| 1. |
- Uhlén, Mathias, et al.
(författare)
-
A human protein atlas for normal and cancer tissues based on antibody proteomics
- 2005
-
Ingår i: Molecular & Cellular Proteomics. - 1535-9476 .- 1535-9484. ; 4:12, s. 1920-1932
-
Tidskriftsartikel (refereegranskat)abstract
- Antibody-based proteomics provides a powerful approach for the functional study of the human proteome involving the systematic generation of protein-specific affinity reagents. We used this strategy to construct a comprehensive, antibody-based protein atlas for expression and localization profiles in 48 normal human tissues and 20 different cancers. Here we report a new publicly available database containing, in the first version, similar to 400,000 high resolution images corresponding to more than 700 antibodies toward human proteins. Each image has been annotated by a certified pathologist to provide a knowledge base for functional studies and to allow queries about protein profiles in normal and disease tissues. Our results suggest it should be possible to extend this analysis to the majority of all human proteins thus providing a valuable tool for medical and biological research.
|
|
| 2. |
|
|
| 3. |
- Ahlstrand, Inger, et al.
(författare)
-
Health-promoting factors among students in higher education within health care and social work : a cross-sectional analysis of baseline data in a multicentre longitudinal study
- 2022
-
Ingår i: BMC Public Health. - London : BioMed Central. - 1471-2458. ; 22:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Educational environments are considered important in strengthening students’ health status and knowledge, which are associated with good educational outcomes. It has been suggested to establish healthy universities based on a salutogenic approach – namely, health promotion. The aim of this study was to describe health-promoting resources and factors among first-semester students in higher education in healthcare and social work.Methods: This cross-sectional study is based on a survey distributed among all students in seven healthcare and social work programmes at six universities in southern Sweden. The survey was carried out in 2018 using a self-reported, web-based questionnaire focussing on general health and well-being, lifestyle factors together with three validated instruments measuring health-promoting factors and processes: the Sense of Coherence (SOC) scale, Salutogenic Health Indicator Scale (SHIS) and Occupational Balance Questionnaire (OBQ).Results: Of 2283 students, 851 (37.3%) completed the survey, of whom 742 (87.1%) were women; 722 (84.8%) were enrolled on healthcare programmes, and 129 (15.2%) were enrolled on social work programmes. Most reported good general health and well-being (88.1% and 83.7%, respectively). The total mean scores for the SOC scale, SHIS and OBQ were, respectively, 59.09 (SD = 11.78), 44.04 (SD = 9.38) and 26.40 (SD = 7.07). Well-being and several healthy lifestyles were related to better general health and higher SOC, SHIS and OBQ scores. Multiple linear and logistic regressions showed that perceived well-being and no sleeping problems significantly predicted higher general health and higher SOC, SHIS and OBQ scores. Being less sedentary and non-smoking habits were significant predictors of higher SOC.Conclusions: Swedish students in higher education within the healthcare and social work sector report good general health and well-being in the first semester, as well as health-promoting resources (i.e. SOC, SHIS and OBQ), and in some aspects, a healthy lifestyle. High-intensity exercise, no sleeping problems and non-smoking seem to be of importance to both general health and health-promotive resources. This study contributes to knowledge about the health promotive characteristics of students in the healthcare and social work fields, which is of importance for planning universities with a salutogenic approach.
|
|
| 4. |
- Benaim, Andre, et al.
(författare)
-
Becoming An Innovative Company : Assessing An Organization’s Innovation Capability From The Perspective Of A Team
- 2014
-
Konferensbidrag (refereegranskat)abstract
- Literature points out the need for companies to innovate continuously. Such need requires that companies develop capacities to exploit and improve current work as well as to develop and explore more radical opportunities. This paper is a case study that investigates the innovation capabilities of a multinational manufacturing company by interviewing a group that is mandate to support the development of those capabilities. The data was collected by semi-structured interviews, which were based on the categories of a framework previously developed. The findings speak about the importance of setting clear processes for continuation and implementation of ideas, adequate allocation of resources and management support. The discussion and conclusion are about the importance of the integration of efforts in different organizational levels and some of the future challenges integrating the innovation efforts into a natural way of working.
|
|
| 5. |
- Benaim, Andre, et al.
(författare)
-
Building a pathway for innovation : Lessons learned from developing an online platform
- 2014
-
Ingår i: Proceedings of NordDesign 2014 Conference, NordDesign 2014. - Eespo, Finland : Aalto University. - 9781904670582 ; , s. 662-669
-
Konferensbidrag (refereegranskat)abstract
- Companies are constantly being pressured to innovate in order to stay competitive in the short run and have new offerings in the long run. One way of boosting innovation is to develop idea support systems that go beyond the traditional methods and tools. Through a qualitative study, this paper explores the lessons learned from developing an online platform for idea generation, and discusses it in terms of innovation process, climate, and capabilities. The results show that the platform itself is not enough for innovation. The structure and work processes around the platform are as important, which implies the need to design processes and procedures that allow an idea to develop, providing, focus, idea feedback and role clarity.
|
|
| 6. |
- Benaim, Andre, et al.
(författare)
-
The implementation of Innovation Metrics: A case study
- 2015
-
Ingår i: Proceedings of the 20th International Conference on Engineering Design. - : The Design Society. - 2220-4334 .- 2220-4342. - 9781904670711 ; 8, s. 213-224
-
Konferensbidrag (refereegranskat)abstract
- The paper explores the implementation process of an innovation measuring system prototype to support a heavy machinery multinational company to secure their innovative capability. In general, companies recognize the importance of becoming innovative to become, or remain, competitive on a global market. The case company decided to pilot a metric system that corresponds to the crucial factors to secure innovative capability and work with the stepwise improvement based on the assessment results. The methods are based on design-research approach and participatory action research. Interviews, surveys and observation were used, as well as, workshops were conducted to develop and follow up the implementation innovation measuring system. The findings explore topics and open questions related to metric selection, purpose and use of the selected indicators, as well as challenges related to the implementation of the metric system. Some of the conclusions question the viability of measuring project teams, as well as, it suggests the need for further research to clarify whether team metrics need to be develop in parallel to organizational ones.
|
|
| 7. |
- Bertoni, Alessandro, 1985-, et al.
(författare)
-
Mining data to design value : a demonstrator in early design
- 2017
-
Ingår i: DS87-7 PROCEEDINGS OF THE 21ST INTERNATIONAL CONFERENCE ON ENGINEERING DESIGN (ICED 17), VOL 7: DESIGN THEORY AND RESEARCH METHODOLOGY. - : The Design Society. - 9781904670957 ; , s. 21-29
-
Konferensbidrag (refereegranskat)abstract
- The paper presents a study run to verify the applicability of data mining algorithms asdecision support in early design stages of a product development project. The paperdescribes a two-stage scenario providing the rationale for the application of data science inengineering design. Furthermore, it describes a demonstrator showing how data can be fedback to the early design stages and can be used to populate models to reduce uncertainty indecision making. A wheel loader for constructions works is the reference product for thedemonstration. Data mining is applied on a dataset built on machine performances andcontextual and environmental data. The demonstrator focuses on the estimation of the fuelconsumption of alternative design concepts and estimates the performance variations givendifferent contextual variable. Finally, a way of visualizing the results of the data analysis inrelation to the tested and expected performances is presented.
|
|
| 8. |
- Bourdieu, Pierre, et al.
(författare)
-
Leve idrottspedagogiken : En vänbok tillägnad Lars-Magnus Engström
- 2005
-
Bok (övrigt vetenskapligt/konstnärligt)abstract
- Vem ägnar sig åt idrott? Vilken betydelse har fritiden i barns och ungdomars liv? Vad innebär hälsa i skolämnet idrott och hälsa?Leve idrottspedagogiken! tillägnas Lars-Magnus Engström. Texterna i boken speglar delar av det idrottspedagogiska forskningsområdet i Sverige, vars framväxt Lars-Magnus Engström varit den främste företrädaren för. Läsaren får här ta del av exempelvis idrottskulturen, fritidskulturen och skolans ämne idrott och hälsa. Genomgående handlar texterna om villkoren för barns och ungdomars deltagane och om de olika lärprocesser som sker i anslutning till idrottsutövning.Lars-Magnus Engström har gjort betydande insatser som forskare och lärare samt som professor vid Lärarhögskolan i Stockholm och vid Gymnastik- och idrottshögskolan. I snart fyrtion år har han arbetat med studier kring påverkans- och lärprocesser i idrott. Hans forskning har främst kretsat kring människors idrottsvanor och vilka som utvecklar en fysiskt aktiv livsstil. Idrotts- och motionsutövningar ger både ett så kallat egenvärde och investeringsvärde. Med dessa begrepp bland många andra har Lars-Magnus Engström bidragit till en fördjupad vetenskaplig förståelse av idrottskulturen.De flesta författarna har eller har haft Lars-Magnus Engström som handledare och tillhör forskningsgruppen för pedagogik, idrott och fritidskultur. Redaktörer för boken är Karin Redelius och Håkan Larsson.
|
|
| 9. |
- Dahlberg, Jenny, et al.
(författare)
-
Ten years transmission of the new variant of Chlamydia trachomatis in Sweden : prevalence of infections and associated complications
- 2018
-
Ingår i: Sexually Transmitted Infections. - : BMJ Publishing Group Ltd. - 1368-4973 .- 1472-3263. ; 94:2, s. 100-104
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: In 2006, a new variant of Chlamydia trachomatis (nvCT) was discovered in Sweden. It has a deletion in the plasmid resulting in failed detection by the single target systems from Abbott and Roche used at that time, whereas the third system used, from Becton Dickinson (BD), detects nvCT. The proportion of nvCT was initially up to 65% in counties using Abbott/Roche systems. This study analysed the proportion of nvCT from 2007 to 2015 in four selected counties and its impact on chlamydia-associated complications.METHODS: C. trachomatis-positive specimens collected from 2007 to 2015 were analysed by a specific PCR to identify nvCT cases. Genotyping was performed by multilocus sequence typing (MLST) and ompA sequencing. Ectopic pregnancy and pelvic inflammatory disease records were extracted from the national registers.RESULTS: In total, 5101 C. trachomatis-positive samples were analysed. The nvCT proportion significantly decreased in the two counties using Roche systems, from 56% in 2007 to 6.5% in 2015 (p<0.001). In the two counties using BD systems, a decrease was also seen, from 19% in 2007 to 5.2% in 2015 (p<0.001). Fifteen nvCT cases from 2015 and 102 cases from 2006 to 2009 had identical MLST profiles. Counties using Roche/Abbott systems showed higher mean rates of ectopic pregnancy and pelvic inflammatory disease compared with counties using BD systems.CONCLUSIONS: The nvCT proportion has decreased in all counties and converged to a low prevalence irrespective of previous rates. Genotyping showed that nvCT is clonal and genetically stable. Failing detection only marginally affected complication rates.
|
|
| 10. |
- Elfsberg, Jenny, 1973-, et al.
(författare)
-
Guiding Global Innovation Teams on their Exploration Journey : Learning from Aspiring Engineering Students
- 2024
-
Ingår i: International Journal of Engineering Education. - : Tempus Publications. - 0949-149X. ; 40:3, s. 472-490
-
Tidskriftsartikel (refereegranskat)abstract
- This research investigates globally dispersed innovation teams involved in explorative projects within an engineering graduate course employing problem-based learning. Utilizing insights from a longitudinal study, the objective is to identify how to enhance both individual learning and team performance, thereby increasing the likelihood of a successful outcome. Initial observations revealed common patterns in learning experiences among the top-performing teams, prompting further investigation into how supporting cohorts might positively influence both team performance and students’ learning experiences throughout the course. In addition to advancing comprehension of innovation team performance, the study introduces two lightweight tools designed as shared visual representations of the team’s exploration journey. These tools can assist supporting cohorts in guiding teams effectively. This research augments the existing body of knowledge surrounding the achievement of breakthrough innovations. It provides understanding about how to facilitate team performance and individual learning within globally dispersed innovation teams undertaking explorative projects. The proposed lightweight tools offer practical solutions to enhance the supporting cohort’s ability to guide and impact team performance and individual learning experiences. This study holds implications for academia and industry, particularly organizations reliant on radical innovation for competitiveness and future-proving. Lastly, the study’s findings could inform the design and delivery of future problem-oriented, project-organized learning-based courses in engineering education.
|
|
