| 1. |
- Cossarizza, A., et al.
(författare)
-
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
- 2019
-
Ingår i: European Journal of Immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 49:10, s. 1457-1973
-
Tidskriftsartikel (refereegranskat)abstract
- These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid the common errors that often undermine immunological data. Notably, there are comprehensive sections of all major immune cell types with helpful Tables detailing phenotypes in murine and human cells. The latest flow cytometry techniques and applications are also described, featuring examples of the data that can be generated and, importantly, how the data can be analysed. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid, all written and peer-reviewed by leading experts in the field, making this an essential research companion.
|
|
| 2. |
|
|
| 3. |
- Narayan, G., et al.
(författare)
-
LIGHT CURVES OF 213 TYPE Ia SUPERNOVAE FROM THE ESSENCE SURVEY
- 2016
-
Ingår i: Astrophysical Journal Supplement Series. - : American Astronomical Society. - 0067-0049 .- 1538-4365. ; 224:1
-
Tidskriftsartikel (refereegranskat)abstract
- The ESSENCE survey discovered 213 Type Ia supernovae at redshifts 0.1 < z < 0.81 between 2002 and 2008. We present their R- and I-band photometry, measured from images obtained using the MOSAIC II camera at the CTIO Blanco, along with rapid-response spectroscopy for each object. We use our spectroscopic follow-up observations to determine an accurate, quantitative classification, and precise redshift. Through an extensive calibration program we have improved the precision of the CTIO Blanco natural photometric system. We use several empirical metrics to measure our internal photometric consistency and our absolute calibration of the survey. We assess the effect of various potential sources of systematic bias on our measured fluxes, and estimate the dominant term in the systematic error budget from the photometric calibration on our absolute fluxes is similar to 1%.
|
|
| 4. |
- Foley, R. J., et al.
(författare)
-
Spectroscopy of High-Redshift Supernovae from the Essence Project : The First Four Years
- 2009
-
Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 137, s. 3731-3742
-
Tidskriftsartikel (refereegranskat)abstract
- We present the results of spectroscopic observations from the ESSENCE high-redshift supernova (SN) survey during its first four years of operation. This sample includes spectra of all SNe Ia whose light curves were presented by Miknaitis et al. and used in the cosmological analyses of Davis et al. and Wood-Vasey et al. The sample represents 273 hr of spectroscopic observations with 6.5-10 m class telescopes of objects detected and selected for spectroscopy by the ESSENCE team. We present 184 spectra of 156 objects. Combining this sample with that of Matheson et al., we have a total sample of 329 spectra of 274 objects. From this, we are able to spectroscopically classify 118 Type Ia SNe. As the survey has matured, the efficiency of classifying SNe Ia has remained constant while we have observed both higher-redshift SNe Ia and SNe Ia farther from maximum brightness. Examining the subsample of SNe Ia with host-galaxy redshifts shows that redshifts derived from only the SN Ia spectra are consistent with redshifts found from host-galaxy spectra. Moreover, the phases derived from only the SN Ia spectra are consistent with those derived from light-curve fits. By comparing our spectra to local templates, we find that the rate of objects similar to the overluminous SN 1991T and the underluminous SN 1991bg in our sample are consistent with that of the local sample. We do note, however, that we detect no object spectroscopically or photometrically similar to SN 1991bg. Although systematic effects could reduce the high-redshift rate we expect based on the low-redshift surveys, it is possible that SN 1991bg-like SNe Ia are less prevalent at high redshift.
|
|
| 5. |
- Greiner, J., et al.
(författare)
-
GRIPS - Gamma-Ray Imaging, Polarimetry and Spectroscopy
- 2012
-
Ingår i: Experimental astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 34:2, s. 551-582
-
Tidskriftsartikel (refereegranskat)abstract
- We propose to perform a continuously scanning all-sky survey from 200 keV to 80 MeV achieving a sensitivity which is better by a factor of 40 or more compared to the previous missions in this energy range (COMPTEL, INTEGRAL; see Fig. 1). These gamma-ray observations will be complemented by observations in the soft X-ray and (near-)infrared region with the corresponding telescopes placed on a separate satellite. The Gamma-Ray Imaging, Polarimetry and Spectroscopy ("GRIPS") mission with its three instruments Gamma-Ray Monitor (GRM), X-Ray Monitor (XRM) and InfraRed Telescope (IRT) addresses fundamental questions in ESA's Cosmic Vision plan. Among the major themes of the strategic plan, GRIPS has its focus on the evolving, violent Universe, exploring a unique energy window. We propose to investigate γ-ray bursts and blazars, the mechanisms behind supernova explosions, nucleosynthesis and spallation, the enigmatic origin of positrons in our Galaxy, and the nature of radiation processes and particle acceleration in extreme cosmic sources including pulsars and magnetars. The natural energy scale for these non-thermal processes is of the order of MeV. Although they can be partially and indirectly studied using other methods, only the proposed GRIPS measurements will provide direct access to their primary photons. GRIPS will be a driver for the study of transient sources in the era of neutrino and gravitational wave observatories such as IceCUBE and LISA, establishing a new type of diagnostics in relativistic and nuclear astrophysics. This will support extrapolations to investigate star formation, galaxy evolution, and black hole formation at high redshifts.
|
|
| 6. |
- Miknaitis, G., et al.
(författare)
-
The ESSENCE supernova survey : Survey optimization, observations, and supernova photometry
- 2007
-
Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 666:2, s. 674-693
-
Forskningsöversikt (refereegranskat)abstract
- We describe the implementation and optimization of the ESSENCE supernova survey, which we have undertaken to measure the dark energy equation-of-state parameter, w = P/(rho c(2)). We present a method for optimizing the survey exposure times and cadence to maximize our sensitivity to w for a given fixed amount of telescope time. For our survey on the CTIO 4 m telescope, measuring the luminosity distances and redshifts for supernovae at modest redshifts (z approximate to 0: 5 +/- 0: 2) is optimal for determining w. We describe the data analysis pipeline based on using reliable and robust image subtraction to find supernovae automatically and in nearly real time. Since making cosmological inferences with supernovae relies crucially on accurate measurement of their apparent brightnesses, we describe our efforts to establish a thorough calibration of the CTIO 4 m telescope's natural photometric system. In its first four years, ESSENCE has discovered and spectroscopically confirmed 102 Type Ia supernovae, at redshifts from 0.10 to 0.78, identified through an impartial, effective methodology for spectroscopic classification and redshift determination. We present the resulting light curves for all of the Type Ia supernovae found by ESSENCE and used in our measurement of w, presented in a companion paper by Wood-Vasey and coworkers.
|
|
| 7. |
- Wood-Vasey, W. M., et al.
(författare)
-
Observational constraints on the nature of dark energy : First cosmological results from the ESSENCE supernova survey
- 2007
-
Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 666:2, s. 694-715
-
Forskningsöversikt (refereegranskat)abstract
- We present constraints on the dark energy equation-of-state parameter, w = P/(rho c(2)), using 60 SNe Ia fromthe ESSENCE supernova survey. We derive a set of constraints on the nature of the dark energy assuming a flat universe. By including constraints on (Omega(M), w) from baryon acoustic oscillations, we obtain a value for a static equation-of-state parameter w = -1:05(-0.12)(+0: 13) (stat 1 sigma) +/- 0: 13 (sys) and Omega(M) = 0:274(-0.020)(+0:033) (stat 1 sigma) with a bestfit chi(2)/dof of 0.96. These results are consistent with those reported by the Supernova Legacy Survey from the first year of a similar program measuring supernova distances and redshifts. We evaluate sources of systematic error that afflict supernova observations and present Monte Carlo simulations that explore these effects. Currently, the largest systematic with the potential to affect our measurements is the treatment of extinction due to dust in the supernova host galaxies. Combining our set of ESSENCE SNe Ia with the first-results Supernova Legacy Survey SNe Ia, we obtain a joint constraint of w = -1:07(-0: 09)(+0:09) (stat 1 sigma) +/- 0: 13 ( sys), Omega(M) 0:267(-0:028)(+0:028) (stat 1 sigma) with a best-fit chi(2)/dof of 0.91. The current global SN Ia data alone rule out empty (Omega(M) = 0), matter-only Omega(M) = 0: 3, and Omega(M) = 1 universes at > 4.5 sigma. The current SN Ia data are fully consistent with a cosmological constant.
|
|
| 8. |
- Anderson, Beverley H., et al.
(författare)
-
Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus
- 2012
-
Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:3, s. 338-342
-
Tidskriftsartikel (refereegranskat)abstract
- Coats plus is a highly pleiotropic disorder particularly affecting the eye, brain, bone and gastrointestinal tract. Here, we show that Coats plus results from mutations in CTC1, encoding conserved telomere maintenance component 1, a member of the mammalian homolog of the yeast heterotrimeric CST telomeric capping complex. Consistent with the observation of shortened telomeres in an Arabidopsis CTC1 mutant and the phenotypic overlap of Coats plus with the telomeric maintenance disorders comprising dyskeratosis congenita, we observed shortened telomeres in three individuals with Coats plus and an increase in spontaneous gamma H2AX-positive cells in cell lines derived from two affected individuals. CTC1 is also a subunit of the alpha-accessory factor (AAF) complex, stimulating the activity of DNA polymerase-alpha primase, the only enzyme known to initiate DNA replication in eukaryotic cells. Thus, CTC1 may have a function in DNA metabolism that is necessary for but not specific to telomeric integrity.
|
|
| 9. |
- Davis, Tamara, et al.
(författare)
-
Scrutinizing Exotic Cosmological Models Using ESSENCE Supernova Data Combined with Other Cosmological Probes
- 2007
-
Ingår i: The Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 666:2, s. 716-725
-
Tidskriftsartikel (refereegranskat)abstract
- The first cosmological results from the ESSENCE supernova survey (Wood-Vasey and coworkers) are extended to a wider range of cosmological models including dynamical dark energy and nonstandard cosmological models. We fold in a greater number of external data sets such as the recent Higher-z release of high-redshift supernovae (Riess and coworkers), as well as several complementary cosmological probes. Model comparison statistics such as the Bayesian and Akaike information criteria are applied to gauge the worth of models. These statistics favor models that give a good fit with fewer parameters. Based on this analysis, the preferred cosmological model is the flat cosmological constant model, where the expansion history of the universe can be adequately described with only one free parameter describing the energy content of the universe. Among the more exotic models that provide good fits to the data, we note a preference for models whose best-fit parameters reduce them to the cosmological constant model.
|
|
| 10. |
- Larsson, Josefin, et al.
(författare)
-
The Matter Beyond the Ring : The Recent Evolution of SN 1987A Observed by the Hubble Space Telescope
- 2019
-
Ingår i: Astrophysical Journal. - : IOP PUBLISHING LTD. - 0004-637X .- 1538-4357. ; 886:2
-
Tidskriftsartikel (refereegranskat)abstract
- The nearby SN 1987A offers a spatially resolved view of the evolution of a young supernova (SN) remnant. Here we present recent Hubble Space Telescope imaging observations of SN 1987A, which we use to study the evolution of the ejecta, the circumstellar equatorial ring (ER), and the increasing emission from material outside the ER. We find that the inner ejecta have been brightening at a gradually slower rate and that the western side has been brighter than the eastern side since similar to 7000 days. This is expected given that the X-rays from the ER are most likely powering the ejecta emission. At the same time, the optical emission from the ER continues to fade linearly with time. The ER is expanding at 680 50 km s(-1), which reflects the typical velocity of transmitted shocks in the dense hot spots. A dozen spots and a rim of diffuse H alpha emission have appeared outside the ER since 9500 days. The new spots are more than an order of magnitude fainter than the spots in the ER and also fade faster. We show that the spots and diffuse emission outside the ER may be explained by fast ejecta interacting with high-latitude material that extends from the ER toward the outer rings. Further observations of this emission will make it possible to determine the detailed geometry of the high-latitude material and provide insight into the formation of the rings and the mass-loss history of the progenitor.
|
|
