| 1. |
- Ahrentorp, Fredrik, et al.
(författare)
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Effective particle magnetic moment of multi-core particles
- 2015
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Ingår i: Journal of Magnetism and Magnetic Materials. - : Elsevier BV. - 0304-8853 .- 1873-4766. ; 380, s. 221-226
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Tidskriftsartikel (refereegranskat)abstract
- In this study we investigate the magnetic behavior of magnetic multi-core particles and the differences in the magnetic properties of multi-core and single-core nanoparticles and correlate the results with the nanostructure of the different particles as determined from transmission electron microscopy (TEM). We also investigate how the effective particle magnetic moment is coupled to the individual moments of the single-domain nanocrystals by using different measurement techniques: DC magnetometry, AC susceptometry, dynamic light scattering and TEM. We have studied two magnetic multi-core particle systems BNF Starch from Micromod with a median particle diameter of 100 am and FeraSpin R from nanoPET with a median particle diameter of 70 nm - and one single-core particle system - SHP25 from Ocean NanoTech with a median particle core diameter of 25 nm. (C) 2014 Elsevier B.V. All rights reserved.
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| 2. |
- Albert, J., et al.
(författare)
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Risk of HIV transmission from patients on antiretroviral therapy: A position statement from the Public Health Agency of Sweden and the Swedish Reference Group for Antiviral Therapy
- 2014
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Ingår i: Scandinavian Journal of Infectious Diseases. - : Informa UK Limited. - 0036-5548 .- 1651-1980. ; 46:10, s. 673-677
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Tidskriftsartikel (refereegranskat)abstract
- The modern medical treatment of HIV with antiretroviral therapy (ART) has drastically reduced the morbidity and mortality in patients infected with this virus. ART has also been shown to reduce the transmission risk from individual patients as well as the spread of the infection at the population level. This position statement from the Public Health Agency of Sweden and the Swedish Reference Group for Antiviral Therapy is based on a workshop organized in the fall of 2012. It summarizes the latest research and knowledge on the risk of HIV transmission from patients on ART, with a focus on the risk of sexual transmission. The risk of transmission via shared injection equipment among intravenous drug users is also examined, as is the risk of mother-to-child transmission. Based on current knowledge, the risk of transmission through vaginal or anal intercourse involving the use of a condom has been judged to be minimal, provided that the person infected with HIV fulfils the criteria for effective ART. This probably also applies to unprotected intercourse, provided that no other sexually transmitted infections are present, although it is not currently possible to fully support this conclusion with direct scientific evidence. ART is judged to markedly reduce the risk of blood-borne transmission between people who share injection equipment. Finally, the risk of transmission from mother to child is very low, provided that ART is started well in advance of delivery.
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| 3. |
- Bergstrand, Karl-Johan, et al.
(författare)
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Nulägesanalys trädgård
- 2018
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Rapport (populärvet., debatt m.m.)abstract
- Rapporten Nulägesanalys - trädgård har genomförts inom ramen för projektgruppen Insatsstyrka trädgård. Syftet med inventeringen har varit att ge svar på vem som jobbar med trädgårdsvetenskap, vilka forskargrupper och med vilka forskningsämnen, samt identifiera framtida arbetsfält inom ämnet trädgårdsvetenskap och därmed ge uppslag för framtida utveckling av forskningsfält, utbildning och samverkan. I detta ingår att kartlägga trädgårdsvetenskaplig forskning, utbildning och samverkan vid SLU. Nulägesanalysen förväntas därmed ge en grund för fortsatt strategiskt arbete med att utveckla ämnet trädgårdsvetenskap (Horticultural Science) utifrån inventerade resurser och förutsättningar.
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| 4. |
- Bshara, Mussa, et al.
(författare)
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Fingerprinting Localization in Wireless Networks Based on Received-Signal-Strength Measurements : A Case Study on WiMAX Networks
- 2010
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Ingår i: IEEE Transactions on Vehicular Technology. - 0018-9545 .- 1939-9359. ; 59:1, s. 283-294
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Tidskriftsartikel (refereegranskat)abstract
- This paper considers the problem of fingerprinting localization in wireless networks based on received-signal-strength (RSS) observations. First, the performance of static localization using power maps (PMs) is improved with a new approach called the base-station-strict (BS-strict) methodology, which emphasizes the effect of BS identities in the classical fingerprinting. Second, dynamic motion models with and without road network information are used to further improve the accuracy via particle filters. The likelihood-calculation mechanism proposed for the particle filters is interpreted as a soft version (called BS-soft) of the BS-strict approach applied in the static case. The results of the proposed approaches are illustrated and compared with an example whose data were collected from a WiMAX network in a challenging urban area in the capitol city of Brussels, Belgium.
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| 5. |
- Bshara, Mussa, et al.
(författare)
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Robust Tracking in Cellular Networks Using HMM Filters and Cell-ID Measurements
- 2011
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Ingår i: IEEE Transactions on Vehicular Technology. - 0018-9545 .- 1939-9359. ; 60:3, s. 1016-1024
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Tidskriftsartikel (refereegranskat)abstract
- A localization algorithm based on cell identification (Cell-ID) information is proposed. Instead of building the localization decisions only on the serving base station, all the detected Cell-IDs (serving or nonserving) by the mobile station are utilized. The statistical modeling of user motion and the measurements are done via a hidden Markov model (HMM), and the localization decisions are made with maximum a posteriori estimation criterion using the posterior probabilities from an HMM filter. The results are observed and compared with standard alternatives on an example whose data were collected from a worldwide interoperability for microwave access network in a challenging urban area in the Brussels capitol city.
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| 6. |
- Bshara, Mussa, et al.
(författare)
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Tracking in WiMAX Networks Depending on SCORE Measurements
- 2009
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Ingår i: Proceedings of the 6th Workshop on Positioning, Navigation and Communication. - 9781424432936 - 9781424432929 ; , s. 229-234
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Konferensbidrag (refereegranskat)abstract
- Tracking in WiMax networks is gaining a lot of interest; especially after the mobile WiMax became one of the emerging technologies that promote low-cost deployment and evolving to provide IP-based services of high mobility including providing location-based services (LBS). Therefore, locating users in a cheap way thatdepend on the available network resources is becoming more and more interesting and an active topic for researchers. In this paper we consider the problem of tracking in WiMAX networks depending on SCOREobservations. The provided examples show that with efficient measurement data processing and with the help of already available data (street maps), plausible results can be achieved.
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| 7. |
- Byrgazov, Konstantin, et al.
(författare)
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Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide
- 2020
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Ingår i: THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY. - : SAGE PUBLICATIONS LTD. - 1758-8340 .- 1758-8359. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- Background: Low survival rates in metastatic high-grade osteosarcoma (HGOS) have remained stagnant for the last three decades. This study aims to investigate the role of aminopeptidase N (ANPEP) in HGOS progression and its targeting with a novel lipophilic peptidase-enhanced cytotoxic compound melphalan flufenamide (melflufen) in HGOS. Methods: Meta-analysis of publicly available gene expression datasets was performed to determine the impact ofANPEPgene expression on metastasis-free survival of HGOS patients. The efficacy of standard-of-care anti-neoplastic drugs and a lipophilic peptidase-enhanced cytotoxic conjugate melflufen was investigated in patient-derived HGOSex vivomodels and cell lines. The kinetics of apoptosis and necrosis induced by melflufen and doxorubicin were compared. Anti-neoplastic effects of melflufen were investigatedin vivo. Results: ElevatedANPEPexpression in diagnostic biopsies of HGOS patients was found to significantly reduce metastasis-free survival. In drug sensitivity assays, melflufen has shown an anti-proliferative effect in HGOSex vivosamples and cell lines, including those resistant to methotrexate, etoposide, doxorubicin, and PARP inhibitors. Further, HGOS cells treated with melflufen displayed a rapid induction of apoptosis and this sensitivity correlated with high expression ofANPEP. In combination treatments, melflufen demonstrated synergy with doxorubicin in killing HGOS cells. Finally, Melflufen displayed anti-tumor growth and anti-metastatic effectsin vivo. Conclusion: This study may pave the way for use of melflufen as an adjuvant to doxorubicin in improving the therapeutic efficacy for the treatment of metastatic HGOS.
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| 8. |
- Dela, Nicolas, et al.
(författare)
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A pilot evaluation of using large movement driving simulator experiments to study driver behaviour influence on active safety systems for commercial heavy vehicles
- 2009
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Ingår i: Proceedings of the 21st International Symposium on Dynamics of Vehicles on Roads and Tracks (IAVSD'09), Stockholm, Sweden, August 17-21, 2009. - Linköping : ViP - Virtual prototyping and assessment by simulation.
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The evaluation of active safety functions like Electronic Stability Control (ESC) is of increasing importance, driven by legislation, to commercial heavy vehicle producers and to society as a whole to predict the potential benefits of the systems. Direct testing in real traffic with normal drivers of those functions are most often infeasible due to cost, repeatability and safety. This paper presents an attempt to explore the possibility of using large scale moving based driving simulators to evaluate functions like ESC. This is conducted through a simulator experiment where the subject drivers have been provoked in driving scenarios to ESC interventions. The experiment indicates the possibility of using driving simulators for evaluation purposes. This implies that studies of the benefits can be performed with higher accuracy regarding repeatability and evaluation testing of active safety functions can be made more cost efficient and without jeopardizing safety of involved driver and other road-users.
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| 9. |
- Gottesman, Omer, et al.
(författare)
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Guidelines for reinforcement learning in healthcare
- 2019
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Ingår i: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 25:1, s. 16-18
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 10. |
- Justice, Anne E., et al.
(författare)
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Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
- 2019
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 51:3, s. 452-469
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Tidskriftsartikel (refereegranskat)abstract
- Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF >= 5%) and nine low-frequency or rare (MAF < 5%) coding novel variants. Pathway/gene set enrichment analyses identified lipid particle, adiponectin, abnormal white adipose tissue physiology and bone development and morphology as important contributors to fat distribution, while cross-trait associations highlight cardiometabolic traits. In functional follow-up analyses, specifically in Drosophila RNAi-knockdowns, we observed a significant increase in the total body triglyceride levels for two genes (DNAH10 and PLXND1). We implicate novel genes in fat distribution, stressing the importance of interrogating low-frequency and protein-coding variants.
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