| 1. |
- Adoue, Veronique, et al.
(författare)
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Allelic expression mapping across cellular lineages to establish impact of non-coding SNPs
- 2014
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Ingår i: Molecular Systems Biology. - : EMBO. - 1744-4292 .- 1744-4292. ; 10:10, s. 754-
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Tidskriftsartikel (refereegranskat)abstract
- Most complex disease-associated genetic variants are located in non-coding regions and are therefore thought to be regulatory in nature. Association mapping of differential allelic expression (AE) is a powerful method to identify SNPs with direct cis-regulatory impact (cis-rSNPs). We used AE mapping to identify cis-rSNPs regulating gene expression in 55 and 63 HapMap lymphoblastoid cell lines from a Caucasian and an African population, respectively, 70 fibroblast cell lines, and 188 purified monocyte samples and found 40-60% of these cis-rSNPs to be shared across cell types. We uncover a new class of cis-rSNPs, which disrupt footprint-derived de novo motifs that are predominantly bound by repressive factors and are implicated in disease susceptibility through overlaps with GWAS SNPs. Finally, we provide the proof-of-principle for a new approach for genome-wide functional validation of transcription factor-SNP interactions. By perturbing NFκB action in lymphoblasts, we identified 489 cis-regulated transcripts with altered AE after NFκB perturbation. Altogether, we perform a comprehensive analysis of cis-variation in four cell populations and provide new tools for the identification of functional variants associated to complex diseases.
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| 2. |
- Akama, Yoko, et al.
(författare)
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Expanding Participation to Design with More-Than-Human Concerns
- 2020
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Ingår i: PDC '20: Proceedings of the 16th Participatory Design Conference 2020 - Participation(s) Otherwise - Volume 1. - New York, NY, USA : ACM Digital Library. - 9781450377003
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Konferensbidrag (refereegranskat)abstract
- Participatory Design's focus on people comes from a social democratic vision. However, as climate and existential crises press us to consider wellbeing beyond humans alone, we ask what a pluriversal design agenda might include and what could be articulated as ‘participatory’? Necessarily, this inquiry has limits, as participation usually implies human voice, rights, representation and structures of decision-making. This paper commits to these concerns while asking ethical, political and onto-epistemological questions regarding how worlds and futures are shaped when more-than-human entities – plants, animals, rocks, rivers and spirits – participate in our becoming? We offer a meeting of feminist techno-science with practices and philosophies from Japan and beyond to offer thought experiments in engaging with difference and plurality. And we give several examples of practice situated at ontological boundaries to offer some novel thoughts on ‘participation otherwise’, always-participating-with-many and the futures this could usher in.
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| 3. |
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| 4. |
- Bardzell, Jeffrey, et al.
(författare)
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Wanting To Live Here : Design After Anthropocentric Functionalism
- 2021
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Ingår i: CHI '21. - New York, NY, USA : ACM Digital Library. - 9781450380966
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Konferensbidrag (refereegranskat)abstract
- Design research has recently turned to theoretical perspectives, including care ethics and posthumanism, to counter the industrial processes that have led to climate crisis. As design theorists and ethnographers of interaction, we researched experimental eco-farming in a community that shared many of these theoretical and ideological commitments. Our goal was not to offer an account of use and provide design implications in support of it. Instead, we chose to identify concrete practices and artifacts that embody the sorts of industrial transformations that we are seeking-even if they are manifest in an imperfect or partial form. We encountered practices focused on community building, local resilience to climate disruptions, experiments in eco-farming, economic survival, and attracting the next generation. One interlocutor translated these concerns into a simple binary, asking, "do we want to live here?" This paper contributes to a design research agenda that might (eventually) provide an afirmative answer.
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| 5. |
- Casaletto, K. B., et al.
(författare)
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Tripartite Relationship Among Synaptic, Amyloid, and Tau Proteins An In Vivo and Postmortem Study
- 2021
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Ingår i: Neurology. - : Ovid Technologies (Wolters Kluwer Health). - 0028-3878 .- 1526-632X. ; 97:3
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Tidskriftsartikel (refereegranskat)abstract
- Objective To test the hypothesis that fundamental relationships along the amyloid, tau, and neurodegeneration (A/T/N) cascade depend on synaptic integrity in older adults in vivo and postmortem. Methods The 2 independent observational, cross-sectional cohorts included (1) in vivo community-dwelling, clinically normal adults from the University of California, San Francisco Memory and Aging Center who completed lumbar puncture and MRI (exclusion criteria, Clinical Dementia Rating score >0) and (2) postmortem decedents from the Rush Memory and Aging Project (exclusion criteria, inability to sign informed consent). In vivo measures included CSF synaptic proteins (synaptotagmin-1, synaptosome associated protein-25, neurogranin, and growth associated protein-43), beta-amyloid (A beta(42/40)), tau phosphorylated at amino acid 181 (ptau(181)), and MRI gray matter volume (GMV). Postmortem measures captured brain tissue levels of presynaptic proteins (complexin-I, complexin-II, vesicle associated membrane protein (VAMP), and SNARE complex) and neuritic plaque and neurofibrillary tangle (NFT) counts. Regression models tested statistical moderation of synaptic protein levels along the A/T/N cascade (synaptic proteins x amyloid on tau, and synaptic proteins x tau on GMV). Results Sixty-eight in vivo older adults (age 71 years, 43% female) and 633 decedents (age 90 years, 68% female, 34% clinically normal) were included. Each in vivo CSF synaptic protein moderated the relationship between A beta(42/40) and ptau(181) (-0.23 < beta < -0.12, p < 0.05) and the relationship between ptau(181) and GMV (-0.49
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| 6. |
- Choi, Jaz Hee-jeong, et al.
(författare)
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'The co-': feminisms, power and research cultures
- 2020
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Ingår i: interactions. - : Association for Computing Machinery (ACM). - 1072-5520 .- 1558-3449. ; 27:6, s. 26-28
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- This article is polyvocal and tentative. We, Jaz and Ann, are exploring the beliefs that motivate our work, in this first of Jaz’s columns. For both of us, collaborative working is a method but also an end point—a goal that recognizes the interdependent nature of all life and looks to support it. Here we discuss the “co-” in co-design through a dialogical reflection on feminism and process.
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| 7. |
- Dolejšová, Markéta, et al.
(författare)
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Designing for transformative futures : Creative practice, social change and climate emergency
- 2021
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Ingår i: C&C '21. - New York, NY, USA : Association for Computing Machinery. - 9781450383769
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Konferensbidrag (refereegranskat)abstract
- We discuss three cases of transformative creative practice that aim to address large-scale societal issues related to the climate emergency by taking a series of interconnected, small-scale actions. Drawing on our first-hand perspectives, we reflect on how the cases address such issues by proliferating across different social contexts and supporting creative engagements of diverse stakeholders. We offer this empirical reflection at a time of rapid social and ecological change that has affected all life on the planet. Eco-social challenges and structural inequalities caused by shifts in global economic, political and technological power require new approaches and transformative actions to stabilize and restore ecosystems on which life depends. Our research shows that creative practice in art and design has a critical role to play in these processes of transformation. By discussing the opportunities and challenges encountered by our three cases within their transformative efforts and analyzing how they proliferate across diverse scales, we aim to expand the emerging scholarship on the transformative potential of creative practice.
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| 8. |
- Dolešová, Markéta, et al.
(författare)
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Designing with More-than-Human Food Practices for Climate-Resilience
- 2020
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Ingår i: DIS 2020 Companion. - New York, NY, USA : Association for Computing Machinery (ACM). - 9781450379878 ; , s. 381-384
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Konferensbidrag (refereegranskat)abstract
- Climate change is an increasingly urgent, complex problem, with consequences threatening human and non-human lives across the globe. Legislative and citizen-driven responses are valuable but insufficient, and their practical feasibility is unclear. Emerging design research suggests embracing imaginative, creative approaches to support engagement with climate-change issues and inspire collective reflection. This workshop investigates how such approaches can be applied through co-creative design experimentation in the context of human-food practices, which are now recognized as a key driver of climate change. We will reflect on existing climate-change mitigation proposals by imagining their plausible implementations as climate-resilient food practices, emphasizing more-than-human concerns. The workshop is organized as part of a two-day program titled Experimental Food Design for Sustainable Futures inviting diverse participants interested in contributing toward sustainable socio-ecological transformations.
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| 9. |
- Erickson, Ingrid, et al.
(författare)
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Envisioning Futures of Practice-Centered Computing
- 2019
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Ingår i: Proceedings of the 17th European Conference on Computer-Supported Cooperative Work - Demos and Posters. - : European Society for Socially Embedded Technologies (EUSSET).
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In this panel, we will engage with the conference's membership and friends to consider directions for the possible futures of practice-centered computing. This panel is not targeting or aiming to result in a single, agreed "universal” vision, nor to ask for a shared vision among the panelists and the audience. Rather, we offer several and diverse vision statements by distinguished and innovative ECSCW scholars, being experts in their specific domain or context of research. These statements will be necessarily incomplete until the ECSCW membership has joined the discussion, offering their own, additional visions of the futures of the field. With this, the panel aims to engage in a discussion that foresees exciting future research directions for the field of ECSCW but likewise also unveils potential hurdles the community might face.
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| 10. |
- Fazey, Ioan, et al.
(författare)
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Transforming knowledge systems for life on Earth : Visions of future systems and how to get there
- 2020
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Ingår i: Energy Research & Social Science. - : Elsevier. - 2214-6296 .- 2214-6326. ; 70
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Tidskriftsartikel (refereegranskat)abstract
- Formalised knowledge systems, including universities and research institutes, are important for contemporary societies. They are, however, also arguably failing humanity when their impact is measured against the level of progress being made in stimulating the societal changes needed to address challenges like climate change. In this research we used a novel futures-oriented and participatory approach that asked what future envisioned knowledge systems might need to look like and how we might get there. Findings suggest that envisioned future systems will need to be much more collaborative, open, diverse, egalitarian, and able to work with values and systemic issues. They will also need to go beyond producing knowledge about our world to generating wisdom about how to act within it. To get to envisioned systems we will need to rapidly scale methodological innovations, connect innovators, and creatively accelerate learning about working with intractable challenges. We will also need to create new funding schemes, a global knowledge commons, and challenge deeply held assumptions. To genuinely be a creative force in supporting longevity of human and non-human life on our planet, the shift in knowledge systems will probably need to be at the scale of the enlightenment and speed of the scientific and technological revolution accompanying the second World War. This will require bold and strategic action from governments, scientists, civic society and sustained transformational intent.
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