| 1. |
- Bai, Ru, et al.
(författare)
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Clinical characteristics and phylogenetic analysis of human enteric adenovirus type 41 (HAdV-F41) from children with gastroenteritis during SARS-CoV-2 pandemic
- 2024
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Ingår i: Infection, Genetics and Evolution. - : Elsevier. - 1567-1348 .- 1567-7257. ; 123
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Tidskriftsartikel (refereegranskat)abstract
- Human adenovirus type 41 (HAdV-F41) usually causes pediatrics gastroenteritis. However, it was reported to be associated with the outbreaks of severe acute hepatitis of unknown aetiology (SAHUA) in pediatrics during COVID-19 pandemic. In this study, we investigated the prevalence of enteric HAdV-F41 in 37,920 paediatric gastroenteritis cases from 2017 to 2022 in Guangzhou, China. All children presented were tested negative for SARS-CoV-2 during the “zero-COVID” period. The main clinical symptom of the children was diarrhea (96.5%). No fatalities nor liver abnormal symptoms was found. In 2021, one year since the pandemic of COVID-19, the prevalence of HAdV-F41 abruptly increased from 3.71% to 8.64% (P < 0.001). All of HAdV-F41 circulating worldwide were classified into eight different subtypes (G1-G8) based on the phylogenetic clustering permutation of the four capsid genes of HAdV-F41. G3 was the predominant subtype (56.2%; 77/137). CRV5 isolates from SAHUA cases belong to this subtype, in which N312D and H335D mutations in the short fiber knob were identified in both Guangzhou and CRV5 isolates, presumably changing the virus tropism by directly interacting with the heparin sulfate (HS) receptor. Additionally, a novel recombinant G6 subtype, which is unique and only circulating in China was first identified in this study. This is the first study highlighting the prevalence of HAdV-F41 in paediatric cases of gastroenteritis during COVID-19 pandemic in China. The clinical and viral evolution finding of HAdV-F41 provide insight into the clinical characteristics of children with HAdV-F41 infections as well as the uncertain role of HAdV-F41 in the cause of SAHUA.
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| 2. |
- Zhao, Yadong, 1985-, et al.
(författare)
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Fabrication of multidimensional bio-nanomaterials from nanocellulose oxalate
- 2023
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Ingår i: Cellulose. - : Springer Nature. - 0969-0239 .- 1572-882X. ; 30:4, s. 2147-2163
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Tidskriftsartikel (refereegranskat)abstract
- Nanocelluloses and cellulose nanomaterials derived from natural resources are a group of ideal platform materials for advanced applications. However, their synthesis through sustainable and facile processes to achieve the required properties are still challenging. Here, we prepare the nanocellulose oxalate (n-COX) from cotton with outstanding physicochemical properties by defining the optimal oxalic acid pretreatment conditions. Thus-obtained n-COX with unique 1D nanofiber shape as a platform material is further processed to various high-performance multidimensional bio-nanomaterials through several simple yet effective strategies. First, 2D n-COX films prepared through a casting-drying method show comparable or even better transparency and tensile strength than those made from other types of nanocelluloses. Second, 3D n-COX hydrogels/aerogels fabricated by a molding-crosslinking approach demonstrate good shape stability, well-preserved nanoporous networks, and qualified mechanical properties. Third, n-COX-derived bioinks display improved printability and fidelity, resulting in better size-preserving and shape-control of the 3D-bioprinted scaffolds. We expect this work could offer new insights on engineering natural cellulose and using n-COX as a platform material for further advanced fabrication, and thus, open up application potentials of this new nanocellulose.
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| 3. |
- Lu, Yu, et al.
(författare)
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Electroless deposition of high-uniformity nickel microbumps with ultrahigh resolution of 8 μm pitch for monolithic Micro-LED display
- 2024
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Ingår i: Materials Science in Semiconductor Processing. - 1369-8001. ; 175
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Tidskriftsartikel (refereegranskat)abstract
- Micro-light-emitting diode (Micro-LED) displays have attracted growing attention due to their unsurpassed properties that satisfy the requirements of reality/virtual reality (AR/VR) displays. A crucial procedure of monolithic integration technology in high-density microdisplays is the interconnection process, which is intimately associated with the quality of the display device. Microfluidic electroless interconnection (MELI), an innovative low-temperature and pressure-free chip-stacking approach that eliminates the warpage-induced issues and cracking damage of the chip caused by thermo-compression bonding (TCB), holds great promise as a technology for establishing interconnections between the CMOS driver and Micro-LED. However, the requirement for the consistency of the microbump arrays and the risk of creating bridges is significantly intensified with smaller gaps in stacked chips, which restricts the application range of MELI to high-density interconnects. This paper analyzes the feasibility of further lowering the stand-off height of stacked chips in ultrafine pitch interconnects by optimizing the bump preparation process. The plasma modification time and surfactant concentration during the bump preparation process have been investigated. The result indicated that microbump arrays with a uniformity of less than 3% could be successfully manufactured by employing a 7-min plasma treatment and incorporating optimal surfactants, which catalyzes the implementation of the subsequent vertical interconnection process and eventually enhances yields of Micro-LEDs.
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| 4. |
- Lu, Yu, et al.
(författare)
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Electroless deposition of nickel microbumps for fine-pith flip-chip bonding
- 2024
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Ingår i: Journal of Physics: Conference Series. - 1742-6588 .- 1742-6596. ; 2783:1
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Konferensbidrag (refereegranskat)abstract
- The reliability of micro-light-emitting diode (Micro-LED) is closely associated with the uniformity of microbumps arrays. With continual decreases in pixel pitch in recent years, it is a challenge to guarantee the uniformity of bump arrays. To satisfy current requirements for ultra-high-density interconnections, this study proposes an electroless plating method for fabricating highly uniform nickel microbumps. This technique differs from electroplating, in which the morphology and consistency of microbumps can be easily controlled. Furthermore, it is a high-selectivity and cost-effective method of microbumps fabrication that eliminates solder wastage and avoids metal lift-off in traditional evaporation. To minimize the non-uniformity of the bumps, we aim to optimize the oxygen plasma treatment parameters and deposition intervals to eliminate the issues of skip plating, hydrogen bubble entrapment, and nodules. Under the combined effect of plasma treatment and intermittent deposition method, microbump arrays with less than 5% uniformity were successfully prepared, achieving the demands of high-density bonding. In addition, the preparation process is highly reproducible, extending the application range of this technique.
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| 5. |
- Neves, Antonio Alvaro Ranha, et al.
(författare)
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Beam displacement due to thermal blooming in optical tweezers
- 2019
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Ingår i: Optical Manipulation and Its Applications - Proceedings Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA, BRAIN, NTM, OMA, OMP).
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Konferensbidrag (refereegranskat)abstract
- Water near an optically trapped particle absorbs part of the laser energy resulting in changes for the refractive index and density. Particle position and optical potential description are affected by this photothermal effect.
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