| 1. |
- Chen, Yufeng, et al.
(författare)
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Oral fungal profiling and risk of nasopharyngeal carcinoma : a population-based case-control study
- 2023
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Ingår i: EBioMedicine. - 2352-3964. ; 96
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Dysbiosis of the oral mycobiome has been linked to some diseases, including cancers. However, the role of oral fungal communities in nasopharyngeal carcinoma (NPC) carcinogenesis has not previously been investigated.METHODS: We characterized the oral salivary fungal mycobiome in 476 untreated incident NPC patients and 537 population-based controls using fungal internal transcribed spacer (ITS)-2 sequencing. The relationship between oral fungal mycobiome and the risk of NPC was assessed through bioinformatic and biostatistical analyses.FINDINGS: We found that lower fungal alpha diversity was associated with an increased odds of NPC [lower vs. higher: observed features (adjusted odds ratio [OR] = 5.81, 95% confidence interval [CI] = 3.60-9.38); Simpson diversity (1.53, 1.03-2.29); Shannon diversity (2.03, 1.35-3.04)]. We also observed a significant difference in global fungal community patterns between cases and controls based on Bray-Curtis dissimilarity (P < 0.001). Carriage of oral fungal species, specifically, Saccharomyces cerevisiae, Candida tropicalis, Lodderomyces elongisporus, Candida albicans, and Fusarium poae, was associated with significantly higher odds of NPC, with ORs ranging from 1.56 to 4.66. Individuals with both low fungal and low bacterial alpha diversity had a profoundly elevated risk of NPC.INTERPRETATION: Our results suggest that dysbiosis in the oral mycobiome, characterized by a loss of fungal community diversity and overgrowth of several fungal organisms, is associated with a substantially increased risk of NPC.FUNDING: This work was funded by the US National Institutes of Health, the Swedish Research Council, the High-level Talents Research Start-up Project of Fujian Medical University, and the China Scholarship Council.
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| 2. |
- Li, Wanxin, et al.
(författare)
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Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis
- 2023
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Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association For Cancer Research (AACR). - 1055-9965 .- 1538-7755. ; 32:6, s. 809-817
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Tidskriftsartikel (refereegranskat)abstract
- Background: Human gut microbiome has complex relation-ships with the host, contributing to metabolism, immunity, and carcinogenesis.Methods: Summary-level data for gut microbiota and metabo-lites were obtained from MiBioGen, FINRISK and human meta-bolome consortia. Summary-level data for colorectal cancer were derived from a genome-wide association study meta-analysis. In forward Mendelian randomization (MR), we employed genetic instrumental variables (IV) for 24 gut microbiota taxa and six bacterial metabolites to examine their causal relationship with colorectal cancer. We also used a lenient threshold for nine apriori gut microbiota taxa as secondary analyses. In reverse MR, we explored association between genetic liability to colorectal neoplasia and abundance of microbiota studied above using 95, 19, and 7 IVs for colorectal cancer, adenoma, and polyps, respectively.Results: Forward MR did not find evidence indicating causal relationship between any of the gut microbiota taxa or six bacterial metabolites tested and colorectal cancer risk. However, reverse MR supported genetic liability to colorectal adenomas was causally related with increased abundance of two taxa: Gammaproteobacteria (b = 0.027, which represents a 0.027 increase in log-transformed relative abundance values of Gam-maproteobacteria for per one-unit increase in log OR of adenoma risk; P = 7.06x10-8), Enterobacteriaceae (b = 0.023, P = 1.29x10-5).Conclusions: We find genetic liability to colorectal neoplasia may be associated with abundance of certain microbiota taxa. It is more likely that subset of colorectal cancer genetic liability variants changes gut biology by influencing both gut microbiota and colo-rectal cancer risk.Impact: This study highlights the need of future complemen-tary studies to explore causal mechanisms linking both host genetic variation with gut microbiome and colorectal cancer susceptibility.
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| 3. |
- Carlsson, Fredrik, 1968, et al.
(författare)
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Subjective well-being among preadolescents and their parents - Evidence of intergenerational transmission of well-being from urban China
- 2014
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Ingår i: Journal of Socio-Economics. - : Elsevier BV. - 1053-5357. ; 48, s. 11-18
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Tidskriftsartikel (refereegranskat)abstract
- This paper examines whether intergenerational transmission of happiness exists in China between preadolescents and their parents, and what factors are correlated with subjective well-being among them. We find that parents' and their children's levels of subjective well-being are indeed significantly correlated, yet the factors that affect their well-being differ. Higher income, being a female, higher education, good health, and not being divorced result in higher well-being among the parents. Preadolescents' well-being is instead determined by different kinds of interactions with peers and parents, where being bullied or not is one of the most important factors. © 2013 Elsevier Inc.
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| 4. |
- Carlsson, Fredrik, 1968, et al.
(författare)
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Subjective well-being among preadolescents - Evidence from urban China
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- We examine what factors are correlated with subjective well-being among Chinese preadolescents. In particular, we investigate whether preadolescents’ subjective well-being is correlated with their parents’ subjective well-being. Interestingly, we find that the factors that affect parents’ subjective well-being do not influence their preadolescents’ subjective well-being, nor is there a significant correlation between the preadolescents’ subjective well-being and the well-being of their parents. Instead, we find that factors such as number of close friends, not being bullied, and spending time and conversing with parents are positively correlated with preadolescents´ subjective well-being. Another interesting finding is that preadolescents´ well-being does not seem to be correlated with their school performance.
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