| 1. |
- Delfin, Carl, et al.
(författare)
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A Federated Database for Obesity Research : An IMI-SOPHIA Study
- 2024
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Ingår i: Life. - 0024-3019. ; 14:2
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is considered by many as a lifestyle choice rather than a chronic progressive disease. The Innovative Medicines Initiative (IMI) SOPHIA (Stratification of Obesity Phenotypes to Optimize Future Obesity Therapy) project is part of a momentum shift aiming to provide better tools for the stratification of people with obesity according to disease risk and treatment response. One of the challenges to achieving these goals is that many clinical cohorts are siloed, limiting the potential of combined data for biomarker discovery. In SOPHIA, we have addressed this challenge by setting up a federated database building on open-source DataSHIELD technology. The database currently federates 16 cohorts that are accessible via a central gateway. The database is multi-modal, including research studies, clinical trials, and routine health data, and is accessed using the R statistical programming environment where statistical and machine learning analyses can be performed at a distance without any disclosure of patient-level data. We demonstrate the use of the database by providing a proof-of-concept analysis, performing a federated linear model of BMI and systolic blood pressure, pooling all data from 16 studies virtually without any analyst seeing individual patient-level data. This analysis provided similar point estimates compared to a meta-analysis of the 16 individual studies. Our approach provides a benchmark for reproducible, safe federated analyses across multiple study types provided by multiple stakeholders.
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| 2. |
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| 3. |
- Gustafsson, Mats, et al.
(författare)
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High-resolution digital transmission microscopy: a Fourier holography approach
- 2004
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Ingår i: Optics and Lasers in Engineering. - 0143-8166. ; 41:3, s. 553-563
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Tidskriftsartikel (refereegranskat)abstract
- A spherical reference field is used to construct a digital holographic system with a demonstrated resolution up to 228 line pairs per mm. The reference field originates from a GRIN lens placed 1 mm from the illuminated object. This allows the use of a standard sensor to record the hologram with the required numerical aperture. The image is determined by evaluation of the Rayleigh–Sommerfeld diffraction integral that relates the object field in the image plane to the object field in the sensor plane. Experimental results are given for two charge coupled device sensors and one complementary metal-oxide-semiconductor active pixel sensor.
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| 4. |
- Gustafsson, Mats, et al.
(författare)
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High resolution digital transmission microscopy : a Fourier holography approach
- 2002
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- A spherical reference field is used to construct a digital holography system with a demonstrated resolution down to 228 line pairs per mm. The reference field origin from a GRIN lens placed 1mm from the illuminated object. This allows the use of a standard sensor to record the hologram with the required numerical aperture. The image is determined by evaluation of the Rayleigh-Sommerfeld diffraction integral that relates the object field in the image plane to the object field in the sensor plane. Experimental results are given for two charge couple device sensors and one complementary metaloxide- semiconductor active pixel sensor.
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| 5. |
- Hedberg, Hugo, et al.
(författare)
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A complete MP3 decoder on a chip
- 2005
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Ingår i: Proceedings. 2005 IEEE International Conference on Microelectronic Systems Education. - 0769523749 ; , s. 103-104
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Konferensbidrag (refereegranskat)abstract
- The paper presents the results from a course project which focused on all levels in ASIC design flow by implementing a complete MP3 decoder. Two student teams developed a decoder targeting ASIC and FPGA, respectively. The ASIC decoder, fabricated in a 0.35 μm process from AMI Semiconductor, consumes 40 mW with a supply voltage of 2 V running at 12 MHz. The FPGA decoder has been implemented and verified on a Virtex-II platform
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| 6. |
- Hedberg, Hugo, et al.
(författare)
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Teaching digital HW-design by implementing a complete MP3 decoder
- 2003
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Ingår i: [Host publication title missing]. - 0769519733 ; , s. 31-32
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Konferensbidrag (refereegranskat)abstract
- This paper describes a project course that focuses on all the different stages in an ASIC design flow. The project starts at algorithm level, followed by architecture selection, netlist generation, down to physical layout, fabrication, and finally verification. The scope of the project, implementing a complete MP3 decoder in VHDL and sending it for fabrication, motivates the students to work hard towards a common goal
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| 7. |
- Lenart, Thomas, et al.
(författare)
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A 2048 complex point FFT processor using a novel data scaling approach
- 2003
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Ingår i: Proceedings - IEEE International Symposium on Circuits and Systems. - 2158-1525 .- 0271-4310. ; 4, s. 45-48
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Konferensbidrag (refereegranskat)abstract
- In this paper, a novel data scaling method for pipelined FFT processors is proposed. By using data scaling, the FFT processor can operate on a wide range of input signals without performance loss. Compared to existing block scaling methods, like implementations of Convergent Block Floating Point (CBFP), the memory requirements can be reduced while preserving the SNR. The FFT processor has been synthesized and sent for fabrication in a 0.35μm standard CMOS technology. In netlist simulations, the FFT processor is capable of calculating a 2048 complex point FFT or IFFT in 27μs with a maximum clock frequency of 76MHz.
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| 8. |
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| 9. |
- Lenart, Thomas, et al.
(författare)
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A hybrid interconnect network-on-chip and a transaction level modeling approach for reconfigurable computing
- 2008
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Ingår i: [Host publication title missing]. - 9780769531106 ; , s. 398-404
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Konferensbidrag (refereegranskat)abstract
- This paper presents a hybrid interconnect network consisting of a local network with dedicated wires and a global hierarchical network. A distributed memory approach enables the possibility to use generic memory banks as routing buffers, simplifies the implementation and reduces the area requirements of routers. A SystemC simulation environment (SCENIC) has been developed to simulate and instrument models, and to setup different topologies and scenarios. Modules are designed as transaction level models to improve design time and simulation speed.
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