| 1. |
- Chen, Chengshui, et al.
(författare)
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Preventive and Therapeutic Effects of Phosphoinositide 3-Kinase Inhibitors on Acute Lung Injury
- 2011
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Ingår i: Chest. - : Elsevier BV. - 1931-3543 .- 0012-3692. ; 140:2, s. 391-400
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Tidskriftsartikel (refereegranskat)abstract
- Background: Phosphoinositide 3-kinases (PI3Ks) are involved in a number of biologic responses. Recent preclinical studies demonstrated that the PI3K-dominant signal pathway could play an important role in the development of acute lung injury, although the mechanism remains unclear. Methods: CD-1 mice were administered different PI3K inhibitors either intranasally or intragastrically once a day for 3 days before intratracheal instillation of lipopolysaccharide at 4 h and 24 h. Effects of SHBM1009 on lipopolysaccharide-induced capillary permeability, leukocyte distribution and activation, and epithelial cell function were measured. Therapeutic effects of SHBM1009 on pancreatic elastase-induced lung injury were evaluated in rats. Results: The data demonstrated that the local delivery of PI3K inhibitors played more effective roles in the prevention of endotoxin-induced lung injury than the systemic delivery. The preventive effects of PI3K inhibitors varied most likely because of chemical properties, targeting sites, and pharmacokinetics. The local PI3K inhibitors prevented both endotoxin- and elastase-induced lung injury in mice and rats, possibly through directly inhibiting or inactivating the function of airway epithelial cells, which could not produce chemoattractant factors to activate neutrophils and macrophages. Conclusions: PI3K may be a therapeutic target for lung injury, and local delivery of PI3K inhibitors may be one of the optimal approaches for the therapy. CHEST 2011; 140(2):391-400
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| 2. |
- Cheng, X. P., et al.
(författare)
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The Most Compact Bright Radio-loud AGNs. II. VLBA Observations of 10 Sources at 43 and 86 GHz
- 2018
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Ingår i: Astrophysical Journal, Supplement Series. - : American Astronomical Society. - 1538-4365 .- 0067-0049. ; 234:1
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Tidskriftsartikel (refereegranskat)abstract
- Radio-loud active galactic nuclei (AGNs), hosting powerful relativistic jet outflows, provide an excellent laboratory for studying jet physics. Very long baseline interferometry (VLBI) enables high-resolution imaging on milli-arcsecond (mas) and sub-mas scales, making it a powerful tool to explore the inner jet structure, shedding light on the formation, acceleration, and collimation of AGN jets. In this paper, we present Very Long Baseline Array observations of 10 radio-loud AGNs at 43 and 86 GHz that were selected from the Planck catalog of compact sources and are among the brightest in published VLBI images at and below 15 GHz. The image noise levels in our observations are typically 0.3 and 1.5 mJy beam -1 at 43 and 86 GHz, respectively. Compared with the VLBI data observed at lower frequencies from the literature, our observations with higher resolutions (with the highest resolution being up to 0.07 mas at 86 GHz and 0.18 mas at 43 GHz) and at higher frequencies detected new jet components at sub-parsec scales, offering valuable data for studies of the physical properties of the innermost jets. These include the compactness factor of the radio structure (the ratio of core flux density to total flux density), and core brightness temperature (T b ). In all these sources, the compact core accounts for a significant fraction ( > 60%) of the total flux density. Their correlated flux density at the longest baselines is higher than 0.16 Jy. The compactness of these sources make them good phase calibrators of millimeter-wavelength ground-based and space VLBI.
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| 3. |
- Guo, Lijie, et al.
(författare)
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Industrial practice on optimizing tailings composition combined with ore concentration processes
- 2017
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Ingår i: 12th International Conference on Mining with Backfill 2017, Minefill 2017. - Englewood, CO : Society for Mining, Metallurgy and Exploration. - 9781510835818 ; , s. 69-79
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Konferensbidrag (refereegranskat)abstract
- Cemented paste backfill (CPB) is increasingly applied in underground mines world-wide and has a broad prospect considering its benefits in environmental protection and ground control. During the paste production, a well-graded aggregate is critical for the achievement of CPB. Mine tailings from the outcome of ore-dressing plant are commonly used as the fill aggregate. However, it is difficult to obtain an ideal particle size distribution for the mine tailings which are roughly mixed with final residuum in ore concentration processes. In this study, a novel industrial method is proposed to select fill aggregates from different parts of ore-dressing processes. With combined design of concentration plant and backfill plant, the tailings with desired particle sizes and proportions during the mineral processing are chosen to produce CPB without disturbing the regular ore concentration. The problem of passively accepting final tailings from ore-dressing plant has been improved
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| 4. |
- Miller, Victoria, et al.
(författare)
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Associations of the glycaemic index and the glycaemic load with risk of type 2 diabetes in 127594 people from 20 countries (PURE): a prospective cohort study
- 2024
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Ingår i: The Lancet Diabetes and Endocrinology. - 2213-8587 .- 2213-8595. ; 12, s. 330-338
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Tidskriftsartikel (refereegranskat)abstract
- Background: The association between the glycaemic index and the glycaemic load with type 2 diabetes incidence is controversial. We aimed to evaluate this association in an international cohort with diverse glycaemic index and glycaemic load diets. Methods: The PURE study is a prospective cohort study of 127 594 adults aged 35–70 years from 20 high-income, middle-income, and low-income countries. Diet was assessed at baseline using country-specific validated food frequency questionnaires. The glycaemic index and the glycaemic load were estimated on the basis of the intake of seven categories of carbohydrate-containing foods. Participants were categorised into quintiles of glycaemic index and glycaemic load. The primary outcome was incident type 2 diabetes. Multivariable Cox Frailty models with random intercepts for study centre were used to calculate hazard ratios (HRs). Findings: During a median follow-up of 11·8 years (IQR 9·0–13·0), 7326 (5·7%) incident cases of type 2 diabetes occurred. In multivariable adjusted analyses, a diet with a higher glycaemic index was significantly associated with a higher risk of diabetes (quintile 5 vs quintile 1; HR 1·15 [95% CI 1·03–1·29]). Participants in the highest quintile of the glycaemic load had a higher risk of incident type 2 diabetes compared with those in the lowest quintile (HR 1·21, 95% CI 1·06–1·37). The glycaemic index was more strongly associated with diabetes among individuals with a higher BMI (quintile 5 vs quintile 1; HR 1·23 [95% CI 1·08–1·41]) than those with a lower BMI (quintile 5 vs quintile 1; 1·10 [0·87–1·39]; p interaction=0·030). Interpretation: Diets with a high glycaemic index and a high glycaemic load were associated with a higher risk of incident type 2 diabetes in a multinational cohort spanning five continents. Our findings suggest that consuming low glycaemic index and low glycaemic load diets might prevent the development of type 2 diabetes. Funding: Full funding sources are listed at the end of the Article.
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| 5. |
- Yan, Guanzhou, et al.
(författare)
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The record of early Silurian climate changes from South China and Baltica based on integrated conodont biostratigraphy and isotope chemostratigraphy
- 2022
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Ingår i: Palaeogeography, Palaeoclimatology, Palaeoecology. - : Elsevier BV. - 0031-0182. ; 606
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Tidskriftsartikel (refereegranskat)abstract
- New conodont and stable isotope data are presented from the classical Baizitian section in the Yanbian County of Sichuan Province, South China. The Telychian to Sheinwoodian strata were sampled and studied for carbon isotope stratigraphy and conodont biostratigraphy. The paired δ13Ccarb and δ13Corg data reveal a pronounced positive excursion, the Manitowoc carbon isotope excursion (Manitowoc CIE, ‘Manitowoc Excursion’) spanning the upper Pterospathodus eopennatus Zone and the lower Pterospathodus amorphognathoides amorphognathoides Superzone, with an increase of ca. 2‰ in δ13Ccarb and ca. 5‰ in δ13Corg. Well-bracketed by conodont biostratigraphy, the Manitowoc CIE is an essential tie-point for correlation between the Baizitian succession and the Telychian strata of Baltica and Laurentia. Our new δ13Ccarb and δ13Corg data imply that the carbon isotope excursion previously recognized as the ‘Ireviken Excursion’ (Early Sheinwoodian Carbon Isotope Excursion) at Baizitian should be revised as being the Manitowoc CIE. The Δ13C data presented in this study further suggest a slight concurrent drop of atmospheric CO2, and thus add evidence for a perturbation of the global carbon cycle during the middle Telychian. Based on the combined information from the conodont apatite oxygen isotope records from Estonia and the significant stratigraphic gaps recognized at the Baizitian section, we propose that the latter stratigraphic gaps should correlate with the Telychian Valgu and the early Sheinwoodian glaciation.
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