| 1. |
- JOHANSSON, A, et al.
(författare)
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EFFECT OF WATER ON DIFFUSION AND IONIC-CONDUCTIVITY IN PEG AND LICF(3)SO(3)PEG(10)
- 1995
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Ingår i: JOURNAL OF PHYSICAL CHEMISTRY. - : AMER CHEMICAL SOC. ; 99:16
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The diffusion of the cation, the anion, and the polymer chain in the hydrated low molecular weight polymer electrolyte system LiCF(3)SO(3)PEG(10) has been studied by Li-7, F-19, and H-1 NMR, using the fringe field of a 7 T superconducting magnet. The sel
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| 2. |
- Lauenstein, A., et al.
(författare)
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Molecular dynamics simulation of an aqueous aluminium(III) chloride solution with three-body interactions
- 2000
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Ingår i: International Journal of Quantum Chemistry. - 0020-7608 .- 1097-461X. ; 80:05-apr, s. 892-906
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Tidskriftsartikel (refereegranskat)abstract
- A molecular dynamics simulation of a 0.28 molar aqueous AlCl3 solution was performed with the flexible Bopp, Jancso, and Heinzinger (BJH) model for water and a newly developed three-body potential for Al3+-(H2O)(2) interactions derived from ab initio calculations. The simulations extended over 25 ps at an average temperature of 300 K. The structural properties of the solution are discussed on the basis of radial distribution functions and the orientation of the water molecules. Dynamical properties and OH frequency shifts were calculated from autocorrelation functions for the hydration shells of the ions.
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| 3. |
- Poschke, Isabel C., et al.
(författare)
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The Outcome of Ex Vivo TIL Expansion Is Highly Influenced by Spatial Heterogeneity of the Tumor T-Cell Repertoire and Differences in Intrinsic In Vitro Growth Capacity between T-Cell Clones
- 2020
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Ingår i: Clinical Cancer Research. - : AMER ASSOC CANCER RESEARCH. - 1078-0432 .- 1557-3265. ; 26:16, s. 4289-4301
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: During our efforts to develop tumor-infiltrating lymphocyte (TIL) therapy to counter the devastating recurrence rate in patients with primary resectable pancreatic ductal adenocarcinoma (PDA), we found that PDA TILs can readily be expanded in vitro and that the majority of resulting TIL cultures show reactivity against the autologous tumor. However, the fraction of tumor-reactive T cells is low. We investigated to which extent this was related to the in vitro expansion. Experimental Design: We compared the clonal composition of TIL preparations before and after in vitro expansion using T-cell receptor (TCR) deep sequencing. Our findings for PDA were benchmarked to experiments with melanoma TILs. Results: We found that the TIL TCR repertoire changes dramatically during in vitro expansion, leading to loss of tumor-dominant T-cell clones and overgrowth by newly emerging T-cell clones that are barely detectable in the tumor. These changes are primarily driven by differences in the intrinsic in vitro expansion capacity of T-cell clones. Single-cell experiments showed an association between poor proliferative capacity and expression of markers related to antigen experience and dysfunction. Furthermore, we found that spatial heterogeneity of the TIL repertoire resulted in TCR repertoires that are greatly divergent between TIL cultures derived from distant tumor samples of the same patient. Conclusions: Culture-induced changes in clonal composition are likely to affect tumor reactivity of TIL preparations. TCR deep sequencing provides important insights into the factors that govern the outcome of in vitro TIL expansion and thereby a path toward optimization of the production of TIL preparations with high therapeutic efficacy.
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| 4. |
- Lauenstein, A, et al.
(författare)
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Chain mobility and cation coordination in the polymer electrolytes M[N(CF3SO2)(2)](2)PEOn with M=Mg, Ca, Sr, and Ba
- 1998
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Ingår i: JOURNAL OF PHYSICAL CHEMISTRY B. - : AMER CHEMICAL SOC. ; 102:35
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The poly(ethylene oxide)-based solid electrolytes M[N(CF3SO2)(2)](2)PEOn with M = Mg, Ca, Sr, and Ba and n = 6-24 have been examined with proton NMR spectroscopy, DSC, and X-ray diffraction to explore some of their dynamic and structural properties. Chan
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| 5. |
- Lauenstein, A, et al.
(författare)
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Ion coordination and chain mobility in La(CF3SO3)(3)PEOn studied with NMR spectroscopy
- 1997
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Ingår i: JOURNAL OF PHYSICAL CHEMISTRY B. - : AMER CHEMICAL SOC. ; 101:17
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The polymer electrolyte system La(CF3SO3)(3)PEOn has been examined with differential scanning calorimetry (DSC) and NMR spectroscopy in order to analyze some of its structural and dynamic properties. Above the glass transition temperature, the fully amor
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| 6. |
- Lauenstein, A, et al.
(författare)
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Water absorption by polymer electrolytes studied by NMR imaging
- 1998
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Ingår i: MACROMOLECULES. - : AMER CHEMICAL SOC. - 0024-9297. ; 31:12, s. 3886-3894
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Water diffusion into the polymer electrolytes (Pb, Zn)(CF3SO3)(2)(PEO)(n) leads to a dramatic increase of the ionic conductivity. Magnetic resonance imaging, MRI, has been used to study this water diffusion by one-dimensional mapping of properties such as
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