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Sökning: WFRF:(Lekka M)

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  • Andronis, Christos, et al. (författare)
  • Molecular basis of mood and cognitive adverse events elucidated via a combination of pharmacovigilance data mining and functional enrichment analysis
  • 2020
  • Ingår i: Archives of Toxicology. - : Springer Nature. - 0340-5761 .- 1432-0738. ; 94:8, s. 2829-2845
  • Tidskriftsartikel (refereegranskat)abstract
    • Drug-induced Mood- and Cognition-related adverse events (MCAEs) are often only detected during the clinical trial phases of drug development, or even after marketing, thus posing a major safety concern and a challenge for both pharmaceutical companies and clinicians. To fill some gaps in the understanding and elucidate potential biological mechanisms of action frequently associated with MCAEs, we present a unique workflow linking observational population data with the available knowledge at molecular, cellular, and psychopharmacology levels. It is based on statistical analysis of pharmacovigilance reports and subsequent signaling pathway analyses, followed by evidence-based expert manual curation of the outcomes. Our analysis: (a) ranked pharmaceuticals with high occurrence of such adverse events (AEs), based on disproportionality analysis of the FDA Adverse Event Reporting System (FAERS) database, and (b) identified 120 associated genes and common pathway nodes possibly underlying MCAEs. Nearly two-thirds of the identified genes were related to immune modulation, which supports the critical involvement of immune cells and their responses in the regulation of the central nervous system function. This finding also means that pharmaceuticals with a negligible central nervous system exposure may induce MCAEs through dysregulation of the peripheral immune system. Knowledge gained through this workflow unravels putative hallmark biological targets and mediators of drug-induced mood and cognitive disorders that need to be further assessed and validated in experimental models. Thereafter, they can be used to substantially improve in silico/in vitro/in vivo tools for predicting these adversities at a preclinical stage.
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  • Budkowski, Andrzej, et al. (författare)
  • Polymer Blends Spin-Cast into Films with Complementary Elements for Electronics and Biotechnology
  • 2012
  • Ingår i: Journal of Applied Polymer Science. - Malden, MA : John Wiley & Sons. - 0021-8995 .- 1097-4628. ; 125:6, s. 4275-4284
  • Tidskriftsartikel (refereegranskat)abstract
    • Versatility of solution-processing strategy based on the simultaneous rather than additive deposition of different functional molecules is discussed. It is shown that spin-cast polymer blends result in films with domains that could form elements with complementary functions of (i) solar cells, (ii) electronic circuitries, and (iii) test plates for protein micro-arrays: Alternating layers, rich in electrondonating polyfluorene and electron-accepting fullerene derivative, result in optimized solar power conversion. Surface patterns, made by soft lithography, align conductive paths of conjugated poly(3-alkylthiophene) in dielectric polystyrene. Proteins, preserving their biologically activity, are adsorbed to hydrophobic domains of polystyrene in hydrophilic matrix of poly(ethylene oxide). The authors report the research progress on structure formation in three polymer blend families, resulting in films with complementary elements for electronics and biotechnology. Blend film structures are determined with secondary ion mass spectrometry, atomic force microscopy, and fluorescence microscopy. In addition, the authors present recent results on (i) structure formation in fullerene derivative/poly(3-alkylthiophene) blends intended for solar cells, (ii) 3-dimensional SIMS imaging of conductive paths of poly(3-alkylthiophene) in dielectric polystyrene, (iii) test lates for multiprotein micro-arrays fabricated with blend films of hydrophobic polystyrene and thermoresponsive poly (N-sopropylacrylamide).
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  • Budkowski, Andrzej, et al. (författare)
  • Structures in multi-component polymer films : their formation, observation and applications in electronics and biotechnology
  • 2009
  • Ingår i: Acta Physica Polonica. A. - Warsaw : Polish Academy of Sciences, Institute of Physics. - 0587-4246 .- 1898-794X. ; 115:2, s. 435-440
  • Tidskriftsartikel (refereegranskat)abstract
    • Several strategies to form multicomponent films of functional polymers, with micron, submicron and nanometer structures, intended for plastic electronics and biotechnology are presented. These approaches are based on film deposition from polymer solution onto a rotating substrate (spin-casting), a method implemented already on manufacturing lines. Film structures are determined with compositional (nanometer) depth profiling and (submicron) imaging modes of dynamic secondary ion mass spectrometry, near-field scanning optical microscopy (with submicron resolution) and scanning probe microscopy (revealing nanometer features). Self-organization of spin-cast polymer mixtures is discussed in detail, since it o®ers a one-step process to deposit and align simultaneously domains, rich in di®erent polymers, forming various device elements: (i) Surface segregation drives self-stratification of nanometer lamellae for solar cells and anisotropic conductors. (ii) Cohesion energy density controls morphological transition from lamellar (optimal for encapsulated transistors) to lateral structures (suggested for light emitting diodes with variable color). (iii) Selective adhesion to substrate microtemplates, patterned chemically, orders lateral structures for plastic circuitries. (iv) Submicron imprints of water droplets (breath figures) decorate selectively micron-sized domains, and can be used in devices with hierarchic structure. In addition, selective protein adsorption to regular polymer micropatterns, formed with soft lithography after spin-casting, suggests applications in protein chip technology. An approach to reduce lateral blend film structures to submicron scale is also presented, based on (annealed) films of multicomponent nanoparticles
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  • Diou, C, et al. (författare)
  • BigO: Big Data Against Childhood Obesity
  • 2018
  • Ingår i: HORMONE RESEARCH IN PAEDIATRICS. - 1663-2818. ; 90, s. 335-336
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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  • Resultat 1-10 av 16

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