| 1. |
- Bourdieu, Pierre, et al.
(författare)
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Leve idrottspedagogiken : En vänbok tillägnad Lars-Magnus Engström
- 2005
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Vem ägnar sig åt idrott? Vilken betydelse har fritiden i barns och ungdomars liv? Vad innebär hälsa i skolämnet idrott och hälsa?Leve idrottspedagogiken! tillägnas Lars-Magnus Engström. Texterna i boken speglar delar av det idrottspedagogiska forskningsområdet i Sverige, vars framväxt Lars-Magnus Engström varit den främste företrädaren för. Läsaren får här ta del av exempelvis idrottskulturen, fritidskulturen och skolans ämne idrott och hälsa. Genomgående handlar texterna om villkoren för barns och ungdomars deltagane och om de olika lärprocesser som sker i anslutning till idrottsutövning.Lars-Magnus Engström har gjort betydande insatser som forskare och lärare samt som professor vid Lärarhögskolan i Stockholm och vid Gymnastik- och idrottshögskolan. I snart fyrtion år har han arbetat med studier kring påverkans- och lärprocesser i idrott. Hans forskning har främst kretsat kring människors idrottsvanor och vilka som utvecklar en fysiskt aktiv livsstil. Idrotts- och motionsutövningar ger både ett så kallat egenvärde och investeringsvärde. Med dessa begrepp bland många andra har Lars-Magnus Engström bidragit till en fördjupad vetenskaplig förståelse av idrottskulturen.De flesta författarna har eller har haft Lars-Magnus Engström som handledare och tillhör forskningsgruppen för pedagogik, idrott och fritidskultur. Redaktörer för boken är Karin Redelius och Håkan Larsson.
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| 2. |
- Hashemi, Jamileh, et al.
(författare)
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Molecular Characterization of Acquired Tolerance of Tumor Cells to Picropodophyllin (PPP)
- 2011
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 6:3, s. e14757-
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Tidskriftsartikel (refereegranskat)abstract
- Background: Picropodophyllin (PPP) is a promising novel anti-neoplastic agent that efficiently kills tumor cells in vitro and causes tumor regression and increased survival in vivo. We have previously reported that PPP treatment induced moderate tolerance in two out of 10 cell lines only, and here report the acquired genomic and expression alterations associated with PPP selection over 1.5 years of treatment. Methodology/Principal Findings: Copy number alterations monitored using metaphase and array-based comparative genomic hybridization analyses revealed largely overlapping alterations in parental and maximally tolerant cells. Gain/amplification of the MYC and PVT1 loci in 8q24.21 were verified on the chromosome level. Abnormalities observed in connection to PPP treatment included regular gains and losses, as well as homozygous losses in 10q24.1-q24.2 and 12p12.3-p13.2 in one of the lines and amplification at 5q11.2 in the other. Abnormalities observed in both tolerant derivatives include amplification/gain of 5q11.2, gain of 11q12.1-q14.3 and gain of 13q33.3-qter. Using Nexus software analysis we combined the array-CGH data with data from gene expression profilings and identified genes that were altered in both inputs. A subset of genes identified as downregulated (ALDH1A3, ANXA1, TLR4 and RAB5A) or upregulated (COX6A1, NFIX, ME1, MAPK and TAP2) were validated by siRNA in the tolerant or parental cells to alter sensitivity to PPP and confirmed to alter sensitivity to PPP in further cell lines. Conclusions: Long-term PPP selection lead to altered gene expression in PPP tolerant cells with increase as well as decrease of genes involved in cell death such as PTEN and BCL2. In addition, acquired genomic copy number alterations were observed that were often reflected by altered mRNA expression levels for genes in the same regions.
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| 3. |
- Inzunza, Jose, et al.
(författare)
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Selective insulin-like growth factor-I antagonist inhibits mouse embryo development in a dose-dependent manner
- 2010
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Ingår i: Fertility and Sterility. - : Elsevier BV. - 0015-0282 .- 1556-5653. ; 93:8, s. 2621-2626
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To study the role of a synthetic insulin-like growth factor-I receptor (IGF-IR) antagonist, picropodophyllin, for mouse preimplantation embryo development in vivo and in vitro. DESIGN: In vitro and in vivo study. SETTING: Hospital-based research unit. ANIMALS: FVB/N mice and mouse embryos. INTERVENTION(S): The effect of picropodophyllin in mouse embryo development in vivo and in vitro, immunohistochemistry, ELISA, polymerase chain reaction. MAIN OUTCOME MEASURE(S): Embryo development, presence of IGF-IR, messenger RNA expression, IGF-I synthesis. RESULT(S): The effect of picropodophyllin on embryo development in vitro and in vivo was not reversible. Mice treated with picropodophyllin 1 to 3 days after mating had a reduced number of blastocysts, 40.5% versus 78.8%, and a higher number of embryos with delayed development, 48.6% versus 11.5%. Insulin-like growth factor-IR protein is present in both phosphorylated and nonphosphorylated form at all stages of embryo development. The relative IGF-IR messenger RNA expression was highest in the oocyte and reduced during development to blastocyst stage. Insulin-like growth factor-I in culture media was reduced after picropodophyllin treatment. CONCLUSION(S): We conclude that IGF-I has an important role in normal mouse embryo development and that its receptor plays an essential role in the embryonic genome activation process.
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| 4. |
- Severinsson, Emelie
(författare)
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Experimental studies on ErbB targeted therapy in malignant melanoma
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Malignant melanoma has one of the fastest increasing incidences among the different types of cancer in the Western world. This raise can partly be ascribed to the change in sun habits that has taken place during the last decades, since the major external risk factor for melanoma is exposure to ultraviolet radiation. In the case of patients with early stages of melanoma, the prognosis is usually good and the disease may be cured by surgery alone. However, with conventional anti-cancer treatments, patients diagnosed with unresectable or metastatic melanoma have a very low 5-year survival rate ranging from less than 10 percent to about 20 percent, depending on the location and extent of metastatic spread. Despite the development of novel promising targeted drugs, such as the immunomodulating antibody ipilimumab and the B-raf inhibitor vemurafenib, that have been shown to significantly extend patient survival, there is still an urgent need for new and improved treatment strategies which can further increase the survival of patients with advanced malignant melanoma.The aim of this thesis was to investigate the anti-tumor effect of two different tyrosine kinase inhibitors (TKIs), gefitinib and canertinib, on human malignant melanoma cell lines with wild-type BRAF and NRAS. We investigated the effect of these two drugs on cell proliferation, survival and on the ErbB1-4 receptor phosphorylation, as well as the downstream signaling molecules Akt, Erk1/2 and Stat3. We also established a melanoma cell line resistant to gefitinib treatment and studied the resistance mechanisms developed by the cells.The aim of this thesis was to investigate the anti-tumor effect of two different tyrosine kinase inhibitors (TKIs), gefitinib and canertinib, on human malignant melanoma cell lines with wild-type BRAF and NRAS. We investigated the effect of these two drugs on cell proliferation, survival and on the ErbB1-4 receptor phosphorylation, as well as the downstream signaling molecules Akt, Erk1/2 and Stat3. We also established a melanoma cell line resistant to gefitinib treatment and studied the resistance mechanisms developed by the cells.In conclusion, gefitinib and canertinib display promising anti-tumor effects on ErbB-expressing malignant melanoma and might be used in future studies in combination with conventional chemotherapy or other targeted therapies in the treatment of malignant melanoma patients not harboring BRAF or NRAS mutations.
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| 5. |
- Östrand, Fredrik, et al.
(författare)
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Stereoisomeric composition of the sex pheromone of the pine sawfly Microdiprion pallipes (Hym., Diprionidae)
- 2003
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Ingår i: Chemoecology. - : Springer Science and Business Media LLC. - 0937-7409 .- 1423-0445. ; 13:3, s. 155-162
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Tidskriftsartikel (refereegranskat)abstract
- The basic chemical structure of the sex pheromone of the pine sawfly Microdiprion pallipes (Fallen) has earlier been identified as the propionate ester of (2S,3S,7 R/S,11 R/S)/(2R,3R,7 R/S,11 R/S)-3,7,11-trimethyl-2-tridecanol. We now report the results from further investigations on the male response to individual stereoisomers and to blends of stereoisomers, both in electroantennographic (EAG) recordings and in field trapping experiments. We also present our attempts to determine the stereochemistry of the compounds present in females of M. pallipes. By comparing gas chromatograms and mass spectra obtained from natural extracts with those from synthetic compounds it was found that the females contain one or more of the four (2S,3S,7 R/S,11 R/S)-3,7,11-trimethyl-2-tridecanol isomers (SS++-1). The active pheromone component is the corresponding propionate ester 2. In EAG experiments, males responded most strongly to five propionate ester samples, namely two four-isomer blends: SS++-2 and SR++-2, and three individual stereoisomers: SSSR-, SRRR- and SRSR-2. In a series of field trapping experiments it was found that males were attracted to the SR++-2 four-isomer blend and to the individual isomer SSSR-2. Based on the EAG-recordings and field responses of males and the stereoisomers found in the females, we suggest that the propionate ester of (2S,3S,7S,11R)-3,7,11-trimethyl-2-tridecanol (SSSR-2) is used as a main component of the sex pheromone in M. pallipes. Apparently the males react to other stereoisomers in addition to that or those produced by the females.
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| 6. |
- Abrahamsson, Olle, 1988-
(författare)
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On Aggregation and Dynamics of Opinions in Complex Networks
- 2024
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis studies two problems defined on complex networks, of which the first explores a conceivable extension of structural balance theory and the other concerns convergence issues in opinion dynamics. In the first half of the thesis we discuss possible definitions of structural balance conditions in a network with preference orderings as node attributes. The main result is that for the case with three alternatives (A, B, C) we reduce the (3!)3 = 216 possible configurations of triangles to 10 equivalence classes, and use these as measures of balance of a triangle towards possible extensions of structural balance theory. Moreover, we derive a general formula for the number of equivalent classes for preferences on n alternatives. Finally, we analyze a real-world data set and compare its empirical distribution of triangle equivalence classes to a null hypothesis in which preferences are randomly assigned to the nodes. The second half of the thesis concerns an opinion dynamics model in which each agent takes a random Bernoulli distributed action whose probability is updated at each discrete time step, and we prove that this model converges almost surely to consensus. We also provide a detailed critique of a claimed proof of this result in the literature. We generalize the result by proving that the assumption of irreducibility in the original model is not necessary. Furthermore, we prove as a corollary of the generalized result that the almost sure convergence to consensus holds also in the presence of a fully stubborn agent which never changes its opinion. In addition, we show that the model, in both the original and generalized cases, converges to consensus also in rth moment.
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| 7. |
- Abrahamsson, Olle, et al.
(författare)
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Opinion Dynamics with Random Actions and a Stubborn Agent
- 2019
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Ingår i: CONFERENCE RECORD OF THE 2019 FIFTY-THIRD ASILOMAR CONFERENCE ON SIGNALS, SYSTEMS & COMPUTERS. - : IEEE. - 9781728143002 ; , s. 1486-1490
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Konferensbidrag (refereegranskat)abstract
- We study opinion dynamics in a social network with stubborn agents who influence their neighbors but who themselves always stick to their initial opinion. We consider first the well-known DeGroot model. While it is known in the literature that this model can lead to consensus even in the presence of a stubborn agent, we show that the same result holds under weaker assumptions than has been previously reported. We then consider a recent extension of the DeGroot model in which the opinion of each agent is a random Bernoulli distributed variable, and by leveraging on the first result we establish that this model also leads to consensus, in the sense of convergence in probability, in the presence of a stubborn agent. Moreover, all agents opinions converge to that of the stubborn agent.
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| 8. |
- Abrahamsson, Olle, et al.
(författare)
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Strong Convergence of a Random Actions Model in Opinion Dynamics
- 2024
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Ingår i: IEEE TRANSACTIONS ON SIGNAL AND INFORMATION PROCESSING OVER NETWORKS. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 2373-776X. ; 10, s. 147-161
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Tidskriftsartikel (refereegranskat)abstract
- We study an opinion dynamics model in which each agent takes a random Bernoulli distributed action whose probability is updated at each discrete time step, and we prove that this model converges almost surely to consensus. We also provide a detailed critique of a claimed proof of this result in the literature. We generalize the result by proving that the assumption of irreducibility in the original model is not necessary. Furthermore, we prove as a corollary of the generalized result that the almost sure convergence to consensus holds also in the presence of a stubborn agent which never changes its opinion. In addition, we show that the model, in both the original and generalized cases, converges to consensus also in $r$th mean.
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| 9. |
- Abrahamsson, Olle, et al.
(författare)
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Structural Balance Considerations for Networks with Preference Orders as Node Attributes
- 2022
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Ingår i: 2022 56TH ASILOMAR CONFERENCE ON SIGNALS, SYSTEMS, AND COMPUTERS. - : IEEE. - 9781665459068 - 9781665459075 ; , s. 1255-1261
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Konferensbidrag (refereegranskat)abstract
- We discuss possible definitions of structural balance conditions in a network with preference orderings as node attributes. The main result is that for the case with three alternatives (A, B, C) we reduce the (3!)(3) = 216 possible configurations of triangles to 10 equivalence classes, and use these as measures of balance of a triangle towards possible extensions of structural balance theory. Moreover, we derive a general formula for the number of equivalent classes for preferences on n alternatives. Finally, we analyze a real-world data set and compare its empirical distribution of triangle equivalence classes to a null hypothesis in which preferences are randomly assigned to the nodes.
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| 10. |
- Ahlberg, Per, et al.
(författare)
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Geological fieldwork in the Kirwanveggen area
- 1992
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Ingår i: Swedish Antarctic research programme : a cruise report. 1991/92, Dronning Maud Land, Livingston Island, South Georgia. - 9197076988 ; , s. 13-21
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Bokkapitel (refereegranskat)
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