| 1. |
- Li, Guofa, et al.
(författare)
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Driver Behavior in Intelligent Transportation Systems
- 2022
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Ingår i: IEEE Intelligent Transportation Systems Magazine. - 1939-1390 .- 1941-1197. ; 14:3, s. 7-9
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Drivers are the center of road/air/sea transportation systems, and they can be either human beings or artificial beings. Inconsistency between human driver behavior and artificial driver behavior will lead to accidents and congestion in intelligent transportation systems (ITSs) [1] , [2] . To make future ITSs trustworthy for traffic safety and acceptable for travel efficiency, developing industrial ITS applications based on drivers’ reliable behavioral and cognitive intelligence is essential [3] . However, there are many challenges to be addressed, including real-time behavior prediction, reliable decision making, safe interaction among human and artificial drivers, and so on.
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| 2. |
- Wen, Wanqing, et al.
(författare)
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Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference
- 2016
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in Europeanancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to 17,110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3, CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI. Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci. Our study provides additional insight on genetic contribution to abdominal obesity.
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| 3. |
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| 4. |
- Li, Jiayang, et al.
(författare)
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Electrochemical Zintl Cluster Bi22− induced chemically bonded bismuth / graphene oxide composite for sodium-ion batteries
- 2022
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Ingår i: Electrochimica Acta. - : Elsevier BV. - 0013-4686 .- 1873-3859. ; 413
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Tidskriftsartikel (refereegranskat)abstract
- Bismuth, a promising attribute for sodium-ion batteries, which have been attracting significant attention owing to their advantages of high volumetric capacity and suitable operating potential. However, most traditional Bi-based materials are suffered from pulverization and fracture of the electrodes caused by dramatic volume variation, consequently diminishing the cycle stability. Herein, in this work, bismuth embedded within graphene oxide matrices have been obtained by utilizing a novel and efficient electrochemical method. Through the strong reducing properties of Zintl clusters Bi22−, GO is partially reduced to generate reduced graphene oxide with better electrical conductivity. Simultaneously, Bi is strongly loaded on the GO through Bi-O-C bonding, which can form Bi2O22+ with excellent ionic conductivity. Moreover, the volume expansion of Bi during sodiation can be effectively buffered in the GO matrices. As a result, this Bi/GO composite exhibits excellent electrochemical performances in sodium-ion batteries (SIBs), including a high specific capacity of 258 mAh g−1 at 10 A g−1 and an excellent cycle stability with high retained capacity of 315 mAh g−1 after 500 cycles at 2 A g−1. This work paves the way to prepare designated promising electrode materials for high-performance SIBs, and thoroughly understands mechanism of electrochemical methods for preparing materials.
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| 5. |
- Lin, Qing-Fang, et al.
(författare)
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A stable aluminosilicate zeolite with intersecting three-dimensional extra-large pores
- 2021
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 374:6575, s. 1605-1608
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Tidskriftsartikel (refereegranskat)abstract
- Zeolites are crystalline porous materials with important industrial applications, including uses in catalytic and adsorption-separation processes. Access into and out of their inner confined space, where adsorption and reactions occur, is limited by their pore apertures. Stable multidimensional zeolites with larger pores able to process larger molecules are in demand in the fine chemical industry and for the oil processing on which the world still relies for fuels. Currently known extra-large-pore zeolites display poor stability and/or lack pore multidimensionality, limiting their usefulness. We report ZEO-1, a robust, fully connected aluminosilicate zeolite with mutually intersecting three-dimensional extra-large plus three-dimensional large pores. ZEO-1 is stable up to 1000 degrees C, has an extraordinary specific surface area (1000 square meters per gram), and shows potential as a catalytic cracking catalyst.
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| 6. |
- Pecori, Riccardo, et al.
(författare)
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ADAR1-mediated RNA editing promotes B cell lymphomagenesis
- 2023
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Ingår i: iScience. - : Cell Press. - 2589-0042. ; 26:6
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Tidskriftsartikel (refereegranskat)abstract
- Diffuse large B cell lymphoma (DLBCL) is one of the most common types of aggressive lymphoid malignancies. Here, we explore the contribution of RNA editing to DLBCL pathogenesis. We observed that DNA mutations and RNA editing events are often mutually exclusive, suggesting that tumors can modulate pathway outcomes by altering sequences at either the genomic or the transcriptomic level. RNA editing targets transcripts within known disease-driving pathways such as apoptosis, p53 and NF-kappa B signaling, as well as the RIG-I-like pathway. In this context, we show that ADAR1-mediated editing within MAVS transcript positively correlates with MAVS protein expression levels, associating with increased interferon/NF-kappa B signaling and T cell exhaustion. Finally, using targeted RNA base editing tools to restore editing within MAVS 3 ' UTR in ADAR1-deficient cells, we demonstrate that editing is likely to be causal to an increase in downstream signaling in the absence of activation by canonical nucleic acid receptor sensing.
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| 7. |
- Shang, Xiaobo, et al.
(författare)
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Emerging materials for circularly polarized light detection
- 2022
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Ingår i: Journal of Materials Chemistry C. - : ROYAL SOC CHEMISTRY. - 2050-7526 .- 2050-7534. ; 10:7, s. 2400-2410
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Forskningsöversikt (refereegranskat)abstract
- Detecting circularly polarized light (CPL) signals is the key technique in many advanced sensing technologies. Over recent decades, many efforts have been devoted to both the material design and the device engineering of CPL photodetectors. CPL detectors with different sensing wavelengths have distinct applications in bio-imaging, drug discovery, and information encryption. In this review, we first introduce the working principle of state-of-the-art CPL photodetectors followed by a general material design strategy. We then systematically summarize the recent progress on the chiral materials developed for CPL detection, including inorganic metamaterials, organics, hybridized materials, etc. We compare and analyse the photocurrent dissymmetry factors of these systems and provide perspectives on strategies to improve the dissymmetry factors and extend the detection wavelength. We believe that the information we include in this review would attract broader interest from researchers working on different aspects of organic and hybridized semiconductor materials and devices.
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| 8. |
- Shi, Peng, et al.
(författare)
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Age- and gender-specific trends in respiratory outpatient visits and diagnoses at a tertiary pediatric hospital in China : a 10-year retrospective study
- 2020
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Ingår i: BMC Pediatrics. - : BioMed Central. - 1471-2431. ; 20:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Respiratory infections are one of three leading causes of childhood mortality, and worldwide increase and recent plateau in childhood asthma has been reported. However, data on trends of respiratory diseases over long period of time is limited. This study aimed to determine the trends of respiratory disease outpatient visits (ROVs) and diagnoses (RODs) in one of the largest children's teaching hospitals in China between 2009 and 2018.METHODS: A retrospective study based on routine administrative data was designed and implemented according to the RECORD statement. Demographic details and diagnoses of the outpatients < 18 years visiting the respiratory department of the hospital were extracted from the Hospital Information System. Age- and gender-specific trends were illustrated by calculating average annual growth rate (AAGR) for ROVs and comparing change of proportion for different RODs over time.RESULTS: There were 698,054 ROVs from 285,574 children (40.4% female). AAGR of ROVs was 15.2%. Children aged 4 to < 7 years had a faster increase than other age groups. Bronchitis (27.6%), pneumonia (18.5%), pneumonia affecting other systems (18.4%), asthma and status asthmaticus (10.7%), and vasomotor and allergic rhinitis (9.2%) accounted for 84.4% of all RODs. The proportion of bronchitis decreased across years, with the concomitant increasing trend in the proportion of pneumonia. Age-specific trend in diagnoses showed greater proportion of asthma in all visits for the children aged 7 to < 18 years than younger children. Gender-specific trend in diagnoses showed the proportion of asthma was greater for males but the AAGR was greater for females.CONCLUSION: The persistent upward trend in ROVs was observed among children at different ages and a gender difference was also seen. In contrast to what has been reported, burden of asthma and allergies diseases continues to increase locally.
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| 9. |
- Wang, Juan, et al.
(författare)
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GWAS Discovery Of Candidate Genes for Yield-Related Traits in Peanut and Support from Earlier QTL Mapping Studies
- 2019
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Ingår i: Genes. - : MDPI AG. - 2073-4425. ; 10:10
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Tidskriftsartikel (refereegranskat)abstract
- Peanut (Arachishypogaea L.) is one of the most important oil crops worldwide, and its yet increasing market demand may be met by genetic improvement of yield related traits, which may be facilitated by a good understanding of the underlying genetic base of these traits. Here, we have carried out a genome-wide association study (GWAS) with the aim to identify genomic regions and the candidate genes within these regions that may be involved in determining the phenotypic variation at seven yield-related traits in peanut. For the GWAS analyses, 195 peanut accessions were phenotyped and/or genotyped; the latter was done using a genotyping-by-sequencing approach, which produced a total of 13,435 high-quality single nucleotide polymorphisms (SNPs). Analyses of these SNPs show that the analyzed peanut accessions can be approximately grouped into two big groups that, to some extent, agree with the botanical classification of peanut at the subspecies level. By taking this genetic structure as well as the relationships between the analyzed accessions into consideration, our GWAS analyses have identified 93 non-overlapping peak SNPs that are significantly associated with four of the studied traits. Gene annotation of the genome regions surrounding these peak SNPs have found a total of 311 unique candidate genes. Among the 93 yield-related-trait-associated SNP peaks, 12 are found to be co-localized with the quantitative trait loci (QTLs) that were identified by earlier related QTL mapping studies, and these 12 SNP peaks are only related to three traits and are almost all located on chromosomes Arahy.05 and Arahy.16. Gene annotation of these 12 co-localized SNP peaks have found 36 candidates genes, and a close examination of these candidate genes found one very interesting gene (arahy.RI9HIF), the rice homolog of which produces a protein that has been shown to improve rice yield when over-expressed. Further tests of the arahy.RI9HIF gene, as well as other candidate genes especially those within the more confident co-localized genomic regions, may hold the potential for significantly improving peanut yield.
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| 10. |
- Wang, Juan, et al.
(författare)
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The genetic base for peanut height-related traits revealed by a meta-analysis
- 2021
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Ingår i: Plants. - : MDPI AG. - 2223-7747. ; 10:6
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Tidskriftsartikel (refereegranskat)abstract
- Peanut (Arachis hypogaea L.) is an important oilseed crop worldwide, and peanut height has been shown to be closely related to yield, therefore a better understanding of the genetic base of plant height-related traits may allow us to have better control of crop yield. Plant height-related traits are quantitative traits that are genetically controlled by many genes, and distinct quantitive trait loci (QTLs) may be identified for different peanut accessions/genotypes. In the present study, in order to gain a more complete picture of the genetic base for peanut height-related traits, we first make use of the high quality NGS sequence data for 159 peanut accessions that are available within our research groups, to carry out a GWAS study for searching plant height-related regions. We then perform a literature survey and collect QTLs for two plant height-related traits (Ph: peanut main stem height, and Fbl: the first branch length) from earlier related QTL/GWAS studies in peanut. In total, we find 74 and 21 genomic regions that are, associated with traits Ph and Fbl, respectively. Annotation of these regions found a total of 692 and 229 genes for, respectively, Ph and Fbl, and among those genes, 158 genes are shared. KEGG and GO enrichment analyses of those candidate genes reveal that Ph-and Fbl-associated genes are both enriched in the biosynthesis of secondary metabolites, some basic processes, pathways, or complexes that are supposed to be crucial for plant development and growth.
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