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- Bergman, Jan, et al.
(författare)
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Reactions of 1,2-bis(1H-indol-2-yl)ethane : Formation of indolo[2,3-c]carbazole and cyclohept[1,2-b : 5,4-b ']bisindole derivatives
- 2000
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Ingår i: Tetrahedron. - 0040-4020 .- 1464-5416. ; 56:13, s. 1911-1916
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Tidskriftsartikel (refereegranskat)abstract
- 1,2-Bis(1H-indol-2-yl)ethane (9) has been prepared and converted into indolo[2,3-c]carbazole (8) using palladium acetate in refluxing acetic acid. Reaction of 9 with CoF3 in hot TFA led to isolation of cyclohept[1,2-b:5,4-b']bisindole derivatives 11 and 12, which could be elaborated into further derivatives. Treatment of 9 with orthoesters, aldehydes and ketones under acidic conditions afforded additional bisindoles containing a seven-membered ring.
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- Bergman, Jan, et al.
(författare)
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Synthesis of indolocarbazole quinones; potent aryl hydrocarbon receptor ligands
- 2002
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Ingår i: Tetrahedron. - 0040-4020 .- 1464-5416. ; 58:7, s. 1443-1452
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Tidskriftsartikel (refereegranskat)abstract
- Syntheses of indolo[2,3-b]carbazole-6,12-dione and the isomeric indolo[3,2-b]carbazole-6,12-dione, an extremely efficient inducer of the aryl hydrocarbon (Ah) receptor are described. Initial oxidation of the parent indolo[3,2-b]carbazole followed by several different ring-closing strategies produced the latter compound. Entries into syntheses of unsymmetrical 6,12-disubstituted indolo[2,3-b]carbazoles are also described.
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