| 1. |
- Huang, Hongyun, et al.
(författare)
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Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)
- 2018
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Ingår i: Cell Transplantation. - : SAGE Publications. - 0963-6897 .- 1555-3892. ; 27:2, s. 310-324
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Forskningsöversikt (refereegranskat)abstract
- Cell therapy has been shown to be a key clinical therapeutic option for central nervous system diseases or damage. Standardization of clinical cell therapy procedures is an important task for professional associations devoted to cell therapy. The Chinese Branch of the International Association of Neurorestoratology (IANR) completed the first set of guidelines governing the clinical application of neurorestoration in 2011. The IANR and the Chinese Association of Neurorestoratology (CANR) collaborated to propose the current version "Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)". The IANR council board members and CANR committee members approved this proposal on September 1, 2016, and recommend it to clinical practitioners of cellular therapy. These guidelines include items of cell type nomenclature, cell quality control, minimal suggested cell doses, patient-informed consent, indications for undergoing cell therapy, contraindications for undergoing cell therapy, documentation of procedure and therapy, safety evaluation, efficacy evaluation, policy of repeated treatments, do not charge patients for unproven therapies, basic principles of cell therapy, and publishing responsibility.
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| 2. |
- Li, Luhan, et al.
(författare)
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Tailoring charge reconfiguration in dodecahedral Co2P@carbon nanohybrids by triple-doping engineering for promoted reversible oxygen catalysis
- 2022
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Ingår i: Journal of Materials Chemistry A. - : Royal Society of Chemistry. - 2050-7488 .- 2050-7496. ; 10:40, s. 21659-21671
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Tidskriftsartikel (refereegranskat)abstract
- Simultaneously tuning the electronic structure of active sites and the microenvironment of the carbon matrix in metal phosphide/carbon nanohybrids is the most effective way to design and develop bi-functional electrocatalysts for electrochemically related energy storage devices. Inspired by this, a robust and advanced N/P co-doped carbon-based dodecahedron catalyst with confined Fe-doped Co2P particles was successfully prepared through a multi-doping engineering strategy. Phytic acid molecules, which were used in the synthesis of the catalyst, not only contribute to the formation of the porous structure, but also act as a phosphorus source to form the corresponding metal phosphide and the P dopant in the carbon matrix. Thanks to the unique composition and structure-dependent merits, the microenvironment of the electrocatalyst was significantly modulated, thus promoting the advantageous local charge rearrangement and smooth mass/charge transfer processes during the oxygen-related electrocatalytic reactions. As a result, the resultant catalyst exhibited significantly enhanced reversible oxygen activity, as evidenced by an ultra-small potential gap of 0.655 V (half-wave potential of 0.895 V for the oxygen reduction reaction; η10 of 320 mV for the oxygen evolution reaction), a remarkable specific capacity of 762 mA h gZn−1, and high voltaic efficiency, exceeding most previous reports. This study provides a new synthetic approach for fabricating highly efficient bi-functional oxygen catalysts and can be handily extended to the synthesis of other heterogeneous electrocatalysts for sustainable energy storage.
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| 3. |
- Li, Shuai, et al.
(författare)
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Lanthanum gallate and ceria composite as electrolyte for solid oxide fuel cells
- 2010
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Ingår i: Journal of Alloys and Compounds. - : Elsevier BV. - 0925-8388 .- 1873-4669. ; 492:1-2, s. 392-395
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Tidskriftsartikel (refereegranskat)abstract
- The composite of doped lanthanum gallate (La(0.9)Sr(0.1)Ga(0.8)Mg(0.2)O(2.85), LSGM) and doped ceria (Ce(0.8)Sm(0.2)O(1.9), CSO) was investigated as an electrolyte for solid oxide fuel cell (SOFC). The LSGM-CSO composite was examined by X-ray diffraction (XRD) and impedance spectroscopy. It was found that the sintered LSGM-CSO composite contains mainly fluorite CeO(2) phase and a minority impurity phase, Sm(3)Ga(5)O(12). The LSGM-CSO composite electrolyte shows a small grain boundary response in the impedance spectroscopy as compared to LSGM and CSO pellets. The composite electrolyte exhibits the highest conductivity in the temperature range of 250-600 degrees C, compared to LSGM and CSO. The LSGM-CSO composite can be expected to be an attractive intermediate temperature electrolyte material for solid oxide fuel cells.
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| 4. |
- Zhou, Yin, et al.
(författare)
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Inflammation and Apoptosis: Dual Mediator Role for Toll-like Receptor 4 in the Development of Necrotizing Enterocolitis
- 2017
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Ingår i: Inflammatory Bowel Diseases. - : LIPPINCOTT WILLIAMS & WILKINS. - 1078-0998 .- 1536-4844. ; 23:1, s. 44-56
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Tidskriftsartikel (refereegranskat)abstract
- Background: Necrotizing enterocolitis (NEC) is the leading cause of neonatal gastrointestinal mortality; effective interventions are lacking with limited understanding of the pathogenesis of NEC. The importance of Toll-like receptor 4 (TLR4) signaling in NEC is well documented; however, the potential mechanisms that regulate enterocyte inflammation and apoptosis remain unclear. The aim of this study was to characterize the role of TLR4-mediated inflammation and apoptosis in the development of NEC and to determine the major apoptotic pathways and regulators in the process. Methods: TLR4-deficient C57BL/10ScNJ mice and lentivirus-mediated stable TLR4-silent cell line (IEC-6) were used. NEC was induced by formula gavage, cold, hypoxia, combined with lipopolysaccharide in vivo or lipopolysaccharide stimulation in vitro. Enterocyte apoptosis was evaluated by TUNEL or Annexin analysis. The expression of TLR4, caspase3, caspase8, caspase9, Bip, Bax, Bcl-2, and RIP was detected by Western blot and immunofluorescence. Inflammatory factors such as tumor necrosis factor-a and interleukin-2 were examined by Luminex. Results: Defect of TLR4 led to suppressed enterocytes apoptosis both in vitro and in vivo; the expression of caspase3, caspase8, Bip, and Bax was decreased; and caspase9 and Bcl-2 were increased. NEC severity was attenuated in TLR4-deficient mice compared with wild-type counterparts, and enterocytes apoptosis was correlated with NEC severity. RIP and cytokine level of tumor necrosis factor-a and interleukin-2 were also decreased. Conclusions: TLR4-induced inflammation and apoptosis play a critical role in the pathogenesis of NEC. TLR4 inhibition, combined with extrinsic (caspase8) and/or endoplasmic reticulum stress (Bip) apoptosis signaling blockade could serve as a potential effective treating strategy for NEC.
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| 5. |
- He, Kun, et al.
(författare)
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Experimental study on flame characteristics of double fires in a naturally ventilated tunnel : Flame merging, flame tilt angle and flame height
- 2021
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Ingår i: Tunnelling and Underground Space Technology. - : Elsevier Ltd. - 0886-7798 .- 1878-4364. ; 114
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Tidskriftsartikel (refereegranskat)abstract
- A series of fire tests was carried out to investigate the diffusion flame characteristics of double fires generated from separated burners in a naturally ventilated tunnel, considering different heat release rates and fire separation distances. The results show that the flame tilt angle, as well as the horizontal projected flame length, first increases with fire separation distance and then remains constant, but the vertical flame length first decreases and then remains constant, which is different from two fires in free spaces where flames do not tilt when the separation distance is relatively long. This difference is caused by the non-dimensional fire induced air flow velocity in the tunnel, which is mainly related to the tunnel cross-section dimensions and burner radius. Three regions can be identified, i.e. flame vertical merging, plume vertical merging and non-merging with flame tilted. The critical flame merging separation distance, estimated by the flame merging probability, is greater than that of two fires in an open environment due to the fire-induced air flows. The merging flame height is lower than that of a single fire with a same heat release rate. A correlation was proposed to estimate flame height of two fires in a tunnel by the modified non-dimensional heat release rate using an air entrainment perimeter as the characteristic length. This work enhances the understanding of diffusion flame behaviors of double fires in naturally ventilated tunnels.
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| 6. |
- Kese, Kwadwo, et al.
(författare)
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Influence of residual stress on elastic modulus and hardness of soda-lime glass measured by nanoindentation
- 2004
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Ingår i: Journal of Materials Research. - : Springer Science and Business Media LLC. - 0884-2914 .- 2044-5326. ; 19:10, s. 3109-3119
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Tidskriftsartikel (refereegranskat)abstract
- The influence of stress on the elastic modulus E and hardness H in soda-lime glass was studied in the Vickers residual stress field by nanoindentation. The Oliver-Pharr method of analysis first gave higher values of E and H, but after correcting for the pileup contact areas around the nanoindents, results consistent with literature values were obtained at regions in the stress field where the stresses were either low or close to zero. Determination of the pileup contact areas was made possible by the use of the atomic force microscope, which has facility for generating cross-section images of the indents. The elastic modulus was found to decrease with stress, which is explained with reference to the influence of applied stresses on the Si-O-Si bond angle. The hardness on the other hand did not depend on the stresses except in the region very close to the edge of the Vickers indent where the stresses are high.
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| 7. |
- Li, Zhicheng, et al.
(författare)
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Direct observation of electron-beam-induced nucleation and growth in amorphous GaAs
- 2004
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Ingår i: Materials Science in Semiconductor Processing. - : Elsevier BV. - 1369-8001 .- 1873-4081. ; 7:1-2, s. 19-25
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Tidskriftsartikel (refereegranskat)abstract
- In situ observation of the nucleation and growth stimulated by an electron beam in amorphous GaAs was performed using a high-resolution electron microscopy. The results showed that the crystallization was closely related to the current density of the electron beam. Crystallization could not take place when the current density was 50 pA/cm(2), nanocrystals with the random orientation formed under the 74 pA/cm(2) electron beam, large grains and twining structure formed during the crystallization induced by the 93 pA/cm(2) electron beam. Ionization process and electron-beam heating were suggested to be the possible mechanisms for the irradiation-induced crystallization.
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| 8. |
- Li, Zhicheng, et al.
(författare)
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Growth and morphology of beta phase in an Mg-Y-Nd alloy
- 2004
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Ingår i: Materials letters (General ed.). - : Elsevier BV. - 0167-577X .- 1873-4979. ; 58:24, s. 3021-3024
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Tidskriftsartikel (refereegranskat)abstract
- The phase precipitated in an Mg-Y-Nd alloy during ageing was studied using electron microscopy. Observations were performed along the orientations paralleling to [0001] and [11 (2) over bar0] zone axes of the matrix. The results showed that the platelike p phase has three variants growing along three <1120> directions of the matrix, the beta phase grew faster along <0001>(alpha) and <1120>(alpha) directions than along the third direction (<1 (1) over bar 00>). The morphology of the beta phases was illustrated according to the analysis of the directional misfit between the beta phase and the matrix.
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| 9. |
- Li, Zhicheng, et al.
(författare)
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Influence of AST additives on the stability of PTCR characteristics and microstructure in ferroelectric ceramics
- 2004
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Ingår i: Journal of materials science. Materials in electronics. - 0957-4522 .- 1573-482X. ; 15:8, s. 561-567
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Tidskriftsartikel (refereegranskat)abstract
- (Ba0.69Pb0.31)TiO3 ceramics were prepared using Al2O3, SiO2, additives and excess of TiO2 (AST). The characteristics of positive temperature coefficient of resistivity (PTCR) was studied and the corresponding microstructures were investigated using atomic force microscopy and scanning electron microscopy. The results showed that the PTCR effect was related to the AST additives. The maximum value of resistivity in the ceramics with lower content of or without Al2O3 and SiO2 additives was much lower than in those with AST additives. Ceramics with low AST content, which were heated by electric field to a temperature much higher than their Curie temperature, lost the PTCR effect after the electric field stimulation. The microstructure observations revealed that re-crystallization took place in the ceramics with lower content of or without AST additives resulting in the loss of the PTCR effect.
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| 10. |
- Li, Zhicheng, et al.
(författare)
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Microstructure and PTCR effect of La-doped BaPbO3 ceramics
- 2004
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Ingår i: Journal of materials science. Materials in electronics. - 0957-4522 .- 1573-482X. ; 15:3, s. 183-186
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Tidskriftsartikel (refereegranskat)abstract
- La-doped BaPbO3 ceramics were prepared by using BaCO3 and PbO. Electrical properties and microstructure of the ceramics were studied. The results show a thin surface layer with a very low resistivity, and the interior of the ceramics with the characteristics of positive temperature coefficient of resistivity (PTCR). The PTCR behavior was related to the La content. The investigation by scanning electron microscopy and transmission electron microscopy revealed that the low resistivity of the surface layer was due to formation of a nano-size BaPbO3 phase with metallic properties.
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