| 1. |
- Aqueveque, Pedro, et al.
(författare)
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Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale
- 2015
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Ingår i: Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences. - : Walter de Gruyter GmbH. - 0939-5075. ; 70:3-4, s. 97-102
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Tidskriftsartikel (refereegranskat)abstract
- Liquid fermentations of the fungus Stereum rameale (No 2511) yielded extracts with antibacterial -activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration. Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 mu g/mL), Bacillus subtilis (10 mu g/mL) and Staphylococcus aureus (100 mu g/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2 against Escherichia coli was 200 mu g/mL. Compound 3 inhibited significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 mu g/mL, respectively.
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| 2. |
- Aqueveque, Pedro M., et al.
(författare)
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The impact of Andean Patagonian mycoflora in the search for new lead molecules
- 2017
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Ingår i: Annals of the New York Academy of Sciences. - : Wiley. - 0077-8923. ; 1401, s. 5-18
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Tidskriftsartikel (refereegranskat)abstract
- Secondary metabolites from fungi have become a major source of chemical innovation in programs searching for lead molecules with bioactivities, especially over the last 50 years. In this review, we discuss the fundamental considerations in the discovery of molecules for agricultural and medicinal uses. This group of organisms possesses a strong potential for scientific and industrial communities. Recently, the incorporation of new technologies for the artificial cultivation of fungi and the use of better equipment to isolate and identify active metabolites has allowed the discovery of leading molecules for the design of new and safer drugs and pesticides. The geographical region including the Patagonian Andes mountains harbors a wide diversity of fungi, many of them still unknown and so far associated with Chilean-Argentinian Andean endemic forests. There have been very few chemical studies of the fungi located in this region. However, those few studies have allowed the discovery of new molecules. We argue that the richness of fungal biodiversity in this region offers an interesting source for the discovery of bioactive molecules for the basic and applied sciences.
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