| 1. |
|
|
| 2. |
- Lidström, Anders, 1953-, et al.
(författare)
-
Konsolidering och breddning: 2000-2015
- 2015
-
Ingår i: 50 år med Statsvetenskap i Umeå. - Umeå : Statsvetenskapliga institutionen, Umeå universitet. - 9789176012956 ; , s. 53-83
-
Bokkapitel (populärvet., debatt m.m.)
|
|
| 3. |
- Weghuber, D., et al.
(författare)
-
A 6-month randomized, double-blind, placebo-controlled trial of weekly exenatide in adolescents with obesity
- 2020
-
Ingår i: Pediatric Obesity. - 2047-6302 .- 2047-6310. ; 15:7
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Pharmacological treatment options for adolescents with obesity are very limited. Glucagon-like-peptide-1 (GLP-1) receptor agonist could be a treatment option for adolescent obesity.OBJECTIVE: To investigate the effect of exenatide extended release on body mass index (BMI)-SDS as primary outcome, and glucose metabolism, cardiometabolic risk factors, liver steatosis, and other BMI metrics as secondary outcomes, and its safety and tolerability in adolescents with obesity.METHODS: Six-month, randomized, double-blinded, parallel, placebo-controlled clinical trial in patients (n = 44, 10-18 years, females n = 22) with BMI-SDS > 2.0 or age-adapted-BMI > 30 kg/m2 according to WHO were included. Patients received lifestyle intervention and were randomized to exenatide extended release 2 mg (n = 22) or placebo (n = 22) subcutaneous injections given once weekly. Oral glucose tolerance tests (OGTT) were conducted at the beginning and end of the intervention.RESULTS: Exenatide reduced (P < .05) BMI-SDS (-0.09; -0.18, 0.00), % BMI 95th percentile (-2.9%; -5.4, -0.3), weight (-3 kg; -5.8, -0.1), waist circumference (-3.2 cm; -5.8, -0.7), subcutaneous adipose tissue (-552 cm3 ; -989, -114), 2-hour-glucose during OGTT (-15.3 mg/dL; -27.5, -3.1), total cholesterol (11.6 mg/dL; -21.7, -1.5), and BMI (-0.83 kg/m2 ; -1.68, 0.01) without significant change in liver fat content (-1.36; -3.12, 0.4; P = .06) in comparison to placebo. Safety and tolerability profiles were comparable to placebo with the exception of mild adverse events being more frequent in exenatide-treated patients.CONCLUSIONS: Treatment of adolescents with severe obesity with extended-release exenatide is generally well tolerated and leads to a modest reduction in BMI metrics and improvement in glucose tolerance and cholesterol. The study indicates that the treatment provides additional beneficial effects beyond BMI reduction for the patient group.
|
|
| 4. |
-
50 år med Statsvetenskap i Umeå
- 2015
-
Samlingsverk (redaktörskap) (populärvet., debatt m.m.)abstract
- Statsvetenskapliga institutionen vid Umeå universitet etablerades samtidigt som Umeå universitet invigdes 1965. Denna bok berättar historien om institutionens första femtio år. Den ger inblickar i viktiga händelser, avgörande beslut, genomgående tendenser och tongivande förändringar. Det är en historia med både glädjeämnen och besvikelser, framgångar och motgångar.Att institutionen överlevt, expanderat och delvis kunnat förnya sig vittnar dock om att den i grunden utgör en livskraftig och dynamisk akademisk miljö med engagerade och kompetenta medarbetare.
|
|
| 5. |
|
|
| 6. |
- Baldersheim, Harald, et al.
(författare)
-
The anatomy and drivers of local autonomy in a European perspective
- 2017
-
Ingår i: Starke Kommunen - wirksame Verwaltung. - Wiesbaden : Springer. - 9783658171346 - 9783658171353 ; , s. 85-100
-
Bokkapitel (refereegranskat)abstract
- Making democracy work is a continuous struggle (Putnam 1993). This also goes for local democracy (Wollmann 1999), including the maintenance of the autonomy of local government, which is the basis for local democracy. The autonomy of local government varies across countries but there is little understanding of why systems of local government develop in such different ways. The purpose of this article is to contribute to such an understanding. The variation in local autonomy as well as the lack of explanations for it is remarkable since local autonomy is a cherished ideal for local government in liberal-democratic societies. Indeed, local autonomy is one of the constituent features of local government, perhaps the most fundamental feature. Local government is of course established by the state and serves the state both literally and in a wider sense. Yet, without some measure of autonomy from the state local democracy is meaningless — there will be no policy space for decision-makers and no choice for citizens. Arguably, local autonomy is also a driver of efficiency in local government affairs through the adaptive opportunities to local circumstances made possible by autonomous decision-makers accountable to local citizens as tax payers and consumers.
|
|
| 7. |
- Copus, Colin, et al.
(författare)
-
Have mayors will travel : trends and developments in the direct election of the mayor : a five-nation study
- 2016
-
Ingår i: Local public sector reforms in times of crisis. - London : Palgrave Macmillan. - 9781137525475 ; , s. 301-315
-
Bokkapitel (refereegranskat)abstract
- Whether citizens should directly elect the mayor or whether only councilors should be able to indirectly choose the local political governing body to the exclusion of the public from the process is one of the most controversial debates around the reform of local government—at least for policy makers and councilors. Debates about direct or indirect election of local political leaders focus on different interpretations of political concepts such as: the legitimacy to act, visibility and profile of local leaders, transparency of political decision-making processes, accountability, and the role of the citizen in local representative democracy. The chapter takes five European countries selected because of their different political traditions and structures, to assess the nature of the policy debate about the selection of the local political leader. It does this to assess how far path-dependent responses to reform have influenced political change or whether crisis moments provide opportunities for new considerations about the reform of local politics to emerge.
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
