronormativity up-side-down and inside-out, athletic bodies that implode binary gender and a researcher I glitching a scientific (writing) genre. The figurations presented in the thesis open up for queering elsewheres, where engaging in sport can serve as a condition of possibility for same-sex attractions/relations and non-normative ways of being a boy/man, and where creative writing – in the form of fiction, poetry and genre mixing – can be used as a method of inquiry.Through the concept of intra-action, the thesis also makes visible that “matter matters”. Firstly, I show how engaging materially with horses allow and encourage boys/men to be less constrained by dominant gender norms – in other words, that human-horse relations are entangled with, and affect, boys’ and men’s doing of gender. Secondly, I make visible how athletic bodies “strike back” in relation to ideas of binary gender, glitching a dominant medico-scientific story (in sport) telling us that the only way of being a body is to be male or female. Thirdly, I enact – in form and content – how the researcher is always already entangled in scientific knowledge production.
|
|
| 5. |
- Nyberg, Gunn
(författare)
-
Ways of knowing in ways of moving : A study of the meaning of capability to move
- 2014
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The overall aim of this thesis has been to investigate the meaning of the capability to move in order to identify and describe this capability from the perspective of the one who moves in relation to specific movements. It has been my ambition to develop ways to explicate, and thereby open up for discussion, what might form an educational goal in the context of movements and movement activities in the school subject of physical education and health (PEH).In this study I have used a practical epistemological perspective on capability to move, a perspective that challenges the traditional distinction between mental and physical skills as well as between theoretical and practical knowledge. Movement actions, or ways of moving, are seen as expressions of knowing.In order to explore an understanding of the knowing involved in specific ways of moving, observations of actors’ ways of moving and their own experiences of moving were brought together. Informants from three different arenas took part: from PEH in upper secondary school, from athletics and from free-skiing.The results of the analyses suggest it is possible to describe practitioners’ developed knowing as a number of specific ways of knowing that are in turn related to specific ways of moving. Examples of such specific ways of moving may be discerning and modifying one’s own rotational velocity and navigating one’s (bodily) awareness. Additionally, exploring learners’ pre-knowing of a movement ‘as something’ may be fruitful when planning the teaching and learning of capability to move. I have suggested that these specific ways of knowing might be regarded as educational goals in PEH.In conducting this study, I have also had the ambition to contribute to the ongoing discussion of what ‘ability’ in the PEH context might mean. In considering specific ways of knowing in moving, the implicit and taken-for-granted meaning of ‘standards of excellence’ and ‘sports ability’can be discussed, and challenged.
|
|
| 6. |
- Sjöberg, Misa, 1966-
(författare)
-
Leadership and stress : indirect military leadership and leadership during complex rescue operations
- 2012
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The overall purpose of this thesis has been to increase the knowledge concerning leadership and stress in complex military and rescue operations. One of the biggest differences these leaders have to deal with compared to leaders in other kinds of organizations is the question of life and death. Their way of leading and handling stress may have consequences for their own lives, their subordinates' lives, and often also other people's lives.This thesis is based on four empirical studies which include multiple research methods, e.g. both qualitative and quantitative approaches. Paper I and II focus on indirect leadership in a military context and the main result are that indirect leadership can be understood as consisting of two simultaneous influencing processes. The first one is action-oriented and consists of interaction with a link which filters and passes the messages down to lower organizational levels. The second process is image-oriented and consists of being a role model. In the favourable case, trust is built up between the higher management and the employees. However, in the unfavourable case, there is a lack of trust, resulting in redefinitions of the higher managers' messages.Paper III and IV focused on leadership in complex and/or stressful rescue operations. In paper III, rescue operation commanders from complex operations were interviewed, and in paper IV, quantitative questionnaires were answered by informants from the ambulance services, the police force and the rescue services. The main result are that leadership in complex, stressful rescue operations can be understood as consisting of three broad timerelated parts: everyday working conditions, during an operation, and the outcome of an operation. The most important factors in explaining the outcome of a complex rescue operation were shown to be the organizational climate before an incident, positive stress reactions, and personal knowledge about one's co-actors during an operation.
|
|
| 7. |
- Tidlund, Mats
(författare)
-
Geotechnical risk management using the observational method
- 2021
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- There have been many cost overruns, time delays and quality problems reported from geotechnical engineering projects around the world during recent decades. Many of the reported problems are associated with risks related to the geotechnical conditions. To achieve a safe and cost-effective project with the desired quality, it is vital to adequately manage the geotechnical risks.The management of geotechnical risks includes a prediction of the geotechnical behavior. When it is difficult to predict the geotechnical behavior, the European design code, Eurocode 7, suggests the application of the observational method to verify the design. The main principle of this method is the use of observations and predefined measures to modify the design to comply with actual geotechnical conditions. Earlier research suggests that the observational method has the potential to manage geotechnical risks successfully, but the lack of guidelines related to its implementation has restricted the use of the method.The aim of this thesis is to enable a successful management of geotechnical risks in geotechnical engineering projects to improve quality and decrease costs related to geotechnical uncertainties.The research methodology used in the thesis was a multiple case study that included three geotechnical engineering projects. The case study was conducted in two steps, first an analysis of written information regarding the geotechnical risk management process in the projects, and then semi-structured interviews with key individuals involved in the geotechnical risk management process.The main research contribution is an increased knowledge of the key aspects for successful management of geotechnical risks, and the application of the observational method. Among other things, the thesis also discusses (1) the influence of the contractual framework on the management of geotechnical risks and application of the observational method, (2) management aspects of the observational method, and (3) the recommended roles of the actors involved in the risk management process.
|
|
| 8. |
- Wilson, Karin, 1955-
(författare)
-
Markusevangeliet i Lars Rangius samiska översättning från 1713
- 2008
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Lars Rangius translated the New Testament into Ume Saami in 1701–1713. The manuscript, comprising over 1000 pages, was never printed and is kept in The University Library in Uppsala. This study includes a transliteration of the Gospel of St. Mark and a description of the language. The language is studied from a phonological, morphological, syntactic and lexical point of view. An overview of the historical circumstances under which the translation was done is given and an investigation into the life of the translator, Lars Rangius, is also made in order to understand why he made this extensive work.
|
|
| 9. |
- Andersson, Joacim, 1978-
(författare)
-
Kroppsliggörande, erfarenhet och pedagogiska processer : en undersökning av lärande av kroppstekniker
- 2014
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The overall aim of this thesis is to theoretically explore and empirically analyse practical embodied knowledge in educational settings. In accordance to this aim an approach of body pedagogics is used in combination with classical pragmatism, using foremost William James’ and John Dewey’s concepts of experience, meaning, inquiry and habit. In addition, these concepts are combined with an idea of reflexive body techniques.A main focus lies on investigating the learning of body techniques in dinghy sailing by studying the process and the product of teaching and learning, the role of the instructor for sailors’ learning and the interplay between teaching and learning. The thesis entails three case studies consisting of video recordings of dinghy sailing, all using a combination of theoretical explorations and practical epistemology analysis (PEA). Empirical focus lies on how sailors grow into purposeful body techniques by taking the measure of their ongoing, continuous experience while coordinating their movements with the environment. The analyses show how understandings and bodily skills are simultaneously used in the educational situations where the dinghy sailors have to handle both the environment and various instructions given by the trainer. The result is presented through a descriptive model, comprising theoretical explorations and empirical analysis, through which it is possible to emphasise both the process and the content of the learning of body techniques. The methodological contribution of the thesis thus also consists of developed tools for analysing processes of body pedagogics at a micro level.
|
|
| 10. |
- Backman, Erik, 1972-
(författare)
-
Friluftsliv in Swedish Physical Education – a Struggle of Values : Educational and Sociological Perspectives
- 2010
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this thesis is to examine some of the educational and sociological conditions underlying the production of teaching in friluftsliv within the Physical Education (PE) subject in Swedish compulsory school. Despite the value awarded to the Scandinavian outdoor practice friluftsliv, in both the national PE curriculum document and in Physical Education Teacher Education (PETE) in Sweden, it does not seem to be thoroughly implemented in compulsory school teaching. Through analyses of interviews with PE teachers and PE teacher educators, as well as of curriculum documents, using the perspectives of Basil Bernstein and Pierre Bourdieu, I explore conditions underlying the expressions of friluftsliv teaching in Swedish PE. The pedagogic discourse for friluftsliv in Swedish PE is described as a teaching that should take place in a natural setting remote from civilisation, involve risks, and require time, technical equipment, financial resources, and cooperation. This discourse for friluftsliv is shown to be similar to the values emphasised in friluftsliv education in PETE. Although proven to be difficult to implement in school, this discourse appear to form the conception of friluftsliv teaching for PE teachers in Sweden. Under the influence of the performance code, friluftsliv is transformed into outdoor activities with which the PE teachers are familiar, or is totally left out of PE teaching. A turn towards options that are seen as unthinkable in relation to the current pedagogic discourse may benefit the achievement of the aims set out in the national PE curriculum. Values such as environmental awareness, sustainable development and cultural perspectives on the landscape could strengthen the classification of friluftsliv and PE in compulsory school. Further, an increase of socially critical and constructivist perspectives during PETE could make unthinkable options in friluftsliv thinkable and contribute to a break with the reproduction of teaching practices in PE.
|
|
