| 1. |
- Weinstein, John N., et al.
(författare)
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The cancer genome atlas pan-cancer analysis project
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:10, s. 1113-1120
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Tidskriftsartikel (refereegranskat)abstract
- The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile. © 2013 Nature America, Inc. All rights reserved.
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| 2. |
- Franco, Claudio Areias, et al.
(författare)
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Serum response factor is required for sprouting angiogenesis and vascular integrity
- 2008
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Ingår i: Developmental Cell. - : Elsevier BV. - 1534-5807. ; 15:3, s. 448-461
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Tidskriftsartikel (refereegranskat)abstract
- Serum response factor (SRF) is a transcription factor that controls the expression of cytoskeletal proteins and immediate early genes in different cell types. Here, we found that SRF expression is restricted to endothelial cells (ECs) of small vessels such as capillaries in the mouse embryo. EC-specific Srf deletion led to aneurysms and hemorrhages from 11.5 days of mouse development (E11.5) and lethality at E14.5. Mutant embryos presented a reduced capillary density and defects in EC migration, with fewer numbers of filopodia in tip cells and ECs showing defects in actin polymerization and intercellular junctions. We show that SRF is essential for the expression of VE-cadherin and beta-actin in ECs both in vivo and in vitro. Moreover, knockdown of SRF in ECs impaired VEGF- and FGF-induced in vitro angiogenesis. Taken together, our results demonstrate that SRF plays an important role in sprouting angiogenesis and small vessel integrity in the mouse embryo.
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| 3. |
- Domellöf, Fatima Pedrosa, et al.
(författare)
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Desmin in extraocular muscles
- 2015
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Ingår i: Investigative Ophthalmology and Visual Science. - : ASSOC RESEARCH VISION OPHTHALMOLOGY. - 0146-0404 .- 1552-5783. ; 56:7
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Fan, Xu, et al.
(författare)
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Effects of different supplementary cementitious materials on the performance and environment of eco-friendly mortar prepared from waste incineration bottom ash
- 2022
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Ingår i: Construction and Building Materials. - : Elsevier BV. - 0950-0618. ; 356
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Tidskriftsartikel (refereegranskat)abstract
- Municipal solid waste incineration bottom ash (MSWIBA) is a by-product produced by municipal waste incineration treatment. In this study, MSWIBA particle size distribution, chemical composition and particle shape were investigated and confirmed its value for reuse in the construction field and its good research potential. MSWIBA was used as fine aggregates, while coal fly ash (FA) and ground granulated blast furnace slag (GGBFS) were used as auxiliary cementitious materials to replace part of cement to manufacture the eco-friendly mortar (EFM). The effect of FA/GGBFS on the mechanical and microscopic properties of EFM with different material ratios was mainly investigated. And the analysis of the environmental friendliness and economy of this EFM was made. The results show that the combination of FA and GGBFS at the same time reduces the early mechanical properties of the mortar. However, the strength developed rapidly after 7 days, with an increase of more than 6 times the rate before 7 days. Compared with GGBFS, FA is more helpful in improving the mechanical properties of the EFM. After 28 days of full hydration, the hydration products within the EFM are numerous and well bonded to each other. Not only do these hydration products increase the mechanical strength of EFM, but they also successfully solidify the hazardous components in MSWIBA and reduce their negative environmental effects. In addition, the use of MSWIBA instead of sand for mortar preparation reduces energy consumption and CO2 emissions, and it reduces the cost by more than 50 %. This indicates that MSWIBA may perform well in the future development of the civil infrastructures. As well as recycling waste resources, it makes a valuable contribution to the development of green and sustainable building materials.
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| 5. |
- Fan, Xu, et al.
(författare)
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New applications of municipal solid waste incineration bottom ash (MSWIBA) and calcined clay in construction: Preparation and use of an eco-friendly artificial aggregate
- 2023
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Ingår i: Construction and Building Materials. - 0950-0618. ; 387
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study is to prepare MSWIBA as eco-friendly artificial aggregates (EFAAs) by cold bond granulation technique using a low carbon limestone calcined clay cement (LC3). The water absorption rate of EFAAs is between 14.42 and 21.82%, and the maximum compressive strength can reach 2.5 MPa. Calcined clay particles can effectively adsorb heavy metal ions after absorbing water, and EFAAs can reduce the leaching value of toxic elements in MSWIBA by more than half on average. Compared to standard OPC cementitious materials, LC3 composites only need 50% of the energy and discharge 43% of the CO2, producing a more environmentally friendly artificial aggregate. In addition, the 28-day compressive strength of concrete was higher than 30 MPa on average after applying EFAAs to concrete. The good application capability shown by EFAAs, as well as their low energy consumption and low carbon environmental characteristics, promote the better application of MSWIBA in buildings.
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| 6. |
- Jin, Hesong, et al.
(författare)
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An experimental study on the influence of continuous ambient humidity conditions on relative humidity changes, chloride diffusion and microstructure in concrete
- 2022
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Ingår i: Journal of Building Engineering. - : Elsevier BV. - 2352-7102. ; 59
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Tidskriftsartikel (refereegranskat)abstract
- Most engineering structures are exposed to various harsh environments, such as temperature fluctuations and humidity cycles, simultaneously. Additionally, moisture transfer and corrosive ion transport in concrete are driven by humidity gradients. Therefore, studying Chloride transport in concrete under constant humidity conditions is a meaningful research project. In this work, a new experimental setup was designed, and the Chloride diffusion behavior of concrete under a continuous humidity environment and NaCl immersion was investigated. Meanwhile, to accurately evaluate the internal humidity of concrete, humidity sensors were applied to the concrete. Additionally, the impacts of the water-binder ratio (w/b) and ambient humidity on the humidity diffusion coefficient, free Chloride content and bound Chloride content in concrete were evaluated. The microstructure was characterized by scanning electron microscopy, X-ray diffraction and mercury intrusion porosimetry. The results show that the content of free Chloride increases with an increasing w/b ratio. The humidity diffusion coefficient of concrete during water absorption (continuous high humidity environment) is significantly higher than that during water loss (continuous dry environment). Furthermore, under the drying condition, the Chloride content and the humidity diffusion coefficient on the concrete surface gradually increased, while during the wetting procedure, the Chloride content inside the concrete increased, and the humidity diffusion coefficient gradually decreased. However, the bound Chloride content inside the concrete is not affected by the humidity level in the environment. In the wetting environment, the calcium hydroxide in the matrix is gradually consumed, and the Chloride diffuses to the matrix to form more Friedel's salt and calcium carbonate. Moreover, lowering the w/b ratio or increasing the ambient humidity can enhance the formation of more hydrated compounds (C–S–H gel), which can reduce the total porosity and can also improve the ability of concrete to resist Chloride diffusion. Overall, this study provides a better understanding of and insight into the design and maintenance of seaside RC infrastructures.
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| 7. |
- Jin, Hesong, et al.
(författare)
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Iodide and chloride ions diffusivity, pore characterization and microstructures of concrete incorporating ground granulated blast furnace slag
- 2022
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Ingår i: Journal of Materials Research and Technology. - : Elsevier BV. - 2238-7854 .- 2214-0697. ; 16, s. 302-321
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Tidskriftsartikel (refereegranskat)abstract
- Innovative approaches are under research to study the resistance of chloride ion penetration in concrete containing chloride ions, to minimize the impact of chloride ion penetration test errors in coastal reinforced concrete (RC), which is helpful to the design of coastal RC structures. In this study, the diffusion depth, free ion concentration and diffusion coefficient of chloride, iodide ions with different curing ages and GGBFS content were measured by the Rapid Chloride Migration Test (RCM) and Rapid Iodide Migration tests (RIM). The SEM-EDS and MIP were used to analyze the microstructures, pore size distribution and the hydrated products. The results show that the performance of GGBFS concrete against the diffusion of corrosive ions is affected by the curing age and the content of GGBFS. With the increase of GGBFS content, especially concrete with 60% GGBFS, the influence of chloride, iodide ion penetrating into concrete gradually becomes smaller. The long-age curing system is more conducive to the concrete resistance to the migration and diffusion of chloride, iodine ions. Compared with the ordinary concrete, the total porosity of concrete mixed with GGBFS is lower, the internal microstructures have fewer cracks and defects, the density is better, and the diffusion coefficient of chloride and iodide ions is also lower. In addition, using the concept of corrosive ion adjustment coefficient (conversion coefficient of diffusion between chloride ion and iodide ion) and applying the data regression analysis (DRA), it is found that there is a good quadratic parabolic function relationship between the GGBFS content and the ions adjustment coefficient.
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| 8. |
- Karlsson Wede, Oskar, et al.
(författare)
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Mechanical function of intermediate filaments in arteries of different size examined using desmin deficient mice.
- 2002
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Ingår i: Journal of Physiology. - : Wiley. - 1469-7793 .- 0022-3751. ; 540:Pt 3, s. 941-949
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Tidskriftsartikel (refereegranskat)abstract
- Protein composition and mechanical function of intermediate filaments were examined in arteries of different sizes using desmin deficient mice (Des-/-) and their wild-type controls (Des+/+). Using SDS-PAGE gels and Western blots we found a gradient in desmin expression in the arterial tree; the desmin content increased from the elastic artery aorta, via the muscular mesenteric artery to the resistance-sized mesenteric microarteries approximately 150 microm in diameter in Des+/+ mice. Mechanical experiments were performed on the aorta, the mesenteric artery and resistance-sized arteries using wire myographs. For aorta and mesenteric artery, no differences in passive or active circumference- stress relations were found between Des-/- and Des+/+ mice. In microarteries, both passive and active stress were lower in the Des-/- group. In conclusion, large elastic and muscular arteries contain a relatively low amount of desmin, and the desmin intermediate filaments do not seem to play a major role in the mechanical properties of these larger arterial vessels. In the microarteries, where expression of desmin is high, desmin plays a role in supporting both passive and active tension.
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| 9. |
- Li, Zhenlin, et al.
(författare)
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Research on the durability and Sustainability of an artificial lightweight aggregate concrete made from municipal solid waste incinerator bottom ash (MSWIBA)
- 2023
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Ingår i: Construction and Building Materials. - : Elsevier BV. - 0950-0618. ; 365
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Tidskriftsartikel (refereegranskat)abstract
- This study chooses to use three common cementing materials, Portland cement (OPC), ground granulated blast furnace slag (GGBFS) and fly ash (FA), as the binder for the production of three artificial lightweight coarse aggregates (ALCAs) through cold bonding with municipal solid waste incineration bottom ash (MSWIBA) in which MSWIBA accounts for 70% of the total content by volume. In this study, three ALCAs were used to replace 0%, 30%, 60%, and 100% of natural aggregates used in the production of concrete. Through capillary water absorption and rapid migration of chloride ions, the effect of the replacement amount of ALCAs on the durability of concrete was explored. Additionally, in accordance with the Material Sustainability Index (MSI), a statistical analysis of the CO2 emissions, energy consumption and cost of the concrete made of the three ALCAs was carried out. Studies have shown that ALCAs can improve the Interfacial Transition Zone (ITZ) and pore structure of concrete, thereby improving the ability of concrete to resist chloride ion penetration. In addition, the use of ALCAs can reduce the cost of concrete. Among the ALCAs used in this study, those which use GGBFS and FA as adhesives (without OPC) can improve the durability of concrete the most and reduce CO2 emissions.
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| 10. |
- Liu, Jun, et al.
(författare)
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Application potential analysis of biochar as a carbon capture material in cementitious composites: A review
- 2022
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Ingår i: Construction and Building Materials. - : Elsevier BV. - 0950-0618. ; 350
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Forskningsöversikt (refereegranskat)abstract
- In recent years, emissions of carbon dioxide in the atmosphere have been increasing, leading to increasingly severe global warming. In the construction industry, the increase in cement production is one of the main sources of CO2 emissions. Cementitious composites can sequester CO2 in calcium carbonate precipitates through carbonation reactions, but their carbon sequestration efficiency is very low due to the slow diffusion rate of CO2 in the cement matrix. To reduce the net CO2 emissions during concrete production, a feasible option is to enhance its carbon capture performance through accelerated carbonation curing (ACC) and CO2 capture and storage (CCS) technologies. Biochar has a strong adsorption capacity for CO2, its production process is green and low-carbon, and its production cost is low, which has high economic benefits. Many studies have applied biochar as cementitious composites in the construction industry to improve the mechanical properties, durability and functionality of cementitious composites. Additionally, biochar is a potential carbon capture material that can effectively improve the carbon sequestration performance of cementitious composites. In this review, the latest research progress of biochar in cementitious composites in recent years is reviewed, and the mechanical properties, durability and carbon sequestration performance of biochar-cementitious composites were analyzed. Additionally, the mechanism of the synergistic effect of biochar and the carbonization reaction in concrete and the effect on the carbon capture ability of cementitious composites were also investigated.
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