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- Aad, G, et al.
(författare)
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- 2015
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swepub:Mat__t
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- Rajewsky, N., et al.
(författare)
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LifeTime and improving European healthcare through cell-based interceptive medicine
- 2020
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Ingår i: Nature. - : Springer Nature. - 0028-0836 .- 1476-4687. ; 587:7834, s. 377-386
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Tidskriftsartikel (refereegranskat)abstract
- LifeTime aims to track, understand and target human cells during the onset and progression of complex diseases and their response to therapy at single-cell resolution. This mission will be implemented through the development and integration of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during progression from health to disease. Analysis of such large molecular and clinical datasets will discover molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. Timely detection and interception of disease embedded in an ethical and patient-centered vision will be achieved through interactions across academia, hospitals, patient-associations, health data management systems and industry. Applying this strategy to key medical challenges in cancer, neurological, infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade.
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- Lauwers, E., et al.
(författare)
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Potential human transmission of amyloid beta pathology: surveillance and risks
- 2020
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Ingår i: Lancet Neurology. - 1474-4422 .- 1474-4465. ; 19:10, s. 872-878
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Tidskriftsartikel (refereegranskat)abstract
- Studies in experimental animals show transmissibility of amyloidogenic proteins associated with prion diseases, Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. Although these data raise potential concerns for public health, convincing evidence for human iatrogenic transmission only exists for prions and amyloid beta after systemic injections of contaminated growth hormone extracts or dura mater grafts derived from cadavers. Even though these procedures are now obsolete, some reports raise the possibility of iatrogenic transmission of amyloid beta through putatively contaminated neurosurgical equipment. Iatrogenic transmission of amyloid beta might lead to amyloid deposition in the brain parenchyma and blood vessel walls, potentially resulting in cerebral amyloid angiopathy after several decades. Cerebral amyloid angiopathy can cause life-threatening brain haemorrhages; yet, there is no proof that the transmission of amyloid can also lead to Alzheimer's dementia. Large, long-term epidemiological studies and sensitive, cost-efficient tools to detect amyloid are needed to better understand any potential routes of amyloid beta transmission and to clarify whether other similar proteopathic seeds, such as tau or alpha-synuclein, can also be transferred iatrogenically.
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5. |
- Alessandro, B., et al.
(författare)
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Vector boson scattering : Recent experimental and theory developments
- 2018
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Ingår i: Reviews in Physics. - : Elsevier BV. - 2405-4283. ; 3, s. 44-63
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Tidskriftsartikel (refereegranskat)abstract
- This document summarises the talks and discussions happened during the VBSCan Split17 workshop, the first general meeting of the VBSCan COST Action network. This collaboration is aiming at a consistent and coordinated study of vector-boson scattering from the phenomenological and experimental point of view, for the best exploitation of the data that will be delivered by existing and future particle colliders.
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- Sjöberg, Jonas, 1964, et al.
(författare)
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Identification of Wiener–Hammerstein models: Two algorithms based on the best split of a linear model applied to the SYSID'09 benchmark problem
- 2012
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Ingår i: Control Engineering Practice. - : Elsevier BV. - 0967-0661. ; 20:11, s. 1119-1125
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes the identification of Wiener–Hammerstein models and two recently suggested algorithms are applied to the SYSID'09 benchmark data. The most difficult step in the identification process of such block-oriented models is to generate good initial values for the linear dynamic blocks so that local minima are avoided. Both of the considered algorithms obtain good initial estimates by using the best linear approximation (BLA) which can easily be estimated from data. Given the BLA, the two algorithms differ in the way the dynamics are separated into two linear parts. The first algorithm simply considers all possible splits of the dynamics. Each of the splits is used to initialize one Wiener–Hammerstein model using linear least-squares and the best performing model is selected. In the second algorithm, both linear blocks are initialized with the entire BLA model using basis function expansions of the poles and zeros of the BLA. This gives over-parameterized linear blocks and their order is decreased in a model reduction step. Both algorithms are explained and their properties are discussed. They both give good, comparable models on the benchmark data.
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