| 1. |
- Chirumalla, Koteshwar, et al.
(författare)
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Knowledge Sharing Across Boundaries : Web 2.0 and Product-Service System Development
- 2011
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Ingår i: 3rd International Conference on Research into Design ICoRD'11. - Bangalore, India : Research Publishing Services. - 9789810877217
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Konferensbidrag (refereegranskat)abstract
- In recent years there has been a growing interest among product development organizations to capitalize on engineering knowledge as their core competitive advantage for innovation. Capturing, storing, retrieval, sharing and reusing of engineering knowledge from a wide range of enterprise memory systems have become crucial activities of knowledge management practice in competitive organizations. In light of a changing and dynamic enterprise definition, including a move towards Product-Service System (PSS) development, this paper discusses some of the limitations of current enterprise systems in reusing engineering knowledge across functional and corporate boundaries. Further, the paper illustrates how Web 2.0-based collaborative technologies can leverage cross-functional knowledge for new PSS development projects through an open, bottom-up, and collective sense-making approach to knowledge management.
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| 2. |
- Ericson, Åsa, et al.
(författare)
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Need driven product development in team-based projects
- 2007
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Ingår i: Design for society. - Cité des Sciences et de l'industrie, Paris, France.
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Konferensbidrag (refereegranskat)abstract
- In this paper, practical activities of Needfinding - an intertwined approach to identifying needs and to visualizing idea concepts in early design - are described and discussed. This is done primarily to gain an increased understanding of the various representations of user needs that are fed into the fuzzy front-end activities of team-based product innovation projects. The empirical basis comes from a study of an eight-month collaborative product development project, performed under realistic conditions by MSc students in close collaboration with their client. Focusing closely on customers and their needs is encouraged within the conceptual framework of Integrated Product Development and is increasingly highlighted as a key enabler in the design of truly innovative products. Despite the fact that identified customer needs are considered as the initial and primary input into such an innovation process, it can be argued that the design teams do not commonly have a sufficient understanding of customer needs and they do not normally interact with customers in their environment. Besides focusing on measurable aspects of user behaviour and requirements, a traditional approach to identifying and managing customer needs usually includes several interpretive stages before being handed over to the design team. In the context of innovative products, the identification and definition of customers and their needs is a non-trivial and difficult exercise. It involves, we suggest, not only Needfinding but also the definition of ‘those who might need the product’, users and customers to co-evolve iteratively in the early phases of design.
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| 3. |
- Ericson, Åsa, et al.
(författare)
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Need driven product development in team-based projects
- 2007
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Ingår i: Design for society. - Paris.
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Konferensbidrag (refereegranskat)abstract
- In this paper, practical activities of needfinding - an intertwined approach to identifying needs and to visualizing idea concepts in early design - are described and discussed. This is done primarily to gain an increased understanding of the various representations of user needs that are fed into the fuzzy front-end activities of team-based product innovation projects. The empirical basis comes from a study of an eight-month collaborative product development project, performed under realistic conditions by MSc students in close collaboration with their client.Focusing closely on customers and their needs is encouraged within the conceptual framework of Integrated Product Development and is increasingly highlighted as a key enabler in the design of truly innovative products. Despite the fact that identified customer needs are considered as the initial and primary input into such an innovation process, it can be argued that the design teams do not commonly have a sufficient understanding of customer needs and they do not normally interact with customers in their environment. Besides focusing on measurable aspects of user behaviour and requirements, a traditional approach to identifying and managing customer needs usually includes several interpretive stages before being handed over to the design team. In the context of innovative products, the identification and definition of customers and their needs is a non-trivial and difficult exercise. It involves, we suggest, not only needfinding but also the definition of ‘those who might need the product’, users and customers to co-evolve iteratively in the early phases of design.
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| 4. |
- Abarenkov, Kessy, et al.
(författare)
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Annotating public fungal ITS sequences from the built environment according to the MIxS-Built Environment standard – a report from a May 23-24, 2016 workshop (Gothenburg, Sweden)
- 2016
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Ingår i: MycoKeys. - : Pensoft Publishers. - 1314-4057 .- 1314-4049. ; 16, s. 1-15
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Tidskriftsartikel (refereegranskat)abstract
- Recent molecular studies have identified substantial fungal diversity in indoor environments. Fungi and fungal particles have been linked to a range of potentially unwanted effects in the built environment, including asthma, decay of building materials, and food spoilage. The study of the built mycobiome is hampered by a number of constraints, one of which is the poor state of the metadata annotation of fungal DNA sequences from the built environment in public databases. In order to enable precise interrogation of such data – for example, “retrieve all fungal sequences recovered from bathrooms” – a workshop was organized at the University of Gothenburg (May 23-24, 2016) to annotate public fungal barcode (ITS) sequences according to the MIxS-Built Environment annotation standard (http://gensc.org/mixs/). The 36 participants assembled a total of 45,488 data points from the published literature, including the addition of 8,430 instances of countries of collection from a total of 83 countries, 5,801 instances of building types, and 3,876 instances of surface-air contaminants. The results were implemented in the UNITE database for molecular identification of fungi (http://unite.ut.ee) and were shared with other online resources. Data obtained from human/animal pathogenic fungi will furthermore be verified on culture based metadata for subsequent inclusion in the ISHAM-ITS database (http://its.mycologylab.org).
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| 5. |
- Abarenkov, Kessy, et al.
(författare)
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The UNITE database for molecular identification and taxonomic communication of fungi and other eukaryotes: sequences, taxa and classifications reconsidered
- 2024
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Ingår i: Nucleic Acids Research. - 0305-1048 .- 1362-4962. ; 52:D1, s. D791-D797
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Tidskriftsartikel (refereegranskat)abstract
- UNITE (https://unite.ut.ee) is a web-based database and sequence management environment for molecular identification of eukaryotes. It targets the nuclear ribosomal internal transcribed spacer (ITS) region and offers nearly 10 million such sequences for reference. These are clustered into similar to 2.4M species hypotheses (SHs), each assigned a unique digital object identifier (DOI) to promote unambiguous referencing across studies. UNITE users have contributed over 600 000 third-party sequence annotations, which are shared with a range of databases and other community resources. Recent improvements facilitate the detection of cross-kingdom biological associations and the integration of undescribed groups of organisms into everyday biological pursuits. Serving as a digital twin for eukaryotic biodiversity and communities worldwide, the latest release of UNITE offers improved avenues for biodiversity discovery, precise taxonomic communication and integration of biological knowledge across platforms. Graphical Abstract
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| 6. |
- Alderson, Helen V., et al.
(författare)
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FGF-23 and Osteoprotegerin but not Fetuin-A are associated with death and enhance risk prediction in non-dialysis chronic kidney disease stages 3-5
- 2016
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Ingår i: Nephrology (Carlton. Print). - : Wiley. - 1320-5358 .- 1440-1797. ; 21:7, s. 566-573
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Tidskriftsartikel (refereegranskat)abstract
- AIM: Numerous biomarkers have been shown to associate with clinical endpoints in chronic kidney disease (CKD). There is limited evidence whether biomarkers improve risk prediction in relation to clinical outcomes. Our study investigates whether a small suite of key chronic kidney disease-mineral and bone disorder biomarkers could be used to enhance risk assessment in CKD.METHODS: Fetuin-A, fibroblast growth factor-23 and osteoprotegerin were measured on baseline plasma samples from 463 patients recruited to the Chronic Renal Insufficiency Standards Implementation Study. The biomarkers were analysed in relation to progression to end stage kidney disease, death and major cardiovascular events.RESULTS: Over a median follow up of 46 months (interquartile range 21-69), fibroblast growth factor-23 was associated with risk for renal replacement therapy (hazard ratio (HR) 1.35, P = 0.05, 95% confidence interval (CI) 1.001-1.820), cardiovascular events (HR 1.74 P < 0.001, 95% CI 1.303-1.305) and death (HR 1.4 P = 0.005, 95% CI 1.109-1.767). Osteoprotegerin was associated with risk for death (HR 1.06, P = 0.03, 95% CI 1.006-1.117). There was no clear association between Fetuin-A and any of the clinical endpoints. The addition of biomarkers to risk models led to marginal improvement in model discrimination and reclassification.CONCLUSION: Biomarkers are often associated with clinical endpoints, and we observed such associations in our study of patients with advanced CKD. However, the markers analysed in our study were of limited benefit in improving the prediction of these outcomes. Any extra information biomarkers may provide to improve risk prediction in clinical practice needs to be carefully balanced against the potential cost of these tools.
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| 7. |
- Alderson, Helen V, et al.
(författare)
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Longitudinal change in c-terminal fibroblast growth factor 23 and outcomes in patients with advanced chronic kidney disease
- 2021
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Ingår i: BMC Nephrology. - : BioMed Central (BMC). - 1471-2369. ; 22:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Fibroblast growth factor23 (FGF23) is elevated in CKD and has been associated with outcomes such as death, cardiovascular (CV) events and progression to Renal Replacement therapy (RRT). The majority of studies have been unable to account for change in FGF23 over time and those which have demonstrate conflicting results. We performed a survival analysis looking at change in c-terminal FGF23 (cFGF23) over time to assess the relative contribution of cFGF23 to these outcomes.METHODS: We measured cFGF23 on plasma samples from 388 patients with CKD 3-5 who had serial measurements of cFGF23, with a mean of 4.2 samples per individual. We used linear regression analysis to assess the annual rate of change in cFGF23 and assessed the relationship between time-varying cFGF23 and the outcomes in a cox-regression analysis.RESULTS: Across our population, median baseline eGFR was 32.3mls/min/1.73m2, median baseline cFGF23 was 162 relative units/ml (RU/ml) (IQR 101-244 RU/mL). Over 70 months (IQR 53-97) median follow-up, 76 (19.6%) patients progressed to RRT, 86 (22.2%) died, and 52 (13.4%) suffered a major non-fatal CV event. On multivariate analysis, longitudinal change in cFGF23 was significantly associated with risk for death and progression to RRT but not non-fatal cardiovascular events.CONCLUSION: In our study, increasing cFGF23 was significantly associated with risk for death and RRT.
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| 8. |
- Benaim, Andre, et al.
(författare)
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Becoming An Innovative Company : Assessing An Organization’s Innovation Capability From The Perspective Of A Team
- 2014
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Konferensbidrag (refereegranskat)abstract
- Literature points out the need for companies to innovate continuously. Such need requires that companies develop capacities to exploit and improve current work as well as to develop and explore more radical opportunities. This paper is a case study that investigates the innovation capabilities of a multinational manufacturing company by interviewing a group that is mandate to support the development of those capabilities. The data was collected by semi-structured interviews, which were based on the categories of a framework previously developed. The findings speak about the importance of setting clear processes for continuation and implementation of ideas, adequate allocation of resources and management support. The discussion and conclusion are about the importance of the integration of efforts in different organizational levels and some of the future challenges integrating the innovation efforts into a natural way of working.
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| 9. |
- Benaim, Andre, et al.
(författare)
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Building a pathway for innovation : Lessons learned from developing an online platform
- 2014
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Ingår i: Proceedings of NordDesign 2014 Conference, NordDesign 2014. - Eespo, Finland : Aalto University. - 9781904670582 ; , s. 662-669
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Konferensbidrag (refereegranskat)abstract
- Companies are constantly being pressured to innovate in order to stay competitive in the short run and have new offerings in the long run. One way of boosting innovation is to develop idea support systems that go beyond the traditional methods and tools. Through a qualitative study, this paper explores the lessons learned from developing an online platform for idea generation, and discusses it in terms of innovation process, climate, and capabilities. The results show that the platform itself is not enough for innovation. The structure and work processes around the platform are as important, which implies the need to design processes and procedures that allow an idea to develop, providing, focus, idea feedback and role clarity.
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| 10. |
- Benaim, Andre, et al.
(författare)
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The implementation of Innovation Metrics: A case study
- 2015
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Ingår i: Proceedings of the 20th International Conference on Engineering Design. - : The Design Society. - 2220-4334 .- 2220-4342. - 9781904670711 ; 8, s. 213-224
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Konferensbidrag (refereegranskat)abstract
- The paper explores the implementation process of an innovation measuring system prototype to support a heavy machinery multinational company to secure their innovative capability. In general, companies recognize the importance of becoming innovative to become, or remain, competitive on a global market. The case company decided to pilot a metric system that corresponds to the crucial factors to secure innovative capability and work with the stepwise improvement based on the assessment results. The methods are based on design-research approach and participatory action research. Interviews, surveys and observation were used, as well as, workshops were conducted to develop and follow up the implementation innovation measuring system. The findings explore topics and open questions related to metric selection, purpose and use of the selected indicators, as well as challenges related to the implementation of the metric system. Some of the conclusions question the viability of measuring project teams, as well as, it suggests the need for further research to clarify whether team metrics need to be develop in parallel to organizational ones.
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