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| 2. |
- Locke, Adam E, et al.
(författare)
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Genetic studies of body mass index yield new insights for obesity biology.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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| 3. |
- Parks, Darcy, 1986-
(författare)
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The Sustainable City Becomes Climate-Smart : How Smart City Ideas Reshape Urban Environmental Governance
- 2018
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The idea of smart cities has become enormously popular during the past decade. Environmental governance is one issue in which smart city ideas seem to hold potential. However, there is an incredible variety in what it means for a city to be ‘smart’. For some, it involves the use of information and communication technology (ICT) to solve problems; for others, it has more to do with economic growth and city branding. Many social science researchers have criticised the idea of smart cities. They worry that it might allow multinational corporations to take control of municipal governance and lead to an undue focus on technological solutions to societal issues. However, only a few previous studies have examined the influence on urban environmental governance in practice. This thesis investigates the influence of smart city ideas on urban environmental governance through a study of Hyllie, a climate-smart city district in Malmö, Sweden. It applies a theoretical perspective based on science and technology studies and the concept of assemblage. It combines participant-observation of inter-organisational meetings, interviews with professionals and document analysis. This thesis contributes a more comprehensive picture of which actors influence the direction of the climate-smart city—beyond the usual suspects of municipal governments and multinational companies. Still, it shows how ICT-based smart city solutions have taken precedence in urban environmental governance at the expense of energy efficiency and renewable energy.
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| 4. |
- Åsberg, Cecilia, 1974-, et al.
(författare)
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Möt den posthumanistiska utmaningen
- 2012. - 1
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Ingår i: Posthumanistiska nyckeltexter. - Lund : Studentlitteratur. - 9144057474 - 9789144057477 ; , s. 29-45
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Den här boken introducerar några viktiga författare på samtidsaktuella teoriområden. Donna Haraway, Karen Barad, Rosi Braidotti, Michel Callon, Gilles Deleuze, Félix Guattari, Michel Serres och Annemarie Mol presenteras i boken, som också innehåller översatta texter av dessa namn. Boken ger en bakgrund till och en överblick över ett område i intensiv teoriutveckling. Här presenteras den så kallade materiella, posthumana eller ontologiska vändningen. Här kartläggs grunderna för olika posthumanistiska förhållningssätt till de både mänskliga och icke-mänskliga (djur, miljö, teknik) krafterna i vår värld så som de begreppsliggjorts inom filosofi, feministisk teori, kulturstudier och samhällsvetenskapliga studier av naturvetenskap, medicin och teknik. Genom lästips och en omfattande litteraturlista öppnar boken för fortsatta studier och vidare diskussioner. Avslutningsvis finns också en omfattande ordlista med viktiga nyckelbegrepp som i sig ger en introduktion till ett heterogent forskningsfält. Boken riktar sig till studenter, doktorander och andra nyfikna forskare inom olika tvärvetenskapliga eller disciplinära former av humaniora och samhällsvetenskap.
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| 5. |
- Åsberg, Cecilia, 1974-, et al.
(författare)
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Posthumanistisk Ordlista
- 2012. - 1
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Ingår i: Posthumanistiska nyckeltexter. - Lund, Sverige : Studentlitteratur. - 9789144057477 ; , s. 201-217
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Bokkapitel (refereegranskat)abstract
- Den här boken introducerar några viktiga författare på samtidsaktuella teoriområden. Donna Haraway, Karen Barad, Rosi Braidotti, Michel Callon, Gilles Deleuze, Félix Guattari, Michel Serres och Annemarie Mol presenteras i boken, som också innehåller översatta texter av dessa namn. Boken ger en bakgrund till och en överblick över ett område i intensiv teoriutveckling. Här presenteras den så kallade materiella, posthumana eller ontologiska vändningen. Här kartläggs grunderna för olika posthumanistiska förhållningssätt till de både mänskliga och icke-mänskliga (djur, miljö, teknik) krafterna i vår värld så som de begreppsliggjorts inom filosofi, feministisk teori, kulturstudier och samhällsvetenskapliga studier av naturvetenskap, medicin och teknik. Genom lästips och en omfattande litteraturlista öppnar boken för fortsatta studier och vidare diskussioner. Avslutningsvis finns också en omfattande ordlista med viktiga nyckelbegrepp som i sig ger en introduktion till ett heterogent forskningsfält. Boken riktar sig till studenter, doktorander och andra nyfikna forskare inom olika tvärvetenskapliga eller disciplinära former av humaniora och samhällsvetenskap.
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| 6. |
- Berndt, Sonja I., et al.
(författare)
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
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Tidskriftsartikel (refereegranskat)abstract
- Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
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| 7. |
- Doganova, Liliana, et al.
(författare)
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Valuation Studies and the Critique of Valuation
- 2014
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Ingår i: Valuation Studies. - : Linkoping University Electronic Press. - 2001-5992. ; 2:2, s. 87-96
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Dussauge, Isabelle, 1978-, et al.
(författare)
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On the Omnipresence, Diversity, and Elusiveness of Values in the Life Sciences
- 2013
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Konferensbidrag (refereegranskat)abstract
- Biomedicine – health care and the life sciences – are saturated with values. Valuations of life itself are intermingled with values such as scientific reputation, profitability, fairness, competition, and accessibility of care. Reciprocally, the practices of biomedicine produce values, for instance: public health, the preservation of endangered species, profitability of tamed animals for farming, usability of clinical data, or bodily autonomy.What sets this book apart from many of the dominant theoretical approaches to values (in economics, anthropology, sociology, philosophy, history) is that we take an interest not primarily in values as given entities, but rather as how they are enacted in practices. This leads us down an analytical route where values are seen as the outcome of work, where they are the result of a wide range of activities. Fairness, to take an example that often has currency in the provision of health care services, is thus seen as a value that is inseparable from the work evoking it. In an effort to chart a “value practices” approach to the concerns raised above, we aim to focus on how values are enacted: in actions, in technical practices, and in practices of valuation. Here we will provide some first parts of an outline for such an approach to the study of values as they are enacted in biomedicine. The exercise is rooted in an ambition to consider “values” as something to be explained and explored rather than as a given entity with explanatory power. In this we will try to account both how peoples’ actions draw on values, and how agents’ actions and reactions come to enact values.
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