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Sökning: WFRF:(Lebech Anne Mette)

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1.
  • Adams, Yvonne, et al. (författare)
  • 3D blood-brain barrier-organoids as a model for Lyme neuroborreliosis highlighting genospecies dependent organotropism
  • 2023
  • Ingår i: ISCIENCE. - : CELL PRESS. - 2589-0042. ; 26:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Lyme neuroborreliosis (LNB), a tick-borne infection caused by spirochetes within the Borrelia burgdorferi sensu lato (s.L.) complex, is among the most prevalent bacterial central nervous system (CNS) infections in Europe and the US. Here we have screened a panel of low- passage B. burgdorferi s.l. isolates using a novel, human-derived 3D blood-brain barrier (BBB)-organoid model. We show that human-derived BBB-organoids support the entry of Borrelia spirochetes, leading to swelling of the organoids and a loss of their structural integrity. The use of the BBB-organoid model highlights the organotropism between B. burgdorferi s.l. genospecies and their ability to cross the BBB contributing to CNS infection.
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2.
  • Eikeland, Randi, et al. (författare)
  • Tick-borne diseases in the North Sea region-A comprehensive overview and recommendations for diagnostics and treatment
  • 2024
  • Ingår i: Ticks and Tick-borne Diseases. - : ELSEVIER GMBH. - 1877-959X .- 1877-9603. ; 15:2
  • Tidskriftsartikel (refereegranskat)abstract
    • As part of the NorthTick project, co -funded by the European Union through the European Regional Development Fund and the North Sea Region Programme, specialists in the field of tick -borne diseases from seven North Sea countries co-operated with patient organisations and governmental health care institutions to provide this comprehensive overview of diagnostics and treatment recommendations in the region for Lyme borreliosis, Borrelia miyamotoi infection, tick -borne encephalitis, human granulocytic anaplasmosis, rickettsiosis, neoehrlichiosis and babesiosis. The main conclusion is that the recommendations in these northern countries are essentially the same, with very few differences. This overview presents the current diagnostics and provides useful clinical guidance.
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