| 1. |
- Geijer, Mats, 1957, et al.
(författare)
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Health-related quality of life in early psoriatic arthritis compared with early rheumatoid arthritis and a general population
- 2021
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Ingår i: Seminars in Arthritis and Rheumatism. - : Elsevier BV. - 0049-0172 .- 1532-866X. ; 51:1, s. 246-252
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Both psoriatic arthritis (PsA) and rheumatoid arthritis (RA) have a significant impact on quality of life, but few reports have compared the two diseases. The current study assessed health-related quality of life (HRQoL) in PsA at diagnosis and after five years compared with early rheumatoid arthritis (RA) and a matched general population. Methods: Patients with early PsA and early RA included in two Swedish registries with HRQoL data measured by the Medical Outcomes Study Short Form 36 (SF-36) at baseline and at five years follow-up were included. Differences in SF-36 scores compared with the general population were calculated for each patient. Physical function, disease activity, the delay before diagnosis, pain, and general wellbeing were used as explanatory variables. Statistical tests included t-tests and univariate and multivariate linear regression. Results: PsA (n = 166) and RA (n = 133) patients of both sexes had significantly reduced HRQoL at disease onset. After five years, PsA patients still had impairments in several domains of SF-36, whereas RA patients had an almost normalized HRQoL. The time from symptom onset to diagnosis, disease activity, and disability independently contributed to the reduced improvement in PsA. Conclusion: Both early PsA and RA are characterized by severely reduced HRQoL. Despite more severe disease at inclusion, normalization of HRQoL is seen in patients with RA but not PsA. This may be due to delay in the diagnosis of PsA or more powerful interventions in RA. Earlier detection, lifestyle intervention, and more aggressive management strategies may be needed for PsA. (C) 2020 Elsevier Inc. All rights reserved.
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| 2. |
- Poline, Mathias, et al.
(författare)
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Mutual neutralisation of O+ with O− : investigation of the role of metastable ions in a combined experimental and theoretical study
- 2021
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Ingår i: Physical Chemistry, Chemical Physics - PCCP. - : Royal Society of Chemistry (RSC). - 1463-9076 .- 1463-9084. ; 23:43, s. 24607-24616
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Tidskriftsartikel (refereegranskat)abstract
- The mutual neutralisation of O+ with O− has been studied in a double ion-beam storage ring with combined merged-beams, imaging and timing techniques. Branching ratios were measured at the collision energies of 55, 75 and 170 (± 15) meV, and found to be in good agreement with previous single-pass merged-beams experimental results at 7 meV collision energy. Several previously unidentified spectral features were found to correspond to mutual neutralisation channels of the first metastable state of the cation (O+(2Do), τ ≈ 3.6 hours), while no contributions from the second metastable state (O+(2Po), τ ≈ 5 seconds) were observed. Theoretical calculations were performed using the multi-channel Landau–Zener model combined with the anion centered asymptotic method, and gave good agreement with several experimentally observed channels, but could not describe well observed contributions from the O+(2Do) metastable state as well as channels involving the O(3s 5So) state.
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| 3. |
- Adrian-Kalchhauser, I., et al.
(författare)
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The round goby genome provides insights into mechanisms that may facilitate biological invasions
- 2020
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Ingår i: BMC Biology. - : Springer Science and Business Media LLC. - 1741-7007. ; 18:1
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Tidskriftsartikel (refereegranskat)abstract
- Background The invasive benthic round goby (Neogobius melanostomus) is the most successful temperate invasive fish and has spread in aquatic ecosystems on both sides of the Atlantic. Invasive species constitute powerful in situ experimental systems to study fast adaptation and directional selection on short ecological timescales and present promising case studies to understand factors involved the impressive ability of some species to colonize novel environments. We seize the unique opportunity presented by the round goby invasion to study genomic substrates potentially involved in colonization success. Results We report a highly contiguous long-read-based genome and analyze gene families that we hypothesize to relate to the ability of these fish to deal with novel environments. The analyses provide novel insights from the large evolutionary scale to the small species-specific scale. We describe expansions in specific cytochrome P450 enzymes, a remarkably diverse innate immune system, an ancient duplication in red light vision accompanied by red skin fluorescence, evolutionary patterns of epigenetic regulators, and the presence of osmoregulatory genes that may have contributed to the round goby's capacity to invade cold and salty waters. A recurring theme across all analyzed gene families is gene expansions. Conclusions The expanded innate immune system of round goby may potentially contribute to its ability to colonize novel areas. Since other gene families also feature copy number expansions in the round goby, and since other Gobiidae also feature fascinating environmental adaptations and are excellent colonizers, further long-read genome approaches across the goby family may reveal whether gene copy number expansions are more generally related to the ability to conquer new habitats in Gobiidae or in fish.
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| 4. |
- Allum, F., et al.
(författare)
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A localized view on molecular dissociation via electron-ion partial covariance
- 2022
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Ingår i: Communications Chemistry. - : Springer Science and Business Media LLC. - 2399-3669. ; 5:1
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Tidskriftsartikel (refereegranskat)abstract
- Inner-shell photoelectron spectroscopy provides an element-specific probe of molecular structure, as core-electron binding energies are sensitive to the chemical environment. Short-wavelength femtosecond light sources, such as Free-Electron Lasers (FELs), even enable time-resolved site-specific investigations of molecular photochemistry. Here, we study the ultraviolet photodissociation of the prototypical chiral molecule 1-iodo-2-methylbutane, probed by extreme-ultraviolet (XUV) pulses from the Free-electron LASer in Hamburg (FLASH) through the ultrafast evolution of the iodine 4d binding energy. Methodologically, we employ electron-ion partial covariance imaging as a technique to isolate otherwise elusive features in a two-dimensional photoelectron spectrum arising from different photofragmentation pathways. The experimental and theoretical results for the time-resolved electron spectra of the 4d(3/2) and 4d(5/2) atomic and molecular levels that are disentangled by this method provide a key step towards studying structural and chemical changes from a specific spectator site. Coincidence experiments at free-electron lasers enable time resolved site-specific investigations of molecular photochemistry at high signal rates, but isolating individual dissociation processes still poses a considerable technical challenge. Here, the authors use electron-ion partial covariance imaging to isolate otherwise elusive chemical shifts in UV-induced photofragmentation pathways of the prototypical chiral molecule 1-iodo-2-methylbutane.
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| 5. |
- Fahlgren, Anna, 1972-, et al.
(författare)
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Design and Outcome of a CDIO Syllabus Survey for a Biomedicine Program
- 2019
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Ingår i: The 15th International CDIO Conference: Proceedings – Full Papers. - Aarhus : Aarhus University. - 9788775074594 ; , s. 191-200
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Konferensbidrag (refereegranskat)abstract
- The CDIO Syllabus survey has successfully been applied to the Bachelor’s and Master’s programs in Experimental and Medical Biosciences, within the Faculty of Medicine and Health Sciences at Linköping University, Sweden. The programs are and have been, subject to considerable redesign with strong influence from the CDIO framework. One of the main drivers for the redesign is a shift concerning the main job market after graduation, from an academic career to industry and healthcare. One of the steps in the development process has been to carry out a Syllabus survey based on an adapted version of the CDIO Syllabus. The survey was sent out to students and to various categories of professionals, and in total 87 responses were received. The adapted version of the Syllabus and the design, execution, and outcome of the survey is presented.
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| 6. |
- Furberg, Anna, 1990, et al.
(författare)
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Life Cycle Environmental Impacts of Synthetic Diamond Production
- 2019
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Synthetic diamond is a superhard material found in applications such as cutting and grinding of rocks, minerals, metals and plastics, but also in windows and lenses in analytical equipment. Since the 1950s, when the synthesis of diamond via the high-pressure high-temperature (HPHT) synthesis was introduced, the use of synthetic diamond has gained increasing importance within industry, for example in cutting processes. Today, synthetic diamond dominates the industrial diamond use over its natural counterpart and the production is mainly via HPHT synthesis. Chemical vapor deposition (CVD) synthesis is also applied but to a lesser extent due to various technological issues, including the tendency of CVD diamond coatings to wear and tear in tooling applications. Nevertheless, a lot of research exist in the area of synthetic diamond film production via CVD synthesis addressing technological issues and CVD diamond has been described as the potential facilitator of a new diamond age. In the strive for sustainable production, it is important to investigate the environmental impacts associated with various products and life cycle assessment (LCA) is commonly applied for this purpose. Until now, however, no study has conducted LCA of conventional synthetic diamond production via HPHT synthesis and so far, only laboratory-scale LCA results have been presented for one CVD synthesis alternative. The aim of this study is to conduct a cradle-to-gate LCA for synthetic diamond production both via the conventional HPHT synthesis and the potentially emerging CVD synthesis. For the latter route of synthesis, prospective (or ex ante) LCA was conducted and a predictive scenario was constructed focusing on microwave CVD. Future scenarios were constructed, e.g. by modelling the background energy system both using a fossil-based mix, representing the currently dominating Chinese production, and a renewable energy mix in an explorative scenario. A comprehensive uncertainty analysis was furthermore conducted for the included parameters. Environmental impacts were compared between the two routes of synthesis and hotspots in synthetic diamond production identified. The results from this research can be applied as a foundation for further LCA studies of synthetic diamond products.
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| 7. |
- Furberg, Anna, 1990, et al.
(författare)
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What are the Life Cycle Environmental Impacts of Synthetic Diamond?
- 2019
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Synthetic diamond is due to its superior properties used in a wide range of applications including cutting and grinding of metals and rocks, but also in analytical equipment lenses and jewelry. The conventional production of synthetic diamond is energy-intensive and typically conducted via high-pressure high-temperature (HPHT) synthesis, while microwave chemical vapor deposition (MW-CVD) is also used but to a lesser extent. The purpose of this study is to assess the environmental impacts of synthetic diamond production via HPHT and MW-CVD synthesis. The method of life cycle assessment (LCA) is applied, where the environmental impacts of a product is studied over its life cycle. In this study, the parts of the life cycle included are the raw material extraction and manufacturing of synthetic diamond. Various types of environmental impacts are assessed, including global warming and acidification. Furthermore, the largest contributors in synthetic diamond production to the environmental impacts, i.e. the hotspots, are identified and potential improvements are discussed. Scenarios were constructed in order to assess the importance of the type of electricity mix that is applied in the production. Preliminary results from the study indicate that the cemented carbide (WC-Co) parts required for the high-pressure apparatus constitute a hotspot in the HPHT synthesis, while the required electricity constitutes a hotspot in the MW-CVD synthesis.The results provided from this study on conventional synthetic diamond production can be applied by synthetic diamond manufacturers in order to identify the largest potentials for improvement in their production. The results can also be used in future full LCA studies, which then include the whole life cycle of synthetic diamond products.
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| 8. |
- Gevorgian, Spartak, 1948, et al.
(författare)
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Optical electromagnetic wave generator
- 2003
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Patent (övrigt vetenskapligt/konstnärligt)abstract
- Microwaves are generated by heterodyning the outputs of two or more optical lasers which have differing central frequencies to produce beat frequencies in the microwave range. One of the beat frequencies is used to modulate the output of at least one of the lasers so as to produce sidebands which differ from the central frequency by an integral number of the sideband frequency. Each laser is connected to one of the other lasers by a weak optical link to optically injection lock the laser to the sideband of the other laser
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| 9. |
- Gevorgian, Spartak, 1948, et al.
(författare)
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Optical electromagnetic wave generator
- 2001
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Microwaves are generated by heterodyning the outputs of two or more optical lasers which have differing central frequencies to produce beat frequencies in the microwave range. One of the beat frequencies is used to modulate the output of at least one of the lasers so as to produce sidebands which differ from the central frequency by an integral number of the sideband frequency. Each laser is connected to one of the other lasers by a weak optical link to optically injection lock the laser to the sideband of the other laser
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| 10. |
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