| 1. |
- Barjesteh van Waalwijk van Doorn-Khosrovani, Sahar, et al.
(författare)
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PCM4EU and PRIME-ROSE : Collaboration for implementation of precision cancer medicine in Europe
- 2024
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Ingår i: Acta Oncologica. - 1651-226X .- 1651-226X. ; 63, s. 385-391
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: In the two European Union (EU)-funded projects, PCM4EU (Personalized Cancer Medicine for all EU citizens) and PRIME-ROSE (Precision Cancer Medicine Repurposing System Using Pragmatic Clinical Trials), we aim to facilitate implementation of precision cancer medicine (PCM) in Europe by leveraging the experience from ongoing national initiatives that have already been particularly successful. PATIENTS AND METHODS: PCM4EU and PRIME-ROSE gather 17 and 24 partners, respectively, from 19 European countries. The projects are based on a network of Drug Rediscovery Protocol (DRUP)-like clinical trials that are currently ongoing or soon to start in 11 different countries, and with more trials expected to be established soon. The main aims of both the projects are to improve implementation pathways from molecular diagnostics to treatment, and reimbursement of diagnostics and tumour-tailored therapies to provide examples of best practices for PCM in Europe. RESULTS: PCM4EU and PRIME-ROSE were launched in January and July 2023, respectively. Educational materials, including a podcast series, are already available from the PCM4EU website (http://www.pcm4eu.eu). The first reports, including an overview of requirements for the reimbursement systems in participating countries and a guide on patient involvement, are expected to be published in 2024. CONCLUSION: European collaboration can facilitate the implementation of PCM and thereby provide affordable and equitable access to precision diagnostics and matched therapies for more patients. ble from the PCM4EU website (http://www.pcm4eu.eu). The first reports, including an overview of requirements for the reimbursement systems in participating countries and a guide on patient involvement, are expected to be published in 2024. CONCLUSION: European collaboration can facilitate the implementation of PCM and thereby provide affordable and equitable access to precision diagnostics and matched therapies for more patients.
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| 2. |
- Edsjö, Anders, et al.
(författare)
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Precision cancer medicine : Concepts, current practice, and future developments
- 2023
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Ingår i: Journal of Internal Medicine. - 0954-6820 .- 1365-2796. ; 294:4, s. 455-481
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Forskningsöversikt (refereegranskat)abstract
- Precision cancer medicine is a multidisciplinary team effort that requires involvement and commitment of many stakeholders including the society at large. Building on the success of significant advances in precision therapy for oncological patients over the last two decades, future developments will be significantly shaped by improvements in scalable molecular diagnostics in which increasingly complex multilayered datasets require transformation into clinically useful information guiding patient management at fast turnaround times. Adaptive profiling strategies involving tissue- and liquid-based testing that account for the immense plasticity of cancer during the patient's journey and also include early detection approaches are already finding their way into clinical routine and will become paramount. A second major driver is the development of smart clinical trials and trial concepts which, complemented by real-world evidence, rapidly broaden the spectrum of therapeutic options. Tight coordination with regulatory agencies and health technology assessment bodies is crucial in this context. Multicentric networks operating nationally and internationally are key in implementing precision oncology in clinical practice and support developing and improving the ecosystem and framework needed to turn invocation into benefits for patients. The review provides an overview of the diagnostic tools, innovative clinical studies, and collaborative efforts needed to realize precision cancer medicine.
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| 3. |
- Engstrøm, Thomas, et al.
(författare)
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Danegaptide for primary percutaneous coronary intervention in acute myocardial infarction patients : A phase 2 randomised clinical trial
- 2018
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Ingår i: Heart. - : BMJ. - 1355-6037 .- 1468-201X. ; 104:19, s. 1593-1599
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: Reperfusion immediately after reopening of the infarct-related artery in ST-segment elevation myocardial infarction (STEMI) may cause myocardial damage in addition to the ischaemic insult (reperfusion injury). The gap junction modulating peptide danegaptide has in animal models reduced this injury. We evaluated the effect of danegaptide on myocardial salvage in patients with STEMI. Methods: In addition to primary percutaneous coronary intervention in STEMI patients with thrombolysis in myocardial infarction flow 0-1, single vessel disease and ischaemia time less than 6 hours, we tested, in a clinical proof-of-concept study, the therapeutic potential of danegaptide at two-dose levels. Primary outcome was myocardial salvage evaluated by cardiac MRI after 3 months. Results: From November 2013 to August 2015, a total of 585 patients were randomly enrolled in the trial. Imaging criteria were fulfilled for 79 (high dose), 80 (low dose) and 84 (placebo) patients eligible for the per-protocol analysis. Danegaptide did not affect the myocardial salvage index (danegaptide high (63.9±14.9), danegaptide low (65.6±15.6) and control (66.7±11.7), P=0.40), final infarct size (danegaptide high (19.6±11.4 g), danegaptide low (18.6±9.6 g) and control (21.4±15.0 g), P=0.88) or left ventricular ejection fraction (danegaptide high (53.9%±9.5%), danegaptide low (52.7%±10.3%) and control (52.1%±10.9%), P=0.64). There was no difference between groups with regard to clinical outcome. Conclusions: Administration of danegaptide to patients with STEMI did not improve myocardial salvage. Trial registration number: NCT01977755; Pre-results.
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| 4. |
- Lassen, Ulrik Hjort, 1979
(författare)
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Craftmen's Practice of Timber Framing Methods
- 2009
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Ingår i: Proceedings of the International Symposium on Timber Structures, 25-27 June, Istanbul, Turkey. "Timber Structures from Antiquity to the Present" - Edited by: John CHILTON and Ihsan MUNGAN. - 9789758574254 ; , s. 101-112
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Konferensbidrag (refereegranskat)abstract
- In this paper I have surveyed and classified the different transferring methods used for adjusting irregularly sized timber. In contrary to the research that exists in this field that has mostly focused on buildings and construction types, I have tried to classify and explain the methods that I have identified keeping the focus on what actually happens in the practical situation. It can be seen as an attempt to re-establish the craftsman’s know-how in hands on restoration and reconstruction. The empirical material constists of my own carpentry experience and of participation in practical restoration and reconstruction projects in Danish, Norwegian, French, English, Japanese and American timber-frame traditions. I have also used historical and contemporary literature and handbooks for carpenters that involve methods of scribing irregularly sized timber. The preliminary classification of the transferring methods is followed by a visual description of each identified procedure and a short analysis of effi ciency, workplace arrangements, context of tradition, tools and markings for the different methods. Despite advanced power tools, CAD-drawings and prefabrication, every experienced timber framer has undoubtedly found himself in a situation when the transferring methods are effi cient and therefore needed. Even today there will always be situations that require a craftsman’s practice of timber framing methods.
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| 5. |
- Lassen, Ulrik Hjort, 1979
(författare)
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Hantverk på Japanska? Om att mötas och utbildas i handling
- 2011
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Ingår i: Bygnadskultur. - 0348-6885. ; :2:2011, s. 26-30
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Vad skiljer en japansk stolpverkskonstruktion från en norsk? Vilka timringstraditioner förekommer på den engelska landsbygden? Och hur gör man för att lära av varandra när man samtidigt ska bygga ett hus? Det är frågor som hantverksdoktoranden Ulrik Hjort Lassen numera kan besvara. I den här artikeln berättar han om tre internationella arbetsseminarier för hantverkare som han har haft chansen att delta i.
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| 6. |
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| 7. |
- Lassen, Ulrik Hjort, 1979
(författare)
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Piquer au Plomb
- 2014
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Ingår i: Hantverkslaboratoriets filmkanal på Youtube.
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Piquer au Plomb - "at tilridse med loddet". En film av Ulrik Hjort Lassen. Filmen är en undervisningsinriktad beskrivning av en fransk metod för påmärkning av timmer och en del av Ulrik Hjort Lassens forskningsarbete i stolpverkskonstruktioner.
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| 8. |
- Lassen, Ulrik Hjort, 1979
(författare)
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Piquer au plomb - En undersögelse af en gammel byggeteknik
- 2007
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- An analytic study of the French timber framed three-aisled barn in Aclou, built in the 15th century, has shown that it is possible to reconstruct the original building process by means of knowledge of workmanship, of recise measuring and of digital documentation. This reconstruction has been an attempt to regard historical buildings as a result of a building process and not just as a historical monument. The focus of this study has been to find and to use the still existing traces and markings from the original building process as argumentation for a reconstruction, a description of the workmanship that lies behind the timber frame construction. It has been an attempt to make a scientific research of the intellectual part of the craft to show and to revive some of the simple but very efficient techniques and tools which were developed throughout the past thousand years, and which today mistakenly have slipped out of use.
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| 9. |
- Lassen, Ulrik Hjort, 1979, et al.
(författare)
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'Plumb Line scribe': Using multimedia to preserve traditional craft skills
- 2013
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Ingår i: Craft Research. - : Intellect. - 2040-4689 .- 2040-4697. ; 4:1, s. 31-52
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Tidskriftsartikel (refereegranskat)abstract
- The skills required in craft practice involve a high degree of tacit knowledge which is internalised and frequently difficult for the craft expert to articulate. Wood, a multimedia designer, has undertaken extensive research over the last 10 years seeking to understand the knowledge of skilled craftsmen and find methods of capturing it and passing it on. She has developed an elicitation strategy that employs an expert learner to uncover the skilled knowledge of master craftsmen, and a transmission strategy based on the concept of bridges to assist the design of learning resources for novices. The aim of this research was to investigate the possibility of combining the two roles defined in Wood’s research as an expert learner and designer. Lassen has used the techniques developed by Wood to record and transmit the skilled knowledge needed to make timber-framed buildings, knowledge that today is in danger of being lost. The focus of the study has been the procedure for scribing timbers which is a central part of the building process. Being a skilled carpenter, Lassen has acted as an expert learner, learning the skills of scribing through a combination of researching existing documentation, working with master craftsmen, and his own experimentation. He developed and tested a multimedia learning resource to provide ‘bridges’ for new learners to this knowledge. The outcome of the application of Wood’s elicitation and transmission strategy to plumb line scribing is a demonstration of the transferability of Wood’s methods within this new context. This is important because it reveals the potential for other craft practitioners to apply Wood’s methods to their own learning and teaching, and produce learning resources to provide bridges to their craft knowledge and preserve their unique skills.
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| 10. |
- Lassen, Ulrik Hjort, 1979
(författare)
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Practice-led research in timber framing methods
- 2012
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Ingår i: Hantverkslaboratoriet.
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- My research lies within the area of timber-framed constructions. As a carpenter I am interested in the working procedures involved in the practical building situation, and I focus on the part of the building process, situated between the idea of a construction and the cutting of the joinery. In this study it is called the ‘scribing’ process. This construction is a case study in my practice-led research, where it has been possible to apply working procedures in practical craft laborations. The aim of the study has been to test and compare different methods and solutions in the same construction, and to identify and analyse different parts of the building process that have an influence on the scribing process. It has been a way to take in the knowledge I have learned and found in different contexts, to improve my own skill level and to support the results of my research. The leading questions throughout the study have been: •Which parts of the building process have a direct influence on the scribing procedures? •Which principles form the basis of the scribing of timbers, when focusing on what is happening in the practical situation? •Which tools, skills and theoretical knowledge are necessary to be able to scribe a timber-framed construction?
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